Electrochemical chiral sensor for levofloxacin detection base on Cu/Fe-BTC amplification

The key to developing sensors for chiral drug determination is to exclude interference from enantiomers. In this study, metal–organic frameworks (MOFs) and molecularly imprinted polymer (MIP) were introduced to prepare a chiral sensor for levofloxacin detection. The MIP was electropolymerised on the surface of the Cu/Fe-benzene-1,3,5-tricarboxylate MOF (Cu/Fe-BTC)-modified Au electrode using levofloxacin as a template molecule. After eluting the levofloxacin, a chiral sensor with recognition sites for levofloxacin was obtained. With this site as a switch, a novel method for detecting levofloxacin was established. Because of the enhanced recognition effect, the sensor can effectively exclude the enantiomeric interference of d-ofloxacin. Moreover, Cu/Fe-BTC can effectively amplify the current response signal and improve the sensitivity of the sensor. The linear range of the sensor was 5 to 4000 × 10 −11  mol L −1 , and the detection limit was 2.07 × 10 −11  mol L −1 . When applied to detecting levofloxacin in actual samples, the sensor showed a 92.7–109.8% recovery. Graphical