Monodisperse copper selenide nanoparticles for ultrasensitive and selective non-enzymatic glucose biosensor

The design of sensitive and fast-response of catalysts are very important for non-enzymatic glucose biosensors. In this work, monodisperse copper selenide (Cu 2-x Se) nanoparticles (NPs) are prepared by thermal decomposition of copper acetylacetonate (Cu(acac) 2 ) in the solution of oleylamine, then selenide at different temperatures with reduce graphene oxide (RGO) as support. These Cu 2-x Se NPs are active catalysts as ultrahigh sensitive non-enzymatic glucose biosensor, which exhibits sensitivity of 536 μA mM −1  cm −2 , a wide linear range up to 3.375 mM and a low detection limit of 0.05 mM (S/N = 3). Based on good selectivity, sensitivity and the ability of anti-interference, the Cu 2-x Se NPs will be the promising sensor for enzyme-free monitoring of glucose.