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Silver-mediated fluorination of alkyl iodides with TMSCF3 as the fluorinating agent

Journal 2017 · IF 4.955 · 4(10): 1958-1961 · 发表于 2017 年 6 月 27 日
作者: Liyan Wang,Xiaohuan Jiang,Pingping Tang
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摘要

The first example of a silver-mediated fluorination of alkyl iodides with the Ruppert–Prakash reagent (TMSCF3) as a fluorinating agent has been reported. This reaction is compatible with a variety of functional groups and proceeds under mild reaction conditions. Moreover, we demonstrate that the large surface area of CaF2 dramatically increased the reaction yield.