Fluorinated sodium carboxymethyl cellulose nanoparticles as carrier for improving adhesion and sustaining release of AVM

The loss and overuse of avermectin (AVM) on protecting plants pose a threat to ecosystems. To increase the efficacy of AVM, fluorinated sodium carboxymethyl cellulose (CMC-g-PHFBA) was synthesized by inducing poly 2, 2, 3, 4, 4, 4-hexafluorobutyl methacrylate (HFBA), and AVM was then enveloped in CMC-g-PHFBA (AVM@CMC-g-PHFBA) via hydrophobic interaction. According to the results, the samples exhibited desirable angle contact (min = 58.18°), retention rate (max = 60%, after water washing) and LHC (15.5 mg/cm2) on cucumber leaves. AVM@CMC-g-PHFBA also showed good storage stability with obvious Tyndall effect (size <240 nm and charge <–21 mV) for 11 days, with higher anti-UV property. The loaded AVM nanoparticles can release drugs for 95 h, which can be fitted to a zero-order model under different pH conditions for achieving a prolonged pharmacological action. Moreover, the samples have retained insecticidal activity. Collectively, CMC-g-PHFBA nanoparticles are promising delivery systems of AVM with the adhesive and sustained-release property.