Regioselective Coupling Reactions of Coumarins with Aldehydes or Di-tert-butyl Peroxide (DTBP) through a C(sp2)–H Functionalization Process

Coumarin derivatives are highly valuable compounds in drug discovery. Herein, we have developed two new coupling reactions that involve coumarins and either aldehydes or di- tert -butyl peroxide (DTBP) in the presence of inexpensive copper or iron catalysts. Both of these reactions proceed through a C(sp 2 )–H functionalization process to regioselectivity generate keto- or methyl-substituted coumarin derivatives in moderate to good yields These coupling reactions will enrich current coumarin chemistry. Graphical Two coupling reactions that regioselectively yield either keto- or methyl-substituted coumarin derivatives by proceeding through a C(sp 2 )–H functionalization process were successfully developed. The coupling of coumarins with either aldehydes or di- tert -butyl peroxide (DTBP) generated the corresponding products in moderate to good yields.