Heparin Modified Temperature-Sensitive Hydrogels and Biocompatibility Research

Chitosan/Heparin (CS/Hep) modified temperature sensitive hydrogels of γ-PGA were prepared by layer-by-layer self-assembly process. The chemical structure of the hydrogels and the surface elements were characterized by FT-IR spectrograph, XPS and TBO staining. The biocompatibility of the CS/Hep modified ploy (γ-PGA-co-NIPAAm) hydrogels were analyzed by the experiments of cell adhesion, cell proliferation and low-temperature induced cell detachment. A temperature-sensitive hydrogels carrier that could specific binding to growth factor was prepared in this research.