Hyaluronic Acid-Templated Ag Nanoparticles/Graphene Oxide Composites for Synergistic Therapy of Bacteria Infection

Developing methods of decreasing the harm to cell and increasing the antibacterial efficiency is becoming a potential topic of medical treatments. We demonstrated a hyaluronidase-triggered photothermal platform for killing bacteria based on silver nanoparticles (AgNPs) and graphene oxide (GO). The property of the hyaluronidase (HAase)-triggered release provided excellent antibacterial activity against Staphylococcus aureus. Upon illumination of NIR light, the GO-based nanomaterials locally raised the temperature, resulting in high mortality of bacteria. The HAase-triggered AgNPs releasing approach for antibacterial allows AgNPs to be protected by hyaluronic acid (HA) template without affecting mammalian cells. The nanocomposites provided antibacterial activity against S. aureus while showing low toxicity to mammal cells. In addition, the GO–HA–AgNPs are prepared for in vivo experiments and show excellent antibacterial property in wound disinfection model.