Synthesis and Characterization of 3-(5-Substituted-2,4-dioxo-3,4-dihydro-2H-pyrimidin-1-yl)-Propionic Acid Ethyl Esters

7 Aza-Michael adducts, 3-(5-substituted-2,4-dioxo-3,4-dihydro-2H-pyrimidin-1-yl)-propionic acid ethyl esters were synthesized by 5-subtituted uracils and ethyl acrylate with ammonia as a catalyst. It was significant that the synthetic compounds were collected in almost quantitive yields without column chromatography. The structures of the compounds were determined by NMR, mass spectra, X-ray crystallography analyses and elemental analyses.