Copper-catalyzed synthesis of 3-substituted isocoumarins from 2-halogenation benzoic acid and alkynes

A method for synthesizing 3-substituted isocoumarins under copper catalysis involves the cyclization reaction of o -bromobenzoic acid and alkynes in DMSO, with the assistance of K 2 CO 3 at 100 °C. It exhibits a wide range of substrate compatibility and excellent tolerance towards diverse functional groups. Graphical abstract A method for synthesizing 3-substituted isocoumarins under copper catalysis involves the cyclization reaction of o-bromobenzoic acid and alkynes in DMSO, with the assistance of K 2 CO 3 at 100 °C. This reaction demonstrates a synthesis yield of 8–81% for 3-substituted isocoumarins.