Research on a kind of biocompatible molecularly imprinted materials with silybin controlled release based on pH/temperature dual responses

Silybin , a hepatoprotective active natural ingredient, was used as the template , methyl acrylic acid (MAA) as the functional monomer , n-isopropyl acrylamide (NIPAm) as the thermal response monomer , magnetic core Fe 3 O 4 @CS@APTES@BiBB coated by biocompatible chitosan as the carrier, and a kind of silybin molecularly imprinted materials (MMIPs) based on pH/temperature dual responses were prepared by electron transfer activation regenerative catalyst atom transfer radical polymerization (ARGET ATRP). The synthesized material was characterized by FT-IR, TGA , SEM, XRD , VSM, and XPS , and the loading behavior of silybin in MMIPs could be explained by the pseudo-second-order kinetic model . The selectivity factor α (2.636) and the relative selectivity factor β (2.468) indicated MMIPs had good specific recognition ability for silybin. In addition, a series of experimental data displayed MMIPs had many other excellent characteristics such as adsorption property, swelling performance, biocompatibility , degradability , stability, reproducibility and so on. The cumulative release rates of MMIPs could reach 29%, 23% and 25% in the media of pH 1.0, 7.4 and 8.2 at 37.5 °C, resepectively, and when the temperature was raised to 43 °C, the release rate of MMIPs in solution (pH 7.4) reached 49%, which indicated that the carrier material had good pH/temperature dual responses.