Preparation of enantiomerically pure α-hydroxyl phosphinates via hydrophosphorylation of aldehydes with H-phosphinate

The hydrophosphorylation of aldehydes with a P -stereogenic H -phosphinate was realized by heating two compounds in a neat state or catalyzed by a base , to afford P -retention α-hydroxyl phosphinates. The ( S P , S C ) and other diastereomers were isolated, and their structures were confirmed by NMR spectroscopy and crystallography.