Hypoglycemic effect of oral crude tea flower polysaccharides on alloxan modeling Sprague–Dawley rats and the possible mechanism

This article mainly focused on the hypoglycemic effects of green tea flower polysaccharides (TFPS) and their possible mechanisms about regulating concentration of blood glucose. An alloxan-induced Sprague–Dawley (SD) rat model was used to observe the change in blood glucose. Inhibition rate of α-amylase and α-glucosidase, and antioxidant ability of TFPS were also tested to explain the possible mechanism. The results showed that TFPS could reduce blood glucose in alloxan-treated rats. TFPS had strong hydrogen donor ability and could protect cell membrane from overoxidation. TFPS could also inhibit the activity of α-amylase and α-glucosidase in vitro. But the inhibition of α-amylase by TFPS was comparatively low. It suggested that TFPS could protect against rapid blood glucose rise in alloxan-induced SD rats. The possible mechanism was that TFPS not only could donate hydrogen to protect SD rats from oxidative damage, but also inhibit digestive enzymes activities.