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Efficient Synthesis of Apigenin

Journal 2013 · IF 0.596 · 发表于 2013 年 11 月 1 日
作者: Ji Zhang,Man Liu,Wei Cui,Jian Yang,Xia-li Liao
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摘要

An efficient synthesis of apigenin using 1,3,5-trimethoxybenzene and anisaldehyde as starting materials is described, involving Friedel–Crafts acylation, selective demethylation, cyclisation, and demethylation. This transformation features a new method for the deprotection of methyl ethers. The overall yields reached approximately 55%.