Polyethyleneimine-modified electrospun SnC for the detection of ovalbumin

Based on the electrostatic spinning process, a boronic acid-functionalized electrochemical sensor was designed. Polyethylenimine (PEI) was introduced into the electrospinning solution, which promoted the formation of fine particulate coatings from tin hydrolysis products. These particles were effectively anchored onto the nanofiber surfaces, resulting in a unique morphology that significantly increases the active sensing area. Boronic Acid Bonds Grafted onto Material Surfaces can effectively capture substances containing vicinal diols. By combining with molecular imprinting (MIP) which features specific imprinted cavities, this approach enables the capture of OVA. The blocking of these cavities leads to a change in the current response, thus achieving detection. The sensor demonstrates excellent selectivity and sensitivity, with a detection limit of 1.3 fg/mL. It can be applied to detect OVA in egg-free bread, showcasing certain practical detection capabilities.