Antineutrophil Cytoplasmic Antibodies Contribute to Airway Inflammation via Induction of Neutrophil Extracellular Traps in Children With Bronchiolitis Obliterans

This study demonstrates that antineutrophil cytoplasmic antibodies (ANCA) induce neutrophil extracellular traps (NETs) in children with bronchiolitis obliterans (BO). NETs promote airway epithelial inflammation and cytokine release, contributing to chronic airway injury. These findings reveal a novel mechanism by which ANCA may drive inflammatory pathology in BO.