GNRs/Ti3C2 MXene improved optical fiber LSPR acetylcholine biosensors

The rapid, accurate and highly sensitive detection of acetylcholine, which was one of the neurotransmitters related to a variety of neurodegenerative diseases has great significance for disease screening, treatment and prognosis. This paper proposed a GNRs/Ti 3 C 2 MXene enhanced optical fiber LSPR acetylcholine biosensor by depositing Ti 3 C 2 MXene nanosheets on the surface of a GNRs-based optical fiber sensing probe via simple electrostatic self-assembly. The refractive index sensitivity of the biosensor was improved due to the advantages of the large specific surface area, hydrophilicity and broadband absorption spectrum of 2D Ti 3 C 2 MXene nanosheets. The refractive index sensitivity of the biosensor with Ti 3 C 2 MXene nanosheets was improved by 44 % compared to that of the GNRs-based biosensor. The biosensor had a good linear relationship in the range of 0–900 μM for acetylcholine concentration with a sensitivity of 0.0304 nm/μM and the detection limit was 6.58 μM. The results indicated that the proposed GNRs/Ti 3 C 2 MXene enhanced optical fiber LSPR acetylcholine biosensor provides a promising avenue of detection for in biotechnology and medicine files.