Multifunctional natural Herbal Extracts Lamiophlomis rotata (Benth.) Kudo composite gel for infected wounds healing

Wounds are susceptible to persistent infections and chronic inflammation, which can significantly impeding the healing process. Lamiophlomis rotata (Benth.) Kudo (LR), a traditional Tibetan medicine, is known for its efficacy in treating injuries, contusions, and skin ulcers. Existing LR-related formulations such as capsules and patches are primarily used for pain relief and cannot provide an optimal environment for infected wounds, thereby limiting their healing potential. In this study, we successfully extracted an extract of LR and confirmed its strong antibacterial activity, supporting its use in infected wound management. A gel matrix was developed using carbomer 940 (CP940) as the base, along with glycerol, 1,2-propanediol, and other excipients. The LR was incorporated into this matrix to obtain Lamiophlomis rotata (Benth.) Kudo gel (LR Gel). Rheological experiments characterized the adhesion and mechanical strength of LR Gel, confirming that it possesses sufficient adhesive force and mechanical strength to tightly adhere to and protect the wound site. Animal experiments showed that LR Gel effectively modulates immune activity and significantly promotes healing in a rat model of infectious full-thickness skin defects. These findings indicate that the LR Gel can prevent wound infection and secondary damage, offering a safe and efficient treatment for infected wounds with promising clinical application.