Photothermal-Responsive Supramolecular-Driven Hydrogel for Controlled Drug Release

Achieving precise and controllable drug release remains a significant challenge for hydrogel dressings. In this study, the hydrogel network was modified with functionalized cyclodextrin to enhance its thermal responsiveness and shrinkage capacity. Additionally, cuttlefish ink nanoparticles were incorporated as a natural photothermal agent to enable precise temperature regulation. As a result, the modified hydrogel exhibited controllable drug release behavior within a temperature range of 36 to 46.5 °C. Under this strategy, a shrinkage ratio of 60.54% and gallic acid release rate of 85.17% were achieved. Furthermore, the hydrogel demonstrated antibacterial performance (>90%), high biocompatibility (cell viability >90%), and significant antioxidant activity. This hydrogel system shows significant potential for application in intelligent drug delivery platforms, infected wound dressings, and combined photothermal therapy.