Sequential drug-releasing electroactive wound dressing accelerates healing of diabetic infected wounds through microenvironmental remodeling

Effective remodeling of the wound regenerative microenvironment is pivotal for achieving rapid and high-quality healing in diabetic wounds. Yet, current therapeutic strategies are largely constrained by their inability to orchestrate temporally programmed drug delivery that aligns with the dynamic and stage-specific demands of the healing process. To address this challenge, we engineered a sequentially dual-drug releasing wound dressing (PCC-PF), designed to deliver time-resolved biochemical and biophysical cues that reprogram the regenerative microenvironment and accelerate wound repair. The PCC-PF scaffold markedly enhanced the regenerative activity of key cell populations, including fibroblasts and endothelial cells, while fostering a favorable tissue microenvironment. Importantly, dual-phase delivery of the incorporated drugs accelerated the closure of infected wounds in diabetic rats. This sequential drug release strategy, enabling precise and dynamic microenvironmental remodeling, presents a promising paradigm for advancing the clinical management of diabetic wounds.