Infinite Coordination Polymer @MOFs Nanocomposites for Highly Cost-Effective Tumor Therapy Utilizing Synchronously Electrothermal-Photodynamic Induced Mutually Reinforcing Strategy

Multimodal tumor therapies suffer from poor spatial co-localization, asynchronous activation, and weak cross-modal reinforcement, leading to limited therapeutic efficiency. Here, we report a photoelectric therapy needle (PTN) system that achieves in situ synchronous electrothermal-photodynamic therapy (synchronous ETT-PDT) and amplifies chemotherapeutic efficacy through hierarchical cross-modal and cross-component reinforcement. The PTN integrates optical fibers and heating wires within a single hollow needle, enabling precise, spatiotemporally synchronized activation under ultralow energy (0.2 V, 0.1 W cm −2 ). We further designed hyaluronic acid-modified MOF@infinite coordination polymer nanocomposites (HA-MOF@ICP NCPs) co-loaded with ICG, SN38, and AQ4N for sequential release. This structure allows PDT-induced hypoxia to activate AQ4N, while ETT enhances SN38 cytotoxicity, establishing a bidirectional ETT↔PDT reinforcement and multi-level drug synergy. In vivo, PTN-NCPs achieved complete eradication of large tumors (≈300 mm 3 ) within 21 days using one-tenth conventional PDT energy and minimal drug doses (1/2.5 AQ4N, 1/12.5 SN38), with no recurrence over 60 days. Four parameters of toxicity, energy, dosage and therapeutic effect were selected and normalized to assess the cost-effective degree of our mutually reinforcing strategy. Compared with the results of prior trimodal strategies, our mutually reinforcing strategy had the largest cost-effective degree value (1.6–10.9 times high), achieving high cost-effective tumor comprehensive therapeutic outcomes.