Milk fat globule—EGF factor 8/ATP‐binding cassette subfamily E member 1 axis maintains mitophagy flux homeostasis to suppress ferroptosis in acute pancreatitis

During AP, MFG‐E8 expression in pancreatic acinar cells is downregulated, resulting in disruption of the ABCE1/MFG‐E8 complex. This impairment leads to defective mitophagy flux, accumulation of lipid peroxides, endoplasmic reticulum stress and ferroptosis, ultimately contributing to pancreatic damage .