Highly sensitive enantiomeric detection of tryptophan using microchannel-based chiral sensors

A novel microchannel-based chiral sensor leveraging silica nanowires self-assembled with maltosyl-cyclodextrin (SiNWs/G2-β-CD) on glass microchannel (GMC) is reported. This innovative SiNWs/G2-β-CD/GMC sensor achieves ultrasensitive detection of L-tryptophan over a wide linear range (1-10 5 aM) with exceptional selectivity, enabling accurate discrimination in mixtures of tryptophan enantiomers. Its application to milk sample analysis demonstrates high recognition performance and practical reliability. The SiNWs/G2-β-CD/GMC sensor offers a rapid, cost-effective, and highly sensitive platform, holding great promise for dietary monitoring and enantiomeric analyses in complex matrices. Section Graphical