Developing electrochemical sensors and portable system based on CoCu-LDH/FCF and screen-printed electrodes for non-enzymatic glucose detection

Accurate monitoring of blood glucose concentration is crucial for diabetes diagnosis. In this work, a three-dimensional hierarchical structure was fabricated by incorporating CoCu-layered double hydroxide onto flexible carbon foam (CoCu-LDH/FCF). Its porous, sponge-like architecture provides a high specific surface area and exposes abundant catalytic sites, thereby enhancing electrocatalytic performance for glucose sensing. The CoCu-LDH/FCF composite was immobilized onto a screen-printed electrode (SPE) to construct a portable sensor, designated as CoCu-LDH/FCF/SPE. The resulting sensor exhibits excellent electrocatalytic activity toward glucose oxidation, featuring a linear detection range of 2–500 μM, a sensitivity of 25.6 μA·μM −1 ·cm −2 , favorable selectivity, and long-term stability. Furthermore, a portable detection platform was developed by integrating the sensor with a flexible electrochemical integration module and a smartphone. Experimental results demonstrate the high performance of the CoCu-LDH/FCF/SPE sensor within this compact system.