A novel multifunctional and low toxicity Tb-MOF used for extremely sensitive detection of aspartic acid, ethyl maltol and rotenone in complex matrices

Developing sensitive and biocompatible detection technologies is important for public health management and risk assessment. In this investigation, a new multifunctional Tb-MOF fluorescent nanomaterial was constructed, which has excellent structural stability and luminescent performance. It can achieve highly sensitive detection of three key target substances - aspartic acid, ethyl maltol, and rotenone in complex matrices, with detection limits as low as 16.0, 14.5, and 48.0 nM respectively. The Tb-MOF exhibited successful application in real samples such as infant formula, peanut oil, and artificial serum with satisfactory recovery rates (92.49%–103.1%). It is worth noting that the cytotoxicity experiment further confirmed its low toxicity, supporting its safe application in the biological body.