Boronic acid-decorated magnetic porous organic polymer for the improved adsorption of phenolic endocrine disruptors in milk

The sensitive detection of trace endocrine disruptors holds immense practical significance for safeguarding food safety. Herein, a boronic acid-decorated magnetic porous organic polymer (POP-PA@Fe 3 O 4 ) was synthesized as adsorbent for the extraction and enrichment of several phenolic endocrine disruptors (PEDs). The decoration of boronic acid provides a high density of hydroxyl groups, significantly enhancing its adsorption performance. POP-PA@Fe 3 O 4 exhibited excellent adsorption capability toward PEDs by virtue of H-bonding interactions and π-π stacking. Subsequently, combined with high-performance liquid chromatography/mass spectrometry (HPLC/MS), a sensitive method for the determination of PEDs in milk was established by employing POP-PA@Fe 3 O 4 as a magnetic extraction adsorbent. The method showed low detection limits (S/ N = 3) of 0.080–0.40 ng·mL −1 . The recoveries of spiked samples spanned 84.6% to 100.0% with RSD ≤ 7.5%. This work presents a feasible approach for the detection of PEDs in milk and further expands the application of functionalized porous organic polymers in food safety monitoring.