Tailoring triazine-based covalent organic framework with hydroxyl sites for effective extraction and sensitive detection of phenolic endocrine-disrupting compounds

Phenolic endocrine disrupting compounds (PEDCs) are associated with significant health hazards, necessitating the development of highly sensitive analytical detection methodologies‌. This study reported a novel covalent organic framework (DT-COF) by strategically incorporating hydroxyl-rich building blocks into π-conjugated architectures. DT-COF demonstrated enhanced adsorption effect for PEDCs through the multiple hydrogen bond binding and multiple π-π interaction sites. By using DT-COF as a solid phase extraction adsorbent and integrating it with high performance liquid chromatography tandem the mass spectrometry, a robust analytical platform was provided to determine the trace PEDCs in green tea beverages, bottled water, and milk. Under optimized conditions, the method exhibited excellent analytical performance, including a low detection limit (0.018–0.219 ng mL −1 ), good recovery rates (86.3–109%), and outstanding reproducibility (RSDs ≤6.6%). This study achieves dual objectives: enabling sensitive detection of PEDCs contaminants while pioneering functional COF material development.