Surface molecularly imprinted PVA@CS-MIPs membrane for selective recognition and adsorption of creatinine

The elevation of creatinine in the blood is a typical indicator of renal dysfunction, and persistent renal insufficiency can eventually develop into kidney failure, requiring patients to rely on dialysis or kidney transplantation to maintain their lives. This study focuses on the preparation and performance evaluation of a molecularly imprinted membrane, PVA@CS-MIPs, designed for selective adsorption of creatinine. The PVA@CS-MIPs membrane was fabricated using PVA/CScomposite base membrane prepared via solution casting, with α-methylacrylic acid (MAA) as the functional monomer, N,N′-methylenebisacrylamide (MBA) as the crosslinker, and cerium ammonium sulfate (ACS) and concentrated sulfuric acid as initiators. The PVA@CS-MIPs membrane was characterized using FT–IR, SEM, and XPS. The adsorption and permeation behaviors of PVA@CS-MIPs were investigated, and the underlying mechanisms were discussed. The results demonstrate that PVA@CS-MIPs exhibit a high adsorption capacity of 322.5 mg/g for creatinine and good adsorption selectivity. Moreover, the membrane exhibits excellent reusability. These findings suggest that the prepared PVA@CS-MIPs possesses specific recognition ability forcreatinine and hold promise for applications in hemodialysis-related fields.