A Poly L-Arginine/β-Cyclodextrin Molecularly Imprinted Nanocomposite for Highly Sensitive Electrochemical Detection of Acetaminophen

A poly L -arginine/β-cyclodextrin molecularly imprinted polymer-modified graphite electrode (PL-Arg/β-CD MIPs/GE) was developed for sensitive acetaminophen detection. The sensor achieved a wide linear range of 0.1–200 μmol L –1 and a low detection limit of 0.022 μmol L –1 , attributed to synergistic enrichment and electron transfer. It demonstrated excellent selectivity, reproducibility, and high recovery (98.20–102.80%) in real-sample analysis, showing great promise for practical drug monitoring applications.