A highly sensitive sensor inspired by the papillary structure of cactus for simultaneous detection of glucose and H2O2

Electrochemical detection sensor is designed with bionic papillary array structure. • Unique structure significantly increases the internal oxygen vacancy concentration. • The sensor enables the simultaneous and selective detection of glucose and H 2 O 2 . • The sensor offers wide detection range and achieve precise analysis in human blood. Designing an electrochemical sensor with high sensitivity and the ability to simultaneously detect multiple biomarkers is a challenging and significant research. Inspired by the water collection function of cactus papillary structures, a high-performance sensor (MCeO 2 @γFe 2 O 3 sensor) featuring a sponge-like nanoporous architecture and a bionic papillary array was constructed based on the CeO 2 @γFe 2 O 3 composite structure with lattice shap. The composite structure has transition metal carbide (MXene) as the framework and CeO 2 @γFe 2 O 3 composite nanoparticles as attachments. The sensor exhibits enhanced redox reaction activity, which is attributed to the combination of its unique microstructure and the substantial increase in oxygen vacancy concentration within the crystal lattice following recombination. This contributes to its superior detection performance in comparison to conventional electrochemical detection sensors. Its sensitivity is 11.0 mA mM −1  cm −2 (glucose detection) and 1.10 mA μM −1  cm −2 (H 2 O 2 detection). It features the low limit of detection (glucose: 0.25 μM, H 2 O 2 : 0.010 nM) and the ultra-wide linear detection range (glucose: 1.0 mM–40.0 mM, H 2 O 2 : 0.10 nM-1.0 × 10 2  μM), which can meet the needs of blood glucose and H 2 O 2 level detection. In addition, the sensor is capable of simultaneously detecting glucose and H 2 O 2 , demonstrating excellent selectivity, consistency, durability (300 cycles) and the potential to achieve accurate detection in the human blood environment. This study proposes a novel strategy for the development of an integrated high-performance sensor that enables simultaneous multi-biomarker detection, opening new avenues for innovation in blood testing technology. Download: Download high-res image (160KB) Download: Download full-size image