N-Alkylation of phosphinic amide enabled by bis(NHC)Mn catalysis: A BH/HA-mediated efficient route to bioactive molecules

A bis(NHC)Mn-catalyzed N-alkylation method for phosphinic amide synthesis has been developed in this work. By utilizing the borrowing hydrogen/hydrogen autotransfer (BH/HA) process, 24 examples with good to excellent yields have been obtained. This method has been demonstrated to be versatile and efficient, enabling new syntheses of bioactive molecules and functional materials, as well as the conversion of simple alcohols into complex organics.