Application of pH-enhanced MIL101@ICG@FA for enhanced cellular uptake in tumor combination therapy

Malignant tumors remain a major global health burden due to high mortality and limited therapeutic efficacy. Nanomaterials offer promising strategies for cancer treatment owing to their tunable physicochemical properties. In this study, a multifunctional MIL-101@ICG@FA nanocomposite was constructed to integrate photothermal, photodynamic, and chemodynamic therapies. The Fe-based MOF exhibited high porosity and loading capacity, enabling effective incorporation of indocyanine green. The nanoplatform displayed strong photothermal conversion, enhanced reactive oxygen species generation, and Fenton-like catalytic activity under near-infrared irradiation. In-vitro assays demonstrated potent cytotoxicity against tumor cells, while in-vivo experiments confirmed efficient tumor growth inhibition with no obvious toxicity observed in the short-term evaluation. These findings highlight the synergistic therapeutic advantages of MIL-101@ICG@FA and support its potential as a promising candidate for multimodal cancer therapy.