PDA@CeMn nanozyme for enhanced myocardial protection via ROS scavenging and inflammation suppression

The mortality rate of cardiovascular diseases (CVD) remains alarmingly high. Studies have shown that reactive oxygen species (ROS)-mediated inflammatory responses and oxidative stress are key pathological mechanisms driving CVD. Nanozymes, nanomaterials with enzyme-like activities, offer several advantages over natural enzymes, including enhanced stability and scalability. Previous research has demonstrated that nanozymes containing cerium (Ce) or manganese (Mn) possess excellent ROS-scavenging capabilities. Dopamine, a positive inotropic agent commonly used in clinical practice to improve cardiac function in patients with heart failure, has also been shown to self.