Metal–Organic Framework-Derived ZnCoP Nanopolyhedra as an Efficient Electrocatalyst for Electrochemical Dopamine Detection

Rapid and efficient detection of dopamine is crucial for disease prevention and clinical diagnosis. Herein, ZnCoP nanopolyhedra synthesized via a metal–organic framework (MOF)-derived phosphidation route are employed as an electrocatalyst for electrochemical dopamine sensing. The constructed sensor exhibits outstanding analytical performance, featuring a wide linear range (0.5–1500 μM), high sensitivity (1038 μA mM −1 cm −2 ), and a low detection limit of 0.19 μM. Additionally, the sensor demonstrates excellent selectivity, long-term stability, and reliable repeatability. The superior performance is attributed to the well-defined polyhedral architecture inherited from the MOF precursor, which offers abundant electroactive sites and facilitates efficient electron transfer. These results establish ZnCoP nanopolyhedra as a promising sensing platform for dopamine detection, with strong potential for applications in medical diagnostics and bioanalytical monitoring. Graphical Metal–organic framework (MOF)-derived ZnCoP nanopolyhedra are synthesized via a direct phosphidation strategy and serve as an efficient electrocatalyst for dopamine detection. The material retains the polyhedral morphology of the MOF precursor with a roughened surface, providing abundant active sites and enhanced conductivity. Benefiting from these features, the electrochemical sensor delivers a wide linear range (0.5–1500 μM), a low detection limit (0.19 μM), and high sensitivity (1038 μA mM −1 cm −2 ), along with excellent selectivity, stability, and reproducibility.