摘要
The discovery of gold nanoparticles as precious-metal photothermal materials has aroused great interest in morphology regulation, especially in the emerging anisotropic morphology of gold nanoparticles. In this study, the influence of the local surface plasmon resonance effect on the photothermal conversion ability of gold nanoparticles with different morphologies is investigated. This study is based on gold nanobipyramids—a nanostructure with excellent photothermal conversion efficiency. It compares two strategies for preparing gold nanobipyramids and explores how morphology and growth mechanisms are regulated by varying the gold seed concentration and the ascorbic acid-to‑silver nitrate molar ratio. Subsequently, the biocompatibility of the nanoparticles was enhanced by capping mesoporous polydopamine onto the periphery of the gold nanobipyramids, and their chemotherapeutic capability was endowed via loading the drug doxorubicin (DOX) into the mesoporous structure; the drug loading capacity and encapsulation efficiency were 45.1% and 82.0%, respectively. In order to improve the therapeutic efficacy of the nanocarriers in the tumor microenvironment, the pH-responsive property of polyethylenimine (PEI) was incorporated into AuNBP@mPDA to confer targeted drug release capability. Surprisingly, the PEI layer effectively seals the mesoporous structure and prevents premature drug release, thereby enabling precise drug delivery. After a series of structural characterizations and performance evaluations, the final AuNBP@mPDA-DOX@PEI nanocarrier was confirmed to exhibit excellent thermochemotherapeutic performance (reduction of Hela S3 cells to 27.1%) and pH-responsive drug release (38.60% cumulative release at pH 5.0), demonstrating its potential for cancer therapy. This combination of photothermal–chemotherapeutic efficacy, pH-responsive release, and high biocompatibility renders the nanocarrier promising for cancer treatment.
危险品化学品经营许可证（带存储）