Synthesis, Structures and Urease Inhibition Studies of Copper(II) and Zinc(II) Complexes Derived from N’-(4-bromo-2-hydroxybenzylidene)-4-Hydroxybenzohydrazide

Two new copper(II) and zinc(II) complexes [Cu 2 (bhb) 2 (CH 3 OH) 2 ] ( 1 ) and [Zn(Hbhb) 2 ]·4CH 3 OH ( 2 ), where bhb and Hbhb are the dianionic and monoanionic forms of N ’-(4-bromo-2-hydroxybenzylidene)-4-hydroxybenzohydrazide (H 2 bhb), respectively. The two complexes are characterized by elemental analysis and physico-chemical method, as well as single crystal X-ray diffraction. The Cu atom in complex  1 is in square pyramidal coordination, and the Zn atom in complex  2 is in octahedral coordination. The compounds are tested for their urease inhibitory properties. The copper complex has strong activity ( IC 50  = 1.7 ± 0.3 μM). The alternative text for this image may have been generated using AI.