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VMAT‐DAT‐Dopamine Regulatory System Involved in the Protective Effect of 3‐n‐Butylphthalide Against Ischemic Stroke

Journal 2026 · IF 6.6 · 32(8): e71094 · 发表于 2026 年 8 月 18 日
作者: Xiao‐Ting Zhou,Qin Liu,Ming Chen,Ruo‐Xi Zhang,Yi‐Ling Su,Ding‐Feng Su,Ai‐Jun Liu
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摘要

Proposed mechanism underlying NBP protection against ischemic stroke. NBP exerts neuroprotection against cerebral ischemic injury partially via upregulating the VMAT‐DAT‐dopamine cycle to improve synaptic dysfunction. Activation of D 1 R and adenosine A 1 Rs participates in the relevant downstream signalling cascades.