摘要
Oxygen-vacancy TiO 2 was prepared via inert-atmosphere annealing. • TA-Ce metal-phenolic network was deposited on micro-arc oxidized Ti. • Coatings showed enhanced near-infrared photothermal antibacterial activity. • Coatings scavenged ROS and promoted osteogenic differentiation. Titanium-based implants are widely used for bone repair but still face challenges including bacterial infection, oxidative stress, and insufficient osseointegration. In this study, a tannic acid-cerium (TA-Ce) metal-phenolic network was deposited onto an oxygen-vacancy-rich micro/nano-structured TiO 2 coating to construct a bioactive titanium surface. The coating was fabricated through micro-arc oxidation, alkali-heat treatment, inert-atmosphere annealing, and subsequent TA-Ce deposition. Oxygen vacancies enhanced near-infrared (NIR) absorption and photothermal conversion, while the TA-Ce network further improved photothermal responsiveness and antioxidant activity, under 808 nm NIR irradiation, the modified coating exhibited excellent photothermal antibacterial performance against both Staphylococcus aureus and Escherichia coli . In addition, the coexistence of Ce(Ⅲ)/Ce(Ⅳ) and phenolic groups enabled efficient reactive oxygen species scavenging, reducing extracellular and intracellular oxidative stress. In vitro studies further demonstrated favorable cytocompatibility and enhanced osteogenic differentiation, including increased alkaline phosphatase activity, collagen secretion, and mineralization. Overall, this study provides a simple and effective strategy for developing titanium implant surfaces with combined antibacterial, antioxidant, and osteogenic properties, offering new insights into multifunctional implant design. Download: Download high-res image (175KB) Download: Download full-size image TA–Ce MPNs/TiO₂ Coatings for Multifunctional Antibacterial, Antioxidant and Osteogenic Performance.
危险品化学品经营许可证（带存储）