A Carboxymethyl Chitosan/Tannic Acid@Ag Composite Hydrogel for Gastrointestinal Defect Sealing and Smart Motion Monitoring

en This link goes to a English section zh This link goes to a Chinese section Conductive hydrogels show great potential in flexible electronics and biomedical devices, yet their practical applications are often hindered by insufficient mechanical strength, poor environmental stability, and limited functionality. To address these challenges, this study has developed a hydrogel platform that integrates diagnosis and treatment, enabling real-time monitoring and sealing of gastrointestinal defects. Through a well-designed multi-dynamic network, the hydrogel integrates tissue-like stretchability (fracture strain up to 1420%), strong wet adhesion (adhesion strength 43 kPa), and broad-spectrum antibacterial activity. Leveraging its unique hybrid ionic electronic conductive network, the material enables simultaneous capture of electrophysiological signals (ECG and EMG) and mechanical motions (intestinal peristalsis, cardiac contraction, and gastric activity), achieving multimodal physiological monitoring. Remarkably, while providing a continuous and stable signal sensing, the hydrogel effectively seals gastrointestinal defects, demonstrating excellent defect sealing capability. This work presents a hydrogel platform that breaks through the limitations of conventional single-function materials, offering an innovative solution for closed-loop intelligent diagnostic therapeutic systems, with significant potential in next-generation bioelectronic medicine. 摘要 en This link goes to a English section zh This link goes to a Chinese section 导电水凝胶在柔性电子和生物医学器件领域展现出巨大潜力,但其实际应用常常受到机械强度不足、环境稳定性差以及功能有限等问题的制约。为了解决这些挑战,本研究开发了一种集诊断与治疗于一体的水凝胶平台,可实现胃肠道缺损的实时监测与封闭。通过精心设计的多重动态网络,该水凝胶兼具类组织的高延展性(断裂应变最高可达1420%)、优异的湿态黏附性能(黏附强度为43 kPa)以及广谱抗菌活性。得益于其独特的离子与电子混合导电网络,该材料能够同时采集电生理信号(如心电和肌电)以及机械运动信号(如肠蠕动、心脏收缩和胃部活动),从而实现多模态生理监测。值得注意的是,在提供连续稳定信号感知的同时,该水凝胶还能有效封闭胃肠道缺损,表现出优异的缺损封闭能力。该研究提出了一种突破传统单一功能材料局限的水凝胶平台,为构建闭环式智能诊疗系统提供了创新性解决方案,在下一代生物电子医学中具有重要应用潜力。