Chemosensors
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2023
·Vol. 11
·期 12
·573
·
IF 4.2
Hanwen Ren,Xiansu Liu,Shanshan Wei,Feijun Zhao,Zhencheng Chen,Haolin Xiao
The progression of Alzheimer’s disease (AD) is positively correlated with the phosphorylation damage of Tau-441 protein, which is the marker with the most potential for the early detection of AD. The low content of Tau-441 in human serum is a major difficulty for the realization of content detection. Herein, we prepared an electrochemical immunosensor modified with Poly(3,4-ethylene-dioxythiophene)-poly (styrene sulfonate) (PEDOT: PSS)/Carboxylated multi-walled carbon nanotube (MWCNTs-COOH) nanocomposites based on electrochemical immunoassay technology for the low-concentration detection of Tau-441. The immunosensor based on the nanocomposite can take advantage of the characteristics of conductive polymers to achieve electrical signal amplification and use MWCNTs-COOH to increase the contact area of the active site and bond with the Tau-441 antibodies on the electrode. The physicochemical and electrical properties of PEDOT: PSS/MWCNTs-COOH were studied by in situ characterization techniques and electrochemical characterization methods, indicating that the immunosensor has high selectivity and sensitivity to the Tau-441 immune reaction. Under optimized optimal conditions, the electrochemical immunosensor detected a range of concentrations of Tau-441 to obtain a low detection of limit (0.0074 ng mL−1) and demonstrated good detection performance through actual human serum sample testing experiments. Therefore, the study provides an effective reference value for the early diagnosis of AD.Keywords:PEDOT: PSS;MWCNTs-COOH;nanocomposites;electrochemical immunosensor;Tau-441
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高影响因子
Chemosensors
·
2025
·Vol. 13
·期 7
·251
·
IF 3.7
Zizi Zhao,Wei Qu,Chengjun Qiu,Yuan Zhuang,Kaixuan Chen,Yi Qu,Huili Hao,Wenhao Wang,Haozheng Liu,Jiahua Su
Excessive levels of Pb2+and Cd2+in seawater pose significant combined toxicity to marine organisms, resulting in harmful effects and further threatening human health through biomagnification in the food chain. Traditional methods for detecting marine Pb2+and Cd2+rely on laboratory analyses, which are hindered by limitations such as sample degradation during transport and complex operational procedures. In this study, we present an electrochemical sensor based on intelligent mobile detection devices. By combining G-COOH-MWCNTs/ZnO with differential pulse voltammetry, the sensor enables the efficient, simultaneous detection of Pb2+and Cd2+in seawater. The G-COOH-MWCNTs/ZnO composite film is prepared via drop-coating and is applied to a glassy carbon electrode. The film is characterized using cyclic voltammetry, electrochemical impedance spectroscopy, and scanning electron microscopy, while Pb2+and Cd2+are quantified using differential pulse voltammetry. Using a 0.1 mol/L sodium acetate buffer (pH 5.5), a deposition potential of −1.1 V, and an accumulation time of 300 s, a strong linear correlation was observed between the peak response currents of Pb2+and Cd2+and their concentrations in the range of 25–450 µg/L. The detection limits were 0.535 µg/L for Pb2+and 0.354 µg/L for Cd2+. The sensor was applied for the analysis of seawater samples from Maowei Sea, achieving recovery rates for Pb2+ranging from 97.7% to 103%, and for Cd2+from 97% to 106.1%. These results demonstrate that the sensor exhibits high sensitivity and stability, offering a reliable solution for the on-site monitoring of heavy metal contamination in marine environments.
研究领域:
环境监测
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电化学
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传感器
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海洋污染
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分析化学
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高影响因子
Nano Energy
·
2024
·
IF 16.8
Hongyu Chen,Zengxuan Chen,Shoufu Cao,Zhaojie Wang,Xiaodong Chen,Xiaojing Lin,Qi Hou,Shuxian Wei,Siyuan Liu,Baojun Wei,Xiaoqing Lu
Nitrogen-doped carbon (NC) for carbon dioxide reduction reaction (CO 2 RR) are promising candidates. However, its selectivity and activity are limited by the undeveloped pore and limited electronic effect. Herein, we propose a strategy of three birds with one stone to utilize the embedded nickel for inducing electron-rich pyridinic-NC with multimodal porous structure based on the hard template assisted sacrificial template method. Nickel acts as sacrificial agent and inducer to facilitate the formation of mesoporous and reactive nitrogen species for capturing and activating reactants, respectively. Besides, we find that nickel as electron donor endows the NC with electron accumulation for participating actively in PCET reaction. The resultant Ni 0.87 -NC-1-AE exhibits an eminent FE CO of 97.6 % with excellent activity and stability. In-situ Raman spectroscopy and the projected crystal orbital Hamilton populations (pCOHP) confirm the accumulation of *COOH and the stable adsorption of *COOH on the surface. What’s more, the well-designed experiments and DFT calculations accurately locate pyridinic-N as the active site, where the aggregated electrons donated by nickel significantly reduce the energy barrier of rate-determining step and promote the desorption of CO. This work provides an instructive perspective to construct advanced NC electrocatalysts with high mass transfer efficiency and high catalytic activity.
研究领域:
材料科学
·
电催化
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高影响因子
CHEMOSPHERE
·
2022
·
IF 8.943
Liyun Zhang,Yi He,Pingya Luo,Lan Ma,Shuangshuang Li,Yiling Nie,Jing Yu,Xiao Guo
Considering the emulsified oil and water-soluble dyes in wastewater, the exploitation of easy-manufacturing, energy-saving and high-efficiency separation materials is urgently required. In this work, integrating the positively charged polyethyleneimine (PEI) with negatively charged CNTs-COOH constructed the superhydrophilic Cassie–Baxter structure onto the electrospun polyacrylonitrile (PAN) membrane surface by ultrasonic, electrostatic interaction and thermal treatment. Based on it, the PEN@CNTs membrane achieved efficient separation for surfactant-free, tween 80-stabilized, SDS-stabilized, and CTAB-stabilized emulsions (the fluxes reached 508–3158 L m −2 h −1 , the separation efficiency reached 99.42%) by the splendid water-penetration and oil-repellency, electrostatic interaction, and “aperture sieve”. Moreover, because of the porosity and strong charged surface of PEN@CNTs membrane, the anionic dyes can be quickly removed by one-step filtrate method (∼403 L m −2 h −1 ). Meanwhile, the PEN@CNTs membrane also achieved synchronous and efficient remediation for oil/dye mixture emulsions after many cycles. More importantly, facing the complex physical and chemical environments, the combination of the stabilized PEN membrane, inactive CNTs-COOH layer, and the bond of embedding method between CNTs-COOH and PEN nanofibers made the PEN@CNTs membrane demonstrated robust stability and durable separation capability.
研究领域:
环境科学
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材料科学
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水处理
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纳米技术
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PubMed
高影响因子
Journal of Water Process Engineering
·
2025
·
IF 6.7
Yu Yang,Yuanfang Fan,Jinkai Zhang,Shiqiang Liang,Chi Wang,Zhi Geng,Zhongmin Su,Mingxin Huo
In light of the challenges posed by heightened water viscosity and aggravated membrane fouling at low temperatures, this study proposes a novel approach to enhance ultrafiltration (UF) performance. By integrating micro/nano bubbles (MNBs) with UF membrane modification, we aim to mitigate the adverse effects of increased viscosity of feed solution and reduce membrane fouling at low temperatures. Specifically, the utilization of carboxyl-modified poly (aryl ether sulfone) UF membranes enhances water flux and fouling resistance. Our findings indicate that the coupled system maintains comparable flux at both low (5 ± 1 °C) and room (22 ± 1 °C) temperatures, indicating excellent UF permeate performance under low temperatures. Notably, when applied to the cyclic filtration of secondary effluent during winter, the permeate flux of the proposed system surpasses that of the commercial PES UF membrane system by 184.82 %. After three filtration cycles, the permeate flux remains 233.19 % higher than that of the commercial PES UF membrane system, with flux recovery rates ( F RR ) exceeding 90 % in each cycle. These results demonstrate the efficacy of our strategy in addressing the challenges of low-temperature UF, achieving efficient separation processes. Our coupled system represents a promising advancement, offering novel insights and practical solutions for membrane-based water treatment in low-temperature environments.
研究领域:
环境科学
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材料科学
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高影响因子
Journal of Environmental Chemical Engineering
·
2026
·Vol. 14
·期 3
·122376
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IF 7.5
Ying Xue,Qing Liu,Yang Yv,Xiaonan Hao,Yue Wu,Shulin Sun
Wastewater treatment remains a critical global environmental challenge. In this study, zeolitic imidazolate framework-8 (ZIF-8) was first grown in situ on carboxylated carbon nanotubes (CNT-COOH), followed by coating with tannic acid (TA). The CNT-COOH@ZIF-8@TA composite was successfully synthesized. Subsequently, a series of polyvinylidene fluoride (PVDF)/CNT-COOH@ZIF-8@TA (PZC) separation membranes were fabricated by the non-solvent-induced phase separation (NIPS) method. Separation tests demonstrated the high removal efficiencies (>99%) of PZC membranes for methylene blue (MeB) and auramine O (AO) dyes, along with effective retention of corn oil and pump oil emulsions. Furthermore, the engineered PZC membranes exhibited significant adsorption capacity for aqueous dyes, achieving removal rates exceeding 98% for both MeB and AO. The adsorption characteristics and underlying mechanisms were elucidated through kinetic, isothermal, and intra-particle diffusion modeling. Additionally, the PZC membranes demonstrated catalytic activity towards MeB degradation, and the PZC4 membrane achieved a degradation efficiency of 88.3%. Moreover, to enhance membrane longevity, membrane regeneration was achieved through photocatalytic cleaning under UV irradiation, offering an alternative to conventional cleaning methods. This study systematically analyzed the chemical structure, surface morphology, hydrophilicity, and charge properties of the material through multiple characterization techniques, including Fourier Transform Infrared Spectroscopy (FTIR), X-ray Photoelectron Spectroscopy (XPS), Scanning Electron Microscopy (SEM), contact angle measurement, and Zeta potential analysis. The membrane's wastewater purification capability was comprehensively evaluated by combining filtration performance, adsorption experiments, and photocatalytic testing. The designed separation membranes offer promising solutions for the post-treatment of oil spills and the remediation of dye-contaminated wastewater.
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高影响因子
JOURNAL OF MEMBRANE SCIENCE
·
2026
·
IF 9
Zhicheng Wang,Tiansheng Gao,Yuqian Yang,Zizhen Peng,Wenzhong Ma,Qiuyan Bi,Yakai Lin,Hideto Matsuyama
The increasing demand for lithium resources highlights the need for nanofiltration (NF) membranes with high permeability and selectivity for processing salt-lake brines. In this study, an ultrathin Janus NF membrane featuring Li + -selective nanochannels was fabricated via interfacial polymerization for Li + /Mg 2+ separation. Carboxylated cellulose nanocrystals (CNC-COOH) were deposited onto a polyvinylidene fluoride (PVDF) substrate to form an interlayer, and 15-crown-5 (15-C-5) was incorporated into the polyamide (PA) layer, yielding the PVDF/CCNC-15C5-PA membrane. The CNC-COOH interlayer increased membrane hydrophilicity and surface negative charge, and synergistically interacted with 15-C-5 to enhance the interaction with polyethyleneimine, resulting in a thin, defect-free PA layer of approximately 63 nm. Meanwhile, 15-C-5 formed host–guest complexes with Li + , establishing Li + -selective nanochannels that promoted Li + transport. The combined modifications yielded a PVDF/CCNC-15C5-PA membrane with a water permeance of 15.4 L·m -2 ·h -1 ·bar -1 and a Li + /Mg 2+ separation factor of 17.8. This work presents a dual-functional design strategy that integrates interfacial engineering with molecular recognition for advanced ion-selective separation.
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高影响因子
International Journal of Electrochemical Science
·
2023
·
IF 1.5
Ming Zhou,Yong Xu,Rong Zhong,Yurong Wang
A glassy carbon electrode modified by carboxyl-functionalized reduced graphene oxide (ERGO-COOH/GCE) was developed by electrochemical deposition method. The electrochemical behavior of caffeic acid (CA) on the ERGO-COOH/GCE was studied, and an electroanalytical method for the detection of CA in tablets was established. The effects of the modification parameters, the pH of the buffer solution and the scanning rate on the electrochemical behavior of CA were investigated by cyclic voltammetry (CV). The results revealed that modifying the GCE by electrochemical deposition facilitated a more sensitive response to CA on the modified electrode than modifying it by drop coating. The peak current of CA on the ERGO-COOH/GCE was significantly higher than that on the bare glassy carbon electrode (GCE) over five scan cycles, and the optimized the concentration of GO-COOH, the scanning cycles, and the pH were 4 mg·mL -1 , 5 cycles, and 2.0, respectively. The redox reaction of CA on the modified electrode was a quasi-reversible process controlled by adsorption and involved the transfer of two electrons and two protons. The ERGO-COOH/GCE showed a linear response to CA in the range of 0.05 ~ 20 μM with a limit of detection of 8 nM ( S/N =3). The modified electrode exhibited good repeatability and reproducibility and anti-interference performance. The ERGO-COOH/GCE was applied to the detection of CA in caffeic acid tablets with a recovery of 97.7% ~ 108%.
研究领域:
分析化学
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电化学
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生物传感
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药物分析
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纳米材料
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电分析化学
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药剂学
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高影响因子
Nanomaterials
·
2025
·Vol. 15
·期 2
·146
·
IF 4.3
Ying Liu,Zhipeng Zhang,Yuling Wu,Huan Yang,Jiao Qu,Xiaolin Zhu
The disinfection of drinking water is essential for eliminating pathogens and preventing waterborne diseases. However, this process generates various disinfection byproducts (DBPs), which toxicological research indicates can have detrimental effects on living organisms. Moreover, the safety of these DBPs has not been sufficiently assessed, underscoring the need for a comprehensive evaluation of their toxic effects and associated health risks. Compared to traditional methods for studying the toxicity of pollutants, emerging electrochemical sensing technologies offer advantages such as simplicity, speed, and sensitivity, presenting an effective means for toxicity research on pollutants. However, challenges remain in this field, including the need to improve electrode sensitivity and reduce electrode costs. In this study, a pencil graphite electrode (PGE) was modified with carboxylated multi-walled carbon nanotubes (MWCNT-COOH) and nano-iron (III) oxide (α-Fe2O3) to fabricate a low-cost electrode with excellent electrocatalytic performance for cell-active substances. Subsequently, a novel cellular electrochemical sensor was constructed for the sensitive detection of the toxicity of three drinking water DBPs. The half inhibitory concentration (IC50) values of 2-chlorophenylacetonitrile (2-CPAN), 3-chlorophenylacetonitrile (3-CPAN), and 4-chlorophenylacetonitrile (4-CPAN) for HepG2 cells were 660.69, 831.76, and 812.83 µM, respectively. This study provides technical support and scientific evidence for the toxicity detection and safety assessment of emerging contaminants.
研究领域:
环境科学
·
分析化学
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毒理学
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PubMed
高影响因子
ChemNanoMat
·
2023
·Vol. 9
·期 5
·e202200569
·
IF 3.8
Yanyu Li,Xiaoyue Zhang,Jinglin Shen,Wei Qi
Graphical A new type of nanocomposite enzymes has been developed, composed of Pd−Pt nanoparticles, hemin-rGO and CNTs-COOH. The nanocomposites show a high peroxidase-like activity and a linear response toward H 2 O 2 in the range of 0.05–500 μM with a determination limit of 0.01 μM. Based on this, a paper sensor was constructed for H 2 O 2 detection in real samples. Nanocomposite enzymes are attracting intensive attention worldwide. In the present study, a novel colorimetric H 2 O 2 paper sensor was developed based on a new type of nanocomposites composed of Pd−Pt nanoparticles, hemin functionalized reduced graphene oxide (hemin-rGO) and carboxylated carbon nanotubes (CNTs-COOH). The proposed nanocomposites show a high peroxidase-like activity. It provides a sensitive platform showing a linear response toward H 2 O 2 in the range of 0.05–500 μM with a determination limit of 0.01 μM. Based on this, the composites were applied to construct a paper sensor for H 2 O 2 detection in real samples. The cost-effectiveness, simplicity and efficiency of this paper sensor could be developed for “point-of-care” analysis and other related areas.
研究领域:
生物化学
·
分析化学
·
材料科学
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高影响因子
Journal of Materials Chemistry B
·
2024
·
IF 6.1
Jiarong Guo,Ying Ma,Tongyu Han,Jiao Yang,Peng Miao
Metal–organic frameworks (MOFs) with fit ligands and metals can be integrated into electrochemical biosensors for the detection of various biomolecules. In this study, we have synthesized novel magnetic MOF composites as electrocatalysts and constructed a novel biosensor for electrochemical detection of dopamine. The composites named Fe3O4@ZIF-8@AuNPs–COOH are synthesized through layer-by-layer assembly. They exhibit excellent stability and cooperative catalytic activity. In addition, green recycling is readily achieved through magnetizing/demagnetizing the electrode. The large specific surface area and ordered porous structures of the magnetic MOFs ensure good dispersion of gold nanoparticles, while the carboxyl group efficiently shields other redox-active interfering substances. The proposed electrochemical biosensor accomplishes the sensitive detection of dopamine in human serums and living cells. This study broadens the application of MOFs in electrochemical biosensing, validates the feasibility of biosensors for in vivo analysis, and provides new insights into green sensing.
研究领域:
材料科学
·
电化学
·
生物传感器
·
分析化学
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DOI
PubMed
高影响因子
INDUSTRIAL & ENGINEERING CHEMISTRY RESEARCH
·
2019
·
IF 3.375
Xiao-Fan Lu,Wen-Hua Ji,Lin Yuan,Shui Yu,Dian-Shun Guo
A carboxy-functionalized covalent organic framework COOH@COF for efficient removal of Pb2+ and Hg2+ ions from water has been prepared. Fourier transform infrared spectroscopy, solid-state 13C NMR spectra, and elemental analysis indicate that the carboxy function has been grafted to COF materials via the click reaction. Its crystallinity remains unchanged after post-synthetic modification, as confirmed by the powder X-ray diffraction. Scanning electron microscopy images reveal that the COOH@COF possesses the thorn ball structure assembled by numerous nanowires with a diameter of 90 nm. This COOH@COF features excellent adsorption capacities for Pb2+ (123.8) and Hg2+ (99.1 mg/g) in water. The adsorption isotherms follow the Langmuir model, and their kinetics adsorption fits the pseudo-second-order model. Particularly, the COOH@COF can be recycled 20 times without loss of the adsorption capacity in water, showing its latent potential for practical application in the future.
研究领域:
环境科学
·
材料科学
·
水处理
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高影响因子
危险品化学品经营许可证（带存储）