EUROPEAN JOURNAL OF PHARMACEUTICS AND BIOPHARMACEUTICS
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2022
·
IF 5.589
Jianhua He,Xiaoju Zhou,Fengfei Xu,Hongliang He,Shuangyan Ma,Xinyue Liu,Mengyuan Zhang,Wenli Zhang,Jianping Liu
Macrophage/foam cells and cholesterol crystals (CCs) have been regarded as the central triggers of maladaptive inflammation in atherosclerotic plaque. Despite the tremendous progress of recombinant high-density lipoprotein (rHDL) serving for targeted drug delivery to alleviate inflammation in macrophage/foam cells, the active attempt to modulate/improve its CCs dissolution capacity remains poorly explored. The untreated CCs can seriously aggravate inflammation and threaten plaque stability. Based on the superb ability of β-cyclodextrin (β-CD) to bind CCs and promote cholesterol efflux, simvastatin-loaded discoidal-rHDL (ST-d-rHDL) anchored with β-CD (βCD-ST-d-rHDL) was constructed. We verified that βCD-ST-d-rHDL specifically bound and dissolved CCs extracellularly and intracellularly. Furthermore, anchoring β-CD onto the surface of ST-d-rHDL enhanced its cholesterol removal ability in RAW 264.7 cell-derived foam cells characterized by accelerated cholesterol efflux, reduced intracellular lipid deposition, and improved cell membrane fluidity/permeability. Finally, βCD-ST-d-rHDL exerted efficient drug delivery and effective anti-inflammatory effects in macrophage/foam cells. Collectively, anchoring β-CD onto the surface of ST-d-rHDL for selective CCs dissolution, accelerated cholesterol efflux, and improved drug delivery represents an effective strategy to enhance anti-inflammatory effects for the therapy of atherosclerosis.
研究领域:
药理学
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心血管疾病
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药物递送系统
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炎症
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脂质学
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产品关联
DOI
PubMed
高影响因子
SEPARATION AND PURIFICATION TECHNOLOGY
·
2021
·
IF 7.312
Adeel Ahmed,Muhammad Usman,Bing Yu,Fengyuan Gao,Youqing Shen,Hailin Cong
The unintended leakage of endocrine-disrupting bisphenol A (BPA) from different industries into the aquatic environment has posed a severe threat to aquatic lives and human health. Herein, we explored a hydrothermal method to synthesize superparamagnetic β-cyclodextrin-cobalt ferrite (β-CD-CoFe 2 O 4 ) catalyst for the selective capturing and efficient degradation of BPA through heterogeneous activation of peroxymonosulfate (PMS). The as-prepared catalysts were systematically characterized through multi-techniques to explore the relationship between their catalytic performance and material properties. Results showed that, in β-CD-CoFe 2 O 4 /PMS system, the degradation rate of BPA reached 99.23% in 60 min with a rate constant of 0.0708 min −1 , approximately 16.09 times than CoFe 2 O 4 /PMS system (0.0044 min −1 ). Specifically, the large surface area and availability of more reactive sites of β-CD-CoFe 2 O 4 boosted the activation process of PMS compared to pristine CoFe 2 O 4 , thus enhancing the degradation of BPA. Meanwhile, the effect of different operational parameters and co-existing anions on BPA degradation were also investigated. The generation of free radicals ( S O 4 ∙ - , ∙ O H , O 2 ∙ - , a n d 1 O 2 ) in the β-CD-CoFe 2 O 4 /PMS system liable for reducing BPA was corroborated through electron paramagnetic resonance analysis and quenching experiments. The possible degradation pathways of BPA were proposed based on the identification of reaction intermediates formed during the mineralization process. In brief, the findings of this study suggested that β-CD-CoFe 2 O 4 is an efficient and environmentally friendly catalyst that facilitated the degradation of BPA through PMS activation. Moreover, the excellent magnetic separation, stability, and reusability of the β-CD-CoFe 2 O 4 catalyst make them promising candidates for their water purification applications.
研究领域:
环境科学
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材料科学
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化学工程
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DOI
高影响因子
JOURNAL OF THE SCIENCE OF FOOD AND AGRICULTURE
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2026
·
IF 4
Ying Wang,Yi-Tong Du,Wen-Bo Yan,Zi-Tao Jiang,Jin Tan
BACKGROUND Cherry tomatoes are prone to postharvest deterioration and spoilage at room temperature, whereas chemical preservatives pose safety and environmental risks. Clove essential oil (CEO) has excellent antibacterial activity but is limited by high volatility, poor water solubility and dosage sensitivity. Cyclodextrin metal-organic frameworks (β-CD-MOFs) can improve CEO stability, but their poor processability and aqueous dispersibility hinder fruit preservation applications. Chitosan (CS), a natural hydrogel with film-forming and antibacterial properties, offers an ideal matrix to address these limitations. RESULTS A CEO-loaded CS/β-CD-MOFs composite coating (CS-CEO/MOFs) was constructed and evaluated on cherry tomatoes stored at 25 °C via physicochemical analysis, electronic eye color detection and texture profile analysis (TPA). Compared with control, CS and high-concentration CEO-chitosan (CS-CEO-H) groups, high-concentration CS-CEO/MOFs (CS-CEO/MOFs-H) delayed spoilage. Principal component analysis of electronic eye data showed the recognition index (a parameter reflecting the distinguishability of color characteristics among groups) increased from −3 (day 0) to 97–98 (days 6–21), indicating distinct inter-group ripening rate differences. TPA results indicated CS-CEO/MOFs-H slowed hardness decline (effect positively correlated with hydrogel concentration) and maintained higher soluble sugar, vitamin C and titratable acid contents, as well as reduced weight loss, extending room-temperature shelf life to 21 days. CONCLUSION The CS-CEO/MOFs coating combined the gas barrier property of CS and the controlled release capability of β-CD-MOF, forming a synergistic fresh-keeping mechanism. As a safe, natural preservative, it provides a promising solution to reduce cherry tomato postharvest losses and lays a foundation for the development of plant-derived composite preservatives with controlled-release and gas barrier synergistic properties. © 2026 Society of Chemical Industry.
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DOI
高影响因子
JOURNAL OF DRUG DELIVERY SCIENCE AND TECHNOLOGY
·
2021
·
IF 3.981
Yutong Dai,Qingman Li,Shurong Zhang,Shan Shi,Yang Li,Xudong Zhao,Liping Zhou,Xin Wang,Yijian Zhu,Wei Li
Efficient accumulation and on-demand intracellular drug release in the desired site are a crucial issue in developing ideal drug delivery systems (DDSs). Glutathione (GSH)/pH dual-bioresponsive degradable Nanosponges were developed based on β-CD-appended hyper-cross-linked polymer by one-pot polymerization of acryloyl-6- ethylenediamine-6-deoxy-β-Cyclodextrin (β-CD-NH-ACy), acrylic acid (AA) and N , N -bis(acryloyl)- cystamine (BACy) as cross-linker to deliver doxorubcin (DOX) and investigated for GSH/pH triggered DOX release, in which the massive carboxyl and amino groups, and disulfide bonds were used as pH and GSH bioresponsive fragments, respectively. In the proposed DDSs, DOX was readily incorporated into the three dimensional networks of the Nanosponges either as inclusion complexes or as non-inclusion complexes, with a high drug loading capacity of 22.6%. In vitro release studies suggested that the Nanosponges exhibited GSH/pH triggered disintegration and drug release performance, in which DOX release was significantly accelerated in acidic (pH5.0) and cytosolic reduction (10 mM GSH) conditions, with ~77.0% of DOX release. The morphology changes of DOX@Nanosponges in releasing media (pH5.0, 10 mM GSH) were further studied by TEM . Confocal microscopy observation demonstrated that DOX was delivered and released into cytoplasm and nucleus of A549 cells in 7 h incubation with DOX@Nanosponges. MTT assays manifested that the Nanosponges exhibited low cytotoxicity up to a concentration of 1000 μg/mL and DOX@Nanosponges had high anti-tumor activity. These findings demonstrated that the dual-bioresponsive Nanosponges may function as a promising platform for targeted delivery and intracellular drug controlled release in tumor therapy.
研究领域:
药学
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生物医学工程
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癌症研究
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材料科学
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产品关联
DOI
高影响因子
ENVIRONMENTAL SCIENCE AND POLLUTION RESEARCH
·
2018
·Vol. 25
·期 22
·22244-22258
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IF 2.8
Yan Xuechao,Zhang Xiaoping,Li Qian
In this paper, an effective chitosan/beta-cyclodextrin/nanometer zinc oxide (CS/β-CD/Nano-ZnO) composite porous membrane was synthesized by sol-gel and polymer-assisted inverting method. Preparation conditions of CS/β-CD/Nano-ZnO were investigated by single-factor and Box-Behnken response surface methodology optimizing triethoxyvinylsilane (JH-V151), beta-cyclodextrin (β-CD), and nanometer zinc oxide (Nano-ZnO), and applied to study the adsorption characteristics of Cong red (CR) from aqueous solution using batch experiments. The optimum preparation conditions were determined that the volume fraction of JH-V151 alcohol solution was 11%, the ratio of β-CD to CS was 5.35, and the ratio of Nano-ZnO’s mass to solution’s volume was 0.36%. Different characterization methods including field-emission scanning electron microscopy, X-ray diffraction, Fourier transform infrared spectroscopy, UV-visible spectroscopy, and Universal Materials Tester were used to prove the appearance, crystallinity, functional groups, swelling degree, transmittance, and tensile property of CS/β-CD/Nano-ZnO. The optimized batch experimental parameters were 50 mg L −1 , 4 h, 7.0, 0.5 g L −1 , and 55.0 °C as initial concentration, contact time, pH, adsorbent dose, and temperature, respectively. The maximum adsorption capacity on CR reached 96.33 mg g −1 , which is 4.34 times with respect to CS. The batch experimental data were best described by a pseudo-second-order kinetics model and Langmuir isotherm model ( R 2 = 0.9965, theoretical saturated adsorption capacity 147.28 mg g −1 ). The values ∆G were − 2.09, − 4.73, and − 7.37 kJ mol −1 at 298, 308, and 318 K temperatures, respectively. The ∆H value was 76.68 kJ mol −1 , indicating the endothermic and spontaneous adsorption in nature. The ∆S value was 0.26 kJ mol −1 K −1 , a signal of entropy increase during adsorption. The adsorption capacity decreased only by 5.8% after six recycling runs, which indicated the reusability of CS/β-CD/Nano-ZnO. Therefore, the CS/β-CD/Nano-ZnO composite porous membrane is a promising membrane material for the efficient removal of CR from any water at large and economic scales at moderate concentration.
研究领域:
材料科学
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环境工程
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产品关联
DOI
PubMed
高影响因子
RSC Advances
·
2022
·Vol. 12
·期 28
·18004-18011
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IF 4.036
Lingling Xu,Chuan Zhou,Fan Wang,Huiqin Liu,Guangyuan Dong,Siyi Zhang,Tao Liu
In this study, a drug delivery system was prepared by grafting the targeting molecule arginine-glycine-aspartic acid (RGD) onto hyperbranched polyglycerol (HPG)-modified β-cyclodextrin (β-CD-HPG) for the targeted inhibition of nasopharyngeal carcinoma (NPC) cells. The obtained β-CD-HPG-RGD with a relatively small size and low surface charge delivered docetaxel (Doc) effectively and displayed a targeting effect to human NPC HNE-1 cells, as confirmed by confocal laser scanning microscopy and flow cytometry. The in vitro drug release analysis exhibited the controlled drug release kinetics of the β-CD-HPG-RGD/Doc nanomedicine. β-CD-HPG-RGD/Doc effectively inhibited the proliferation of HNE-1 cells and promoted apoptosis. Moreover, its biocompatibility in vitro and in vivo was assessed. The results indicate that the β-CD-HPG-RGD/Doc nanomedicine has potential application in NPC targeting therapy.
研究领域:
药剂学
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肿瘤学
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生物医学工程
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产品关联
DOI
PubMed
高影响因子
Journal of Materials Chemistry B
·
2017
·Vol. 5
·期 15
·2823-2831
·
IF 4.543
Dan Zhao,Xiaoqing Yi,Jiaqi Xu,Gongdao Yuan,Renxi Zhuo,Feng Li
Using the host–guest interaction between β-cyclodextrin (β-CD) and adamantane (Ad), and borate formation between phenylboronic acid (PBA) and cis-diols, a smart pH-responsible targeting drug delivery nanovehicle, PBA–PEG–CD/Ad-lys(Diol)–PCL, was prepared via one-step self-assembly. Under physiological conditions, the targeted PBA function could be restrained by binding PBA with diol components located at the interface of self-assemblies, and hydrophilic PEG segments could be shielded simultaneously. When the environmental pH decreased, the PBA groups could be unbound and exposed on the surface of self-assemblies, leading to recovery of its targeted function, as shown using fluorescence spectroscopy, in vitro cell toxicity, and uptake. Under acidic conditions, PBA–PEG–CD/Ad-lys(Diol)–PCL/Dox showed significantly increased uptake and toxicity toward HepG2 cells in comparison with the control group. The smart vehicles were further utilized to test their efficiency in overcoming drug resistance in chemotherapy. Compared with free Dox, PBA–PEG–CD/Ad-lys(Diol)–PCL delivered six times more Dox into MCF-7/ADR cells and showed greater toxicity toward the ADR cells. As a result, this may be a facile strategy toward constructing efficient targeting vehicles through the rational utilization of noncovalent interactions.
研究领域:
药剂学
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纳米技术
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药物递送系统
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癌症研究
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DOI
PubMed
高影响因子
ANALYTICA CHIMICA ACTA
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2022
·
IF 6.911
Ang Li,Song Xue,Yu Xu,Sihui Ding,Di Wen,Qi Zhang
A critical challenge in using deep eutectic solvents (DESs) in capillary electrophoresis (CE) is to develop separation systems in which a DES can really work as a single entity. To achieve this, the authors recently demonstrated a novel strategy that takes advantage of the aqueous dispersibility of hydrophobic DESs (or more accurately hydrophobic eutectic solvents (HESs)). However, the previous work was limited only to the separation of achiral analytes, e.g., analogues, homologues, and isomers. The present study was designed as a follow-up study in order to explore the feasibility of employing HES-type pseudo-stationary phases (PSPs) in CE for chiral separations . By using carboxymethyl-β-cyclodextrin (CM-β-CD) as a model chiral selector, we provide the first evidence that there is a potential synergistic effect between HESs and traditional chiral selectors. Specifically, the combined use of HES (−)-menthol:octanoic acid and CM-β-CD allowed excellent enantioseparations of several basic drugs which were not able to be resolved in the single CM-β-CD system. The enantioresolutions were significantly improved while the migration times of the enantiomers were also shortened due to the hydrophobic mechanism of the HES-type PSP. Critical factors influencing the novel chiral CE system were systematically investigated. Since HESs are considered as “designer” solvents with highly tunable properties, this study demonstrates the potential of employing HESs (or HDES)-type PSPs in CE for chiral separations .
研究领域:
分析化学
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色谱学
·
分离科学
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产品关联
DOI
PubMed
高影响因子
CHEMICAL ENGINEERING JOURNAL
·
2019
·
IF 8.355
Jie-Ping Fan,Jun-Jing Luo,Xue-Hong Zhang,Bing Zhen,Chun-Yi Dong,Yan-Chen Li,Jian Shen,Yu-Tong Cheng,Hui-Ping Chen
In this work, a novel electrospun β-cyclodextrin (β-CD)/chitosan (CS)/polyvinyl alcohol (PVA) nanofiber membrane was prepared to simultaneously and rapidly remove organic and heavy metal micropollutants. The preparation conditions were optimized by multi-objective response surface methodology, and obtained as follows: 100% of the amount of β-CD (relative to PVA), 49.49% of the amount of CS (relative to PVA), 20 cm of the distance between the needle tip and the collector drum, 0.23 mL h −1 of the flow rate of the spinning solution, and 8.72% of the amount of PVA (relative to water). The characterization by Fourier transform infrared spectroscopy (FTIR) and scanning electron microscopy (SEM) showed a well cross-linked β-CD/CS/PVA nanofiber membrane was formed. In the static and dynamic adsorption experiments, the results demonstrated that the β-CD/CS/PVA nanofiber membrane was highly efficient in simultaneous and rapid removal of organic and heavy metal micropollutants in water treatment process.
研究领域:
环境科学
·
材料科学
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产品关联
DOI
高影响因子
Journal of Water Process Engineering
·
2022
·
IF 7.34
Jun Zhang,Xi Quan,Fu Li,Chenxi Zhen,Linlin Yin,Wei Zuo,Yu Tian
Ferrate is increasingly used as an oxidant for chemical oxidation of pharmaceuticals and personal care products (PPCPs) in reclaimed water. However, the instability of ferrate in aqueous solution and its low content of active ingredients have limited its application in water purification . In this paper, a novel β-cyclodextrin encapsulated potassium ferrate composite (KFO@β-CD) is synthesized for the first time using a thermomelting-condensation method and used to degrade carbamazepine (CBZ). This study evaluates and demonstrates the superior stability, sustained release behavior and hygroscopic characteristics of KFO@β-CD. In-depth investigations show that KFO@β-CD with a mass ratio of 10:1 can degrade 85.2 % of CBZ in 60 min. Analyzing the transformation pathways of CBZ has shown that Fe(VI) performed more reactive with olefinic double bond owing to electron-rich organic moieties, which convert carbamazepine to oxidized products with low molecular weight . These results significantly improve the state of our knowledge about this highly efficient and stable oxidant, which is likely to be useful for further degradation of PPCPs.
研究领域:
环境科学
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化学工程
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水处理技术
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产品关联
DOI
高影响因子
JOURNAL OF MOLECULAR LIQUIDS
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2022
·
IF 6.633
Shaoping Ma,Fenfang Li,Zhijian Tan
Aqueous two-phase systems (ATPSs) have been used in the chiral resolution of various enantiomers in recent years. However, it is difficult to recycle and reuse the phase-forming components and chiral selectors in these applications. Therefore, a completely recyclable ATPS that is based on two temperature-responsive polymers, viz. , poly(MAH-β-CD-co-NIPAAm-DMAEMA-BMA) (P NDB-CD ) and poly(NVCL-AM) (P VAm ), was employed for the chiral separation of mandelic acid (MA) enantiomers. The two polymers can be recovered by simply adjusting the temperature; meanwhile, the polymer P NDB-CD can be used as a chiral selector. The factors that affect the chiral resolution process were also investigated. A maximum separation factor ( α ) of 1.49 was achieved via a one-step extraction under the following conditions: P VAm concentration of 14.0 wt%, P NDB-CD concentration of 9.0 wt%, MA concentration of 5.0 mg/g, and system pH of 4.0. Moreover, the two polymers can be easily recycled after the chiral separation process. The recyclable ATPS used for enantioseparation in the current study can provide new ideas for other applications by using enantioselective liquid–liquid extraction (ELLE).
研究领域:
化学
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材料科学
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分离科学
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产品关联
DOI
高影响因子
JOURNAL OF MOLECULAR LIQUIDS
·
2024
·
IF 5.3
Jianbin Zhang,Qiufang Bai,Mei Han,Xizhe Sun,Feixue Zhou,Xin Fang,Yuran Shi,Hongna Wang,Yaowen Zhang,Linwei Li,Linlin Fang
Herein, two highly stable β -CD and α-Alkenyl- β -CD ( α -Alk- β -CD) monolithic columns were fabricated by copolymerizing β -CD and α -Alk- β -CD with GMA onto the pretreated capillary by a simple one-pot strategy. 1 H NMR, SEM, FT-IR, TGA and BET surface area analyses were applied to characterize the prepared monolithic columns. The monoliths were evaluated on the enantioseparations of antibiotic drugs, antihistamine drugs, anticholinergic agents, antifungal drugs and pesticides. In contrast to the native β -CD monolith, the derived α -Alk- β -CD reveals significantly improved enantiodiscrimination performance for the analytes especially for pesticides. Through run-to-run (n = 6), day-to-day (n = 9), and column-to-column (n = 9) investigations, the RSDs values were all lower than 3.72 %. Molecular simulation reveled that the chiral recognition between α -Alk- β -CD and chiral drugs was an exothermic process mainly governed by interaction hydrogen bindings, resulting in different binding strength between a pair of isomers compounds and α -Alkenyl- β -CD, and then leading to different migration and finally achieving effective chiral separation.
研究领域:
分析化学
·
色谱学
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材料科学
·
药学
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产品关联
DOI
高影响因子
危险品化学品经营许可证（带存储）