INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
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2025
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IF 8.5
Yicheng Yang,Qinan Huang,Lipei Miao,Qihong Zhang,Chongyang Wu,Weike Su,Jingbo Yu
Crocetin (CT), a natural carotenoid dicarboxylic acid known for its high medicinal value, faces challenges such as poor water solubility, low bioavailability and instability, limiting its therapeutic applications. To overcome these challenges, this study introduces a novel Pickering emulsion gel stabilized by naturally sourced chitosan (CS) and γ -polyglutamic acid ( γ -PGA) nanoparticles (CS/ γ -PGA NPs) as a potential transdermal carrier for CT. The CS/ γ -PGA NPs were synthesized using an electrostatic crosslinking method pretreated by mechanical ball-milling, producing uniform and stable nanoparticles. These NPs stabilized a CT-loaded Pickering emulsion gel (CT-PE) with cornmint oil as the oil phase, achieving up to 98.53 % encapsulation efficiency. The CT-PE exhibited enhanced rheological properties, storage stability, sustained and targeted in vitro transdermal release, potent antioxidant activity, and effective antimicrobial effects with no cytotoxicity. Microstructural analysis revealed a dense network of aggregated particles forming a moderately strong gel structure, wherein encapsulated CT enhances emulsion stability through interaction with the gel network. The synergy between CS and γ -PGA facilitated a biocompatible and efficient carrier system, markedly boosting CT's therapeutic effectiveness. These results highlight CT-PE's potential as an effective transdermal carrier for CT, promising for future dermatological treatments and drug delivery systems.
研究领域:
药剂学
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材料科学
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生物医学工程
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DOI
PubMed
高影响因子
SCIENCE OF THE TOTAL ENVIRONMENT
·
2024
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IF 8.2
Kun Zhou,Deliang Yin,Chen Liu,Rongguo Sun
Farmland mercury (Hg) pollution poses a significant threat to human health, but there is a lack of highly efficient phytoextraction for its remediation at present. This study investigates the impact of poly-γ-glutamic acid (γ-PGA) on the phytoextraction capabilities of Pennisetum giganteum ( P. giganteum ) in Hg-contaminated soil. Our research indicates that amending γ-PGA to soil markedly enhances the assimilation of soil Hg by P. giganteum and transformation of Hg within itself, with observed increases in Hg concentrations in roots, stems, and leaves by 1.1, 4.3, and 18.9 times, respectively, compared to the control. This enhancement is attributed to that γ-PGA can facilitate the hydrophilic and bioavailable of soil Hg. Besides, γ-PGA can stimulate the abundance of Hg-resistance bacteria Proteobacteria in the rhizosphere of P. giganteum , thus increasing the mobility and uptake of soil Hg by P. giganteum roots. Moreover, the hydrophilic nature of Hg-γ-PGA complexes supports their transport via the apoplastic pathway , across the epidermis, and through the Casparian strip , eventually leading to immobilization in the mesophyll tissues. This study provides novel insights into the mechanisms of Hg phytoextraction, demonstrating that γ-PGA significantly enhances the effectiveness of P. giganteum in Hg uptake and translocation. The findings suggest a promising approach for the remediation of Hg-contaminated soil, offering a sustainable and efficient strategy for environmental management and health risk mitigation.
研究领域:
环境科学
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植物学
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DOI
PubMed
高影响因子
E-POLYMERS
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2019
·Vol. 19
·期 1
·323-329
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IF 1.491
XianRong Shen,DengZhou Xia,YiXin Xiang,JianGang Gao
In this paper, γ-valerolactone (GVL), a bio-based polar solvent, was applied as green solvent for iron(III)-catalyzed AGET ATRP without any external ligand. GVL is a fully degradable, non-toxic green solvent and has complex ability to iron halide complexes through –OCO- group. GVL as the solvent and the ligand for AGET ATRP of MMA in a controlled manner, as proved by kinetic study, the low PDI values and the increase in polymer molecular weight versus monomer conversion. Chain re-initiation experiments and 1 HNMR characterization were conducted to further confirm the living feature. Graphical
研究领域:
材料科学
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化学工程
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DOI
高影响因子
CHEMICAL ENGINEERING JOURNAL
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2019
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IF 8.355
Feifei Wang,Xiaolin Yu,Maofa Ge,Sujun Wu
A series of TiO 2 and γ-Fe 2 O 3 co-doped graphene oxide (GO) nanosheets ( x TiO 2 /γ-Fe 2 O 3 /GO) were prepared by a facile self-assembly method. The characterization results show that the x TiO 2 /γ-Fe 2 O 3 /GO have the advantages of narrow band gap energies (<2.47 eV), and high structure stability. The incorporation of TiO 2 into γ-Fe 2 O 3 /GO composite dramatically enhances the catalytic activity, and the 0.03TiO 2 /γ-Fe 2 O 3 /GO composite exhibits the highest catalytic efficiency (99%) for ciprofloxacin (CIP) degradation (10 mg/L, 50 ml) within 140 min under visible light, which is ~1.5 times higher than that of γ-Fe 2 O 3 /GO composite without TiO 2 . Furthermore, the photo-Fenton like mechanism was proposed by quenching experiment and electrochemistry method. The intermediates of the CIP degradation were analyzed by the assistance of LC-MS technology, which provides insight into the pathway of CIP degradation.
研究领域:
材料科学
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环境科学
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光催化技术
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产品关联
DOI
高影响因子
Frontiers in Chemistry
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2019
·
IF 3.782
Li Zhanyi,Liu Guoguang,Su Qing,Lv Chunyan,Jin Xiaoyu,Wen Xiaoqing
Naproxen (NPX) is one of the most common pharmaceutical and personal care products found in surface water, which is recalcitrant to degradation by biological treatment or complete removal via traditional sewage treatment processes. In this study, nanoscale γ-FeOOH was synthesized and characterized by X-ray diffraction, scanning electron microscopy, surface analysis, and analysis of the forbidden bandwidth. Under UV irradiation, γ-FeOOH had the capacity to rapidly photodegrade NPX. The photodegradation rate of NPX was dependent on the concentration of γ-FeOOH in solution, initial NPX concentration, and pH. By increasing the concentration of γ-FeOOH, the NPX photodegradation rate was increased and then remained stable. Furthermore, the highest photodegradation rate for NPX was observed under acidic conditions. Through the analysis of the active substances (such as h+, e−, OH, 1O2, and O2·-) by electron spin resonance, the photocatalytic mechanism of NPX degradation on γ-FeOOH was determined to be semiconductor photocatalysis.
研究领域:
环境科学
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药学
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产品关联
DOI
PubMed
高影响因子
ACS Applied Polymer Materials
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2025
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IF 4.7
Rui Jiang,Xihong Xu,Yingchun Lu,Dengchao Hu,Yongsheng Li,Yuanlin Zhou
Epoxy coatings with both self-cleaning and radiation protection functions have important application prospects in the nuclear industry. However, combining these two functions poses a significant challenge. To address this challenge, epoxy resin (EP) was modified with hydroxyl-terminated polydimethylsiloxane (PDMS) as the matrix. Additionally, 1H,1H,2H,2H-perfluorodecyltriethoxysilane hydrophobically modified micrometer-sized bismuth oxide (Bi2O3) was used as a functional filler. By adjusting the roughness with a small amount of hydrophobic silica (SiO2), a superhydrophobic self-cleaning coating with γ radiation shielding capabilities was successfully developed. The resulting coating demonstrated exceptional self-cleaning properties, mechanical stability, and remarkable γ-ray shielding in tests.
研究领域:
材料科学
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核工业应用
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化学工程
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产品关联
DOI
高影响因子
JOURNAL OF CONTROLLED RELEASE
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2021
·
IF 9.776
Qian Li,Yaxin Zhou,Weidong He,Xiaomeng Ren,Mengzhu Zhang,Yue Jiang,Zhaocai Zhou,Yuxia Luan
Interferon-γ (IFN-γ) plays contradictory roles in tumor immunology: (I) to activate positive host's immunity for eliminating tumor; (II) to induce negative adaptive immune resistance via up-regulating programmed death ligand-1 (PD-L1) expression for tumors to evade immune surveillance. The negative feedback loop between the IFN-γ recovery and the IFN-γ-induced PD-L1 up-regulation puts postoperative adjuvant chemotherapy into a dilemma. It is of great significance but challenging to manipulate the double-edge effects of IFN-γ against postoperative tumor progression. Herein, a platelet-engineered nanoplatform ( [email protected] NPs) capable of harmonizing janus-faced nature of IFN-γ was designed via uniquely co-assembling doxorubicin (Dox) and cyclin-dependent kinase 5 inhibitor roscovitine (Rosco) with platelet membrane fragment (PMF) as the particulate stabilizer . With [email protected] NPs navigated by PMF to residual tumor, the Dox-activated immune response recovered IFN-γ secretion for positive host's immunity, while the IFN-γ-induced negative adaptive immune resistance was potently overcome by Rosco via disabling PD-L1 expression without dependence of IFN-γ stimulation. The negative feedback loop between IFN-γ recovery and PD-L1 up-regulation was thus potently disrupted in postoperative adjuvant chemotherapy. Our [email protected] NPs not only harmonized janus-faced nature of IFN-γ to effectively regulate postoperative tumor progression, but also illustrated an innovative strategy for high-drug-loading biomimic nanoplatform.
研究领域:
肿瘤学
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免疫学
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纳米技术
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药学
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产品关联
DOI
PubMed
高影响因子
JOURNAL OF THE BRAZILIAN CHEMICAL SOCIETY
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2019
·Vol. 30
·期 2
·359-370
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IF 1.335
Zheng Zhi,Lei Tong,Wang Jun,Wei Yi,Liu Xuejun,Yu Fengwen,Ji Jianbing
In this paper, we report the catalytic cracking of soybean oil for biofuel over γ-Al2O3/CaO composite catalysts. The influence of catalysts, cracking temperature and weight hourly space velocity (WHSV) on the products distribution were investigated. The maximum yield (70.0 wt.%) of biofuel with low acid value (6.7 mg KOH g-1) and oxygen content (5.6%), as well as high calorific value (44.2 MJ kg-1) was achieved over 35 wt.% γ-Al2O3/CaO at 480 ºC and 3.72 h-1. The paper focused on the variation of biofuel composition and cracking pathway caused by γ-Al2O3/CaO composite catalysts via gas chromatography-mass spectrometry (GC-MS) and thermogravimetric (TG) analysis. Calcium oxide would react with fatty acid to yield calcium carboxylates at 300-350 ºC, which were subsequently decomposed into hydrocarbons (57.9 wt.%) and ketones (22.6 wt.%) at 415-510 ºC. As for 35 wt.% γ-Al2O3/CaO, the addition of γ-Al2O3 was beneficial to generate alkenes (38.2 wt.%), arenes (10.6 wt.%) and alcohols (12.3 wt.%) with ketones decreasing (16.5 wt.%) via γ-hydrogen transfer reaction and disproportination.
研究领域:
化学工程
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可再生能源
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催化材料
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产品关联
DOI
高影响因子
ACS Catalysis
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2016
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IF 9.307
Shanhui Zhu,Yanfeng Xue,Jing Guo,Youliang Cen,Jianguo Wang,Weibin Fan
The high-yield synthesis of the biofuel γ-valerolactone (GVL) is a challenging task, which currently stems from the depolymerization of cellulose to levulinic acid, followed by its hydrogenation. We have developed a novel integrated process for the production of GVL from hemicellulose without using liquid acids and external hydrogen. The hemicellulose feed underwent hydrolysis and consecutive dehydration to produce furfural over ZSM-5 catalyst. Subsequently, the formed furfural with 2-propanol performed tandem conversion to GVL over Au/ZrO2 catalyst combined with ZSM-5. This process gave a high yield of GVL under mild conditions: up to 61.5% based on hemicellulose. The outstanding performance was mainly ascribed to the strong interface interaction of Au with ZrO2 species, large amounts of medium-strength acid sites over ZSM-5, and efficient synergy between active metal and acid sites.
研究领域:
生物化学
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催化化学
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DOI
高影响因子
CHEMOSPHERE
·
2018
·
IF 4.427
Huiwang Dai,Shuying Xu,Jianxin Chen,Xiaozeng Miao,Jianxi Zhu
Oxalate enhanced mechanism of Fe 3 O 4 @γ-Fe 2 O 3 was developed to provide novel insight into catalytic process regulation of iron oxide catalysts in heterogeneous UV-Fenton system. And the iron oxide composite of Fe 3 O 4 @γ-Fe 2 O 3 was characterized by X-ray diffraction (XRD), X-ray photoelectron spectroscopy (XPS), fourier transform infrared (FTIR) spectroscopy and nitrogen adsorption-desorption isotherms. The results showed that large amount of iron could be leached from catalyst in the presence of oxalate, which promoted the homogeneous UV-Fenton reactions in solution. Orange II degradation could be significantly enhanced with the increase of the ratio of homogeneous UV-Fenton process to heterogeneous UV-Fenton process. The optimum concentration of oxalate determined by experiment was 0.5 mM in oxalate enhanced heterogeneous UV-Fenton system. On this condition, the pseudo-first-order rate constant value of Orange II degradation was 0.314 min −1 , which was 2.3 times as high as that in heterogeneous UV-Fenton system. The removal rates of color and TOC were 100% and 86.6% after 20 min and 120 min treatment, respectively. In addition, the iron ions in solution could be almost completely adsorbed back to the catalyst surface in later degradation stages of Orange II. During the recycle experiments, the results showed that the increase of pH in solution and the sorption of intermediates on the catalyst surface would hinder oxalate enhanced process and lead to a decrease of degradation rate of Orange II in oxalate enhanced heterogeneous UV-Fenton system.
研究领域:
环境科学
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催化化学
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DOI
高影响因子
Nanoscale
·
2017
·Vol. 9
·期 25
·8825-8833
·
IF 7.367
Zhen Hu,Cheng Wang,Feng Zhao,Xirong Xu,Shuhong Wang,Long Yu,Dayu Zhang,Yudong Huang
The wonderful chemical structures and characteristics of low-dimensional carbon materials have exciting applications in life sciences. In the present study, we developed a facile strategy to conjugate C60 with graphene via host–guest chemistry for targeted phototherapy. A versatile carrier based on folic acid-functionalized graphene (GO-FA) and comprising γ-cyclodextrin (γ-CD) at its surface was assembled via π–π interaction, creating hybrid structures with drug storage and tumor targeting properties. This γ-CD-modified graphene (GO-FA/Py-γ-CD) is capable of hosting pristine C60 molecules for the fabrication of a GO-FA/Py-γ-CD/C60 nanohybrid. The hybridization of GO-FA, γ-CD, and C60 hinders the aggregation of C60, promotes cellular uptake, enhances light absorption, and finally demonstrates enhanced phototherapy effects of GO-FA/Py-γ-CD/C60. Under Xe lamp irradiation (2 W cm−2) for 4 min, GO-FA/Py-γ-CD/C60 simultaneously causes heating and intracellular ROS production, which further significantly reduces the cell viability to 16.2% at low content of loading (30 μg mL−1). Moreover, it represents an excellent tumor killing efficiency, better than that of the other reported graphene/C60 nanohybrids; thus, this material is suitable for applications in phototherapy of cancer.
研究领域:
生物医学工程
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纳米医学
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肿瘤学
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产品关联
DOI
PubMed
高影响因子
JOURNAL OF MOLECULAR CATALYSIS A-CHEMICAL
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2014
·
IF 3.679
Yuming Cui,Na Liu,Yifen Xia,Jiangang Lv,Sujuan Zheng,Nianhua Xue,Luming Peng,Xuefeng Guo,Weiping Ding
1-Butene, abundant but inexpensive in industry, can be used to produce more valuable propene and ethene through the well-known metathesis reaction. In terms of catalyst system of molybdena, controlling the interaction between the molybdena and the support is quite crucial. A special support, i.e., well-shaped one-dimensional γ-Al 2 O 3 with uniform diameters of ∼10 nm and lengths of ∼100 nm, has been synthesized via oleylamine-assisted hydrothermal method. The molybdenum oxides are well controlled in sizes of moderate aggregation suitable for 1-butene metathesis with a fairly high rate of propene production (38.9 × 10 −9 mol m −2 s −1 , 30 mol% yield in a single pass) under mild conditions. The status of MoO x species in the catalyst has been investigated by solid state 29 Si MAS NMR, Raman, UV–vis, H 2 -TPR and NH 3 -TPD techniques. The catalyst, highly stable after twelve times of regeneration, is important for practical utilization for the metathesis reactions.
研究领域:
化学工程
·
材料科学
✓ 已验证
产品关联
DOI
高影响因子
危险品化学品经营许可证（带存储）