International Journal of Applied Mechanics
·
2024
·
IF 2.9
Hong Sang,Jianying Hu,Erasmo Carrera,Jianke Du
When in an alternating magnetic field, magneto-thermal sensitive hydrogels can absorb solvent molecules, causing the gel network to swell several times to its original size. By conducting experiments with magnetic PNIPAm hydrogels (M-PNIPAm), the parameters of the theoretical model for magneto-thermal sensitive hydrogels were experimentally determined. Subsequently, the mechanical behavior of M-PNIPAm hydrogel was studied through finite element analysis and tensile experiments. The numerical calculations based on the thermodynamic model with specific parameters showed consistency with experimental results. The comparison indicated that the proposed theory for magneto-thermal sensitive hydrogels can accurately predict the mechanical property of M-PNIPAm hydrogel, providing theoretical support for investigating large deformation of magneto-thermal sensitive hydrogels. Furthermore, we discovered that the variation of magnetic particle content significantly influence the mechanics properties of hydrogel. Our findings provide valuable insights for the research and application of magneto-thermal sensitive hydrogels.
研究领域:
材料科学
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高分子科学
·
机械工程
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生物医学工程
·
应用物理学
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DOI
高影响因子
CHEMICAL ENGINEERING JOURNAL
·
2025
·
IF 13.2
Yi Li,Xueting Xuan,Zhouyi Pan,Yu Li,Tuan Quang Do,V.H. Giang Phan,Hongxu Chen,Thavasyappan Thambi
Conductive double-network (DN) hydrogels are widely used as flexible sensors for human health monitoring and other applications. However, designing multifunctional hydrogels that adapt to diverse environmental conditions remains a challenge. This study introduces a DN hydrogel composed of polyacrylamide (PAM) and carboxymethyl cellulose (CMC), synthesized via a one-pot strategy in a glycerol-water binary solvent. In this system, PAM forms a rigid primary network, while CMC acts as a flexible secondary network through divalent chelation with Ca 2+ and hydrogen bonding with PAM, significantly enhancing mechanical properties. The hydrogel showed high flexibility, tensile strain (>1550 %), strong adhesion to pig skin (18.3 kPa), and fatigue resistance (800 % static tensile strain over 10 consecutive cycles), which is due to the dynamic hydrogen bonding between glycerol with PAM and CMC. The incorporation of glycerol imparts exceptional freeze and drying resistance, maintaining stability across a broad temperature range (−25 °C to 50 °C). Rheological analyses revealed that the incorporation of Laponite nanoclay into hydrogels significantly enhanced viscoelasticity, shear-thinning behavior, and printability, making the precursor highly suitable for extrusion-based 3D bioprinting, which is mainly due to the Laponite incorporation partially reduces covalent crosslinking between monomers due to steric effects, while simultaneously introducing physical crosslinking points that enhance the overall network stability. Notably, the electromagnetic shielding effectiveness of MXene-incorporated hydrogel reaches 46.3 dB (a 56.16 % improvement) at 5 mm thickness. As a result, the hydrogels exhibit excellent conductivity and strain-sensing performance, enabling reliable detection of both subtle muscle contractions and large joint movements, highlighting their potential for next-generation wearable biosensors and human–machine interfaces. Incorporation of low concentrations silver nanowires (0–600 ppm) enhanced the hydrogels' antibacterial activity, with inhibition zones ranging from 0.46 to 0.62 cm for E. coli and 0.60 to 0.79 cm for S. aureus , achieving up to 95 % and 92 % inhibition, respectively, and highlighting their potential for skin-contact wearable biomedical sensors. These properties make the DN hydrogel prepared in this study a promising candidate for wearable devices and smart sensors in extreme environments.
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高影响因子
Nature Communications
·
2024
·Vol. 15
·期 1
·1-14
·
IF 14.7
Yang Ming,Wang Lufang,Liu Wenliang,Li Wenlong,Huang Yewei,Jin Qiaofeng,Zhang Li,Jiang Yuanwen,Luo Zhiqiang
Electroceuticals, through the selective modulation of peripheral nerves near target organs, are promising for treating refractory diseases. However, the small sizes and the delicate nature of these nerves present challenges in simplifying the fixation and stabilizing the electrical-coupling interface for neural electrodes. Herein, we construct a robust neural interface for fine peripheral nerves using an injectable bio-adhesive hydrogel bioelectronics. By incorporating a multifunctional molecular regulator during network formation, we optimize the injectability and conductivity of the hydrogel through fine-tuning reaction kinetics and multi-scale interactions within the conductive network. Meanwhile, the mechanical and electrical stability of the hydrogel is achieved without compromising its injectability. Minimal tissue damage along with low and stable impedance of the injectable neural interface enables chronic vagus neuromodulation for myocardial infarction therapy in the male rat model. Our highly-stable, injectable, conductive hydrogel bioelectronics are readily available to target challenging anatomical locations, paving the way for future precision bioelectronic medicine.
研究领域:
生物医学工程
·
神经科学
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材料科学
·
治疗学
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产品关联
DOI
PubMed
高影响因子
ACS Applied Materials & Interfaces
·
2021
·
IF 9.229
Xiaoning Ren,Ming Yang,Taotao Yang,Chao Xu,Yongqin Ye,Xiongni Wu,Xing Zheng,Bin Wang,Ying Wan,Zhiqiang Luo
Conductive polymer hydrogels (CPHs) hold significant promise in broad applications, such as bioelectronics and energy devices. Hitherto, the development of a facile and scalable synthesis method for CPHs with high electrical conductivity and biocompatibility has still been a challenge. Herein, we demonstrate highly conductive PPy–PEDOT:PSS hybrid hydrogels which are prepared by a simple solution-mixing method. This fabrication method involves the mixing of a pyrrole monomer with a PEDOT:PSS dispersion, followed by in situ chemical oxidative polymerization to form polypyrrole (PPy). The electrostatic interaction between negatively charged PSS and positively charged conjugated PPy facilitates the formation of PPy–PEDOT:PSS hybrid hydrogels. The conductivity of the PPy–PEDOT:PSS hybrid hydrogels is 867 S m–1. The PPy–PEDOT:PSS hybrid hydrogels show excellent biocompatibility. Moreover, the PPy–PEDOT:PSS hybrid hydrogels have a hierarchical porous structure which facilitates the 3D cell culture within the hydrogels. The PPy–PEDOT:PSS hybrid hydrogels exhibit excellent in situ biomolecular detection and real-time cell proliferation monitoring performance, indicating their potential as highly sensitive electrochemical biosensors for bioelectronics applications. Our strategy for the fabrication of CPHs with the electrostatic interaction between the negatively charged conductive polymer and positively charged conductive polymer would provide new opportunities for the design of highly conductive conjugated hydrogels for bioelectronics applications and energy devices.
研究领域:
生物电子学
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材料科学
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生物医学工程
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产品关联
DOI
PubMed
高影响因子
ANALYTICAL AND BIOANALYTICAL CHEMISTRY
·
2016
·Vol. 408
·期 29
·8317-8323
·
IF 3.125
Yan Zequn,Xue Min,He Qian,Lu Wei,Meng Zihui,Yan Dan,Qiu Lili,Zhou Lijun,Yu Yingjie
A novel polymerized crystalline colloidal array (PCCA) sensing material for the detection of urine glucose was developed by embedding a two-dimensional (2-D) polystyrene crystalline colloidal array (CCA) in 3-acrylamidophenylboronic acid (3-APBA)-functionalized hydrogel. After adjusting the cross-linker concentration, this material showed significant sensitivity for glucose under lab conditions, the particle spacing of the PCCA changed from 917 to 824 nm (93 nm) within 3 min as the glucose concentration increased from 0 to 10 mM, and the structural color of the PCCA changed from red through orange, to green, and finally, to cyan. In further experiments, this material was used to semi-quantitatively detect glucose in 20 human urine (HU) samples. Compared with the traditional dry-chemistry method, which was applied widely in clinical diagnosis, the PCCA method was more accurate and cost-effective. Moreover, this method can efficiently avoid the errors induced by most of the urine-interfering elements like vitamin C and ketone body. With a homemade portable optical detector, this low-cost intelligent sensing material can provide a more convenient and efficient strategy for the urine glucose detection in clinical diagnosis and point-of-care monitoring.
研究领域:
生物医学工程
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材料科学
·
医学检测技术
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DOI
PubMed
高影响因子
Bioactive Materials
·
2022
·
IF 16.874
Yucong Li,Linlong Li,Ye Li,Lu Feng,Bin Wang,Ming Wang,Haixing Wang,Meiling Zhu,Yongkang Yang,Erik I. Waldorff,Nianli Zhang,Ingmar Viohl,Sien Lin,Liming Bian,Wayne Yuk-Wai Lee,Gang Li
Functional tissue engineering strategies provide innovative approach for the repair and regeneration of damaged cartilage. Hydrogel is widely used because it could provide rapid defect filling and proper structure support, and is biocompatible for cell aggregation and matrix deposition. Efforts have been made to seek suitable scaffolds for cartilage tissue engineering. Here Alg-DA/Ac-β-CD/gelatin hydrogel was designed with the features of physical and chemical multiple crosslinking and self-healing properties. Gelation time, swelling ratio, biodegradability and biocompatibility of the hydrogels were systematically characterized, and the injectable self-healing adhesive hydrogel were demonstrated to exhibit ideal properties for cartilage repair. Furthermore, the new hydrogel design introduces a pre-gel state before photo-crosslinking, where increased viscosity and decreased fluidity allow the gel to remain in a semi-solid condition. This granted multiple administration routes to the hydrogels, which brings hydrogels the ability to adapt to complex clinical situations. Pulsed electromagnetic fields (PEMF) have been recognized as a promising solution to various health problems owing to their noninvasive properties and therapeutic potentials. PEMF treatment offers a better clinical outcome with fewer, if any, side effects, and wildly used in musculoskeletal tissue repair. Thereby we propose PEMF as an effective biophysical stimulation to be 4th key element in cartilage tissue engineering. In this study, the as-prepared Alg-DA/Ac-β-CD/gelatin hydrogels were utilized in the rat osteochondral defect model, and the potential application of PEMF in cartilage tissue engineering were investigated. PEMF treatment were proven to enhance the quality of engineered chondrogenic constructs in vitro , and facilitate chondrogenesis and cartilage repair in vivo . All of the results suggested that with the injectable self-healing adhesive hydrogel and PEMF treatment, this newly proposed tissue engineering strategy revealed superior clinical potential for cartilage defect treatment.
研究领域:
生物医学工程
·
组织工程
·
再生医学
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产品关联
DOI
PubMed
高影响因子
Biomaterials Science
·
2020
·Vol. 9
·期 3
·882-891
·
IF 6.183
Zecong Xiao,Xinyao Zheng,Ying An,Kangning Wang,Junwen Zhang,Huacheng He,Jiang Wu
Growth factors (GFs) have been well known for their therapeutic effects on wound healing. Due to their vulnerable biostability, biomaterial carriers are usually used to deliver GFs to maintain their bioactivity. Among the carriers, PEG hydrogels are the most widely applied. But the uncontrolled release of GFs and their immunogenicity dramatically retard the application of PEG hydrogels as carriers of GFs. Herein, FGF2 loaded zwitterionic sulfobetaine methacrylate (SBMA) hydrogels were developed, and it was revealed that these hydrogels were more effective in delivering FGF2 for wound healing than were PEG hydrogels. In vitro studies demonstrated that SBMA hydrogels could successfully prolong the release of FGF2, which effectively maintained the bioactivity of FGF2. Further in vivo investigation showed that SBMA hydrogels could efficiently accelerate wound regeneration by promoting granulation tissue formation, collagen deposition, cell proliferation and migration, reepithelialization and angiogenesis. All results validated that SBMA hydrogels were promising substituents of PEG hydrogels for delivering FGF2 for wound regeneration.
研究领域:
生物材料
·
组织工程
·
伤口愈合
·
药物递送系统
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产品关联
DOI
PubMed
高影响因子
CHEMICAL ENGINEERING SCIENCE
·
2025
·
IF 4.3
Jinghao Cao,Jiarui Liu,Wenxiang Wang,Liangjiu Bai,Hou Chen,Kai Wei,Lixia Yang
This study reports a frost-resilient nanocomposite hydrogel engineered for flexible electronics operating under cryogenic conditions. The hydrogel integrates a polyvinyl alcohol–guar gum (PVA-GG) dual-network matrix with cellulose nanocrystals (CNCs) grafted with glycosylated borate ammonium phytate (GBAP) and L-proline (L-Pro), forming hierarchical hybrid reinforcements through molecular interface engineering. Phytic acid (PA) enables multivalent coordination crosslinking, while L-Pro provides cryoprotection and maintains ductility at low temperatures. The resulting hydrogel exhibits excellent stability at −20 °C, including a tensile modulus of 2.11 MPa and 92.94 % self-healing efficiency. As a flexible sensor, it delivers a gauge factor of 2.72 and a rapid response time of 270 ms at −20 °C, enabling reliable monitoring of human motion. This work presents a scalable strategy for designing hydrogels with synergistic mechanical, self-healing, and anti-freezing capabilities, advancing flexible electronics for extreme-environment, wearable, and biomedical applications.
研究领域:
生物材料
·
高分子科学
·
柔性电子
·
生物医学工程
·
纳米复合材料
·
极端环境电子学
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产品关联
DOI
高影响因子
POLYMER
·
2019
·
IF 3.771
Feng Chen,Ziqing Tang,Shaoping Lu,Lin Zhu,Qilin Wang,Qin Gang,Jia Yang,Qiang Chen
Double network hydrogels (DN gels) are one of most extensively investigated high strength hydrogels. However, most of DN gels are concern to macromolecules , low-molecular-weight gelators (LMWG)-based supramolecular hydrogels are rarely reported to fabricate recoverable DN gels. Owing to the low mechanical properties, LMWG-based supramolecular hydrogels are hardly fabricated as conductive materials for human motion monitoring. Herein, we report a general strategy to fabricate strong, tough and conductive cholate-based supramolecular gels with double network (DN) structure (i.e. La-cholate/PAAm DN gels), consisting of La-cholate supramolecular gel as first network and covalent polyacrylamide gel (PAAm gel) as second network, in which La-cholate supramolecular gel was self-assembled by La 3+ ions and sodium cholate under sonication via the synergistic effect of hydrogen bonds , hydrophobic interactions and metal-coordination. At optimal condition, La-cholate/PAAm DN gel exhibited high tensile properties (fracture stress of 0.314 MPa, fracture strain of 29.85 mm/mm, elastic modulus of 90 kPa, and work of extension of 5.678 MJ/m 3 ) and high toughness (tearing energy of 1098 J/m 2 ), which are comparable to conventional chemical or hybrid DN gels. Meanwhile, La-cholate/PAAm DN gel also showed rapid self-recovery property (stiffness recovery of 84% and toughness recovery of 46% after resting for 3 min) at room temperature and λ-dependent luminescent property under UV-light. More importantly, cholate-based supramolecular gels with DN structure could be prepared with various metal ions and monomers . Interestingly, our cholate-based DN gels were ionically conductive, which could be used as strain sensor to finely detect the human motions. We hope our design principles, along with the simple method and cholate-based DN gels, can be generally applied to develop a new generation of strong and tough LMWG-based supramolecular hydrogels with various functionalities.
研究领域:
高分子科学
·
生物材料
·
软物质物理
·
纳米医学
·
组织工程
·
智能响应材料
·
生物传感
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DOI
高影响因子
Polymer Chemistry
·
2018
·Vol. 9
·期 29
·4063-4072
·
IF 4.927
Yan Chen,Yuting Gao,Lucília P. da Silva,Rogério P. Pirraco,Mengdi Ma,Liming Yang,Rui L. Reis,Jie Chen
The aim of this research was to develop thermo- and pH-responsive hydrogels based on H-bonds for the sustained release of the small-molecule model drug Methylene Blue (MB). The thermo- or pH-sensitive triblock copolymer based on PNIPAM or PAA was synthesized by sequential RAFT polymerization and hydrolysis. By tuning the temperature or pH, the copolymer was able to form diverse nanostructures, including core–shell micelles, electronegative or uncharged core–shell structures and 3D networks with the hydrophobic forces of PNIPAM or H-bonds between PAA and PNIPAM. Furthermore, the reversible sol–gel transition of the copolymers was modulated by temperature (∼37 °C), pH (∼5) and concentration (∼7 wt%). The drug release potential was evaluated via in vitro injection of copolymer hydrogels into a simulated human body device. The copolymer hydrogels exhibited a sustained drug release behavior and a low instantaneous drug concentration. The MTT studies revealed that there is no noticeable cytotoxicity of NDB or NDA hydrogels against cells. Thus, the tunable drug release efficiency suggests the possibility of PNIPAM- and PAA-based environment responsive hydrogels being applied as drug carrier systems.
研究领域:
材料科学
·
生物医学工程
·
药剂学
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DOI
高影响因子
Device
·
2025
·
IF 8
Han Wu,Jun Li,Hengwei Gong,Hui Liu,Wei Ou-Yang
Triboelectric nanogenerators (TENGs) typically use insulating polymers as the tribo-layer and different conductive materials as the electrodes. Conductive hydrogels (CHGs) can be used as both the electrode and tribo-layer and simplify the structure of a TENG. However, hydrogel dehydration may cause charge dissipation, impairing long-term performance. Here, we explore the relationship between electrical conductivity and the surface charge density of the TENG. We leverage the active rehydration behavior of hydrogels instead of conventional evaporation suppression to boost the triboelectric output. This is an alternative to existing material modification techniques. The created CHG-TENG achieves a surface charge density of 325 μC·m −2 and a sensitivity of 1,572 mV·kPa −1 . The high-output and electron-donating CHG with high responsivity has potential for applications in tactile sensor arrays.
研究领域:
生物医学工程
·
柔性电子
·
传感器技术
·
功能材料
·
可穿戴设备
·
组织工程
·
纳米能源
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产品关联
DOI
高影响因子
RSC Advances
·
2019
·Vol. 9
·期 4
·2081-2091
·
IF 3.049
Jiajia Shen,Miao Du,Ziliang Wu,Yihu Song,Qiang Zheng
Biological fouling, where marine microorganisms attach densely to various submerged surfaces, has been a serious economic problem worldwide. Different from most antifouling approaches based on stiff and solid materials or coatings, a soft and wet coating composed of zwitterionic polymer was prepared in this paper. With the combination of the anti-polyelectrolyte effect of poly-N-(3-sulfopropyl)-N-(methacryloxyethyl)-N,N-dimethylammonium betaine (PSBMA) and the typical polyelectrolyte effect of polyacrylic acid (PAA), a bicomponent hydrogel coating with weak swelling in saline solution was achieved, which could avoid peeling from solid substrates. The bicomponent hydrogel coating showed strong tensile properties and good compression performance and slipperiness. Although the large Young's modulus of the coating relatively weakens the drag reduction effect, entering the mixed lubrication region in low sliding rate is easy and a low friction coefficient at a high rate could thus be obtained. With the aid of silane coupling agent and weak deformation in water and saline solution, the hydrogel coating could be bound tightly on solid surfaces. After strong sandy water abrasion, the bicomponent hydrogel coating could maintain its original state without any cracks and peeling. The hydrogel coating exhibits good anti-bacterial adhesion and anti-protein adsorption. The bicomponent zwitterionic hydrogel coating reported here provides a new strategy for marine antifouling and drag reduction studies.
研究领域:
材料科学
·
海洋生物学
·
表面化学
·
高分子科学
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DOI
PubMed
高影响因子
危险品化学品经营许可证（带存储）