CHEMICAL ENGINEERING JOURNAL
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2026
·
IF 12.5
Jiaxin Zhou,Zitao Lin,Peng Yuan,Hongling Bu,Meiqing Chen,Honghai Wu,Yanfu Wei
The development of cost-effective catalysts for green diesel production from fatty acids is crucial to sustainable energy, yet achieving high efficiency under mild, low-H 2 pressure conditions remains challenging. Natural halloysite nanotubes (HNT), owing to their abundance, low cost, and high metal-loading capability, represent an attractive catalyst support. Herein, RuPt alloy nanoparticles supported on halloysite nanotubes are used for the efficient decarboxylation of stearic acid (SA). Under mild conditions using the in situ H 2 , the optimized Ru 0.7 Pt 1.0 /HNT catalyst exhibits high performance, achieving 87.40% SA conversion, with a C8-C19 alkane selectivity of 90.42%. Meanwhile, the catalyst maintains high catalytic activity over at least three consecutive reaction cycles. Combined experimental results and DFT calculations reveal that the RuPt bimetallic catalyst exhibits a significantly lower activation energy barrier than its monometallic counterparts. This reduction is attributed to electron transfer from Pt to Ru, which lowers the activation energy barrier and accounts for the superior performance. This work establishes a scalable low-noble-metal-loading catalyst design, offering an energy-efficient and sustainable route for green diesel production from waste cooking oils.
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NEW JOURNAL OF CHEMISTRY
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2026
·
IF 2.6
Yuzuo Liu,Jiawei Li,Bin Li,Zhigang Hu,Haoyu Lv,Ying Wang
In this work, nitrogen-doped carbon quantum dots (N-CQDs) were successfully synthesized via a microwave-assisted route using citric acid and o-phenylenediamine as precursors. A deep eutectic solvent was subsequently constructed using choline chloride as the hydrogen bond acceptor and glycerol/acrylamide as hydrogen bond donors. The N-CQDs were introduced as functional nanofillers, and a P(AM-Gly-ChCl)/N-CQDs composite hydrogel was obtained through photopolymerization. The chemical composition and microstructure of the composite hydrogel were systematically characterized by SEM, XPS, and FTIR, verifying the effective incorporation of N-CQDs into the hydrogel network. The effect of N-CQDs content on the mechanical, sensing, and adsorption properties of the hydrogel was elucidated. With increasing N-CQDs content, both tensile fracture stress and tear energy were substantially improved. The composite hydrogel exhibited an enhanced pressure-sensitive response, with a relative capacitance change of 137.0% achieved at an applied load of 1 N for the hydrogel containing 0.3 wt% N-CQDs. In addition, incorporation of N-CQDs endowed the hydrogel with effective Fe3+ adsorption capability and pronounced fluorescence quenching behavior, highlighting its potential for multifunctional applications that integrate pressure sensing and metal-ion detection.
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Pharmaceuticals
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2026
·Vol. 19
·期 3
·
IF 5.7
Qian Wang,Zhuohui He,Siyu Ji,Jie Zhao,Pengfei Gao,Yunchuan Yang,Lijuan Li,Hairong Zhao,Chenggui Zhang
Background:Periplaneta americanagrease (PAG), a lipid-rich fraction with documented wound-repair properties, remains challenging. This study aimed to develop a stable and patient-friendly film-forming agent (PAP) from PAG for topical wound management.Methods: The chemical profile of PAG was characterized with GC-MS. The formulation was optimized via single-factor and orthogonal experimental design. Comprehensive physicochemical characterization was performed. A vehicle control (film without PAG) was used to isolate PAG’s bioactive effects. In vitro, antioxidant (DPPH/ABTS assays) and antibacterial activity were evaluated. In vivo efficacy was assessed using a murine full-thickness wound model (mice, 150 µL applied 3 times daily for 10 days), with bFGF and Kangfuxin solution as positive controls. Histological analysis was conducted on healed tissue.Results: GC-MS revealed PAG’s complex composition, rich in sterols, terpenoids, and heterocyclic compounds. The optimized PAP formed a uniform, flexible film with suitable mechanical strength and shear-thinning rheology. PAP showed significant antioxidant activity and selective antibacterial activity againstStaphylococcus aureus. In the wound model, PAP treatment significantly accelerated wound closure, achieving a 98.2% healing rate by day 10, comparable to positive controls and significantly superior to the vehicle control. Histology demonstrated enhanced re-epithelialization, reduced inflammation, and improved collagen organization.Conclusions: PAP was successfully formulated into a multifunctional film-forming agent that addresses key barriers to healing—infection, oxidative stress, and tissue regeneration. The results demonstrate its potential as an innovative therapeutic strategy for wound care.
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Nature Communications
·
2026
·
IF 18.1
Mao Congyang,Jin Wanyu,Dou Limeng,Guo Tong,Huang Jin,Wang Yi,Liu Xiangmei,Wu Shuilin,Qiao Wei,Xiang Yiming,Zhu Yizhou,Wu Jun,Yeung Kelvin Wai Kwok
The pandemic-scale progression of type 2 diabetes mellitus (T2DM) necessitates innovative interventions targeting the pathogenic triad of insulin resistance, dysregulation of lipid metabolism, and gut microbiome dysbiosis. Here, we report a synthetically bioengineered probiotic consortium (REcN-F/Ca) developed through directed metabolic adaptations of Escherichia coli Nissle 1917 (EcN) under iterative hydrogen peroxide selection, subsequently functionalized with fructooligosaccharide-calcium carbonate composites. REcN-F/Ca exhibits enhanced reactive oxygen species tolerance through upregulated antioxidant enzymes and hydrogen sulfide-mediated redox balancing, alongside improved gastrointestinal survivability. In high-fat diet-induced obese male mice, REcN-F/Ca restores gut microbiota diversity, enriches butyrogenic taxa (Lachnospiraceae and Blautia ), and rescues short-chain fatty acids depletion. Transcriptomic profiling reveals PPAR signaling activation, driving lipid metabolism and suppressing adipose inflammation. These effects translate to systemic metabolic improvements with attenuated weight gain (−25.4%), restored glucose homeostasis, and reduced insulin resistance (HOMA-IR: −73.2%) in the obesity and T2DM murine model. Our findings establish REcN-F/Ca as a synthetically engineered probiotic that simultaneously corrects intestinal ecological perturbations and reverses host metabolic dysfunction, proposing a paradigm for metabolic syndrome management.
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Cell Reports Physical Science
·
2026
·Vol. 7
·期 2
·
IF 6.9
Yitong Liu,Yanan Zhou,Jiajia Wu,Peng Wang,Congyu Wang,Wenlong Ma,Shao’e Sun,Jianming Wang,Wenyong Jiang,Dun Zhang,Zhongli Sha
Droplet electricity generator (DEG)-powered DNA biosensors offer significant advantages in ultrasensitive and portable detection. However, the suboptimal power output of conventional DEGs has hindered the advancement of their sensing performance. To address this limitation, we engineered a core-shell-structured high-entropy sulfide (HES)-based filler to construct an optimized intermediate layer for the DEG (TiO 2 @HES/PVDF [THP]-DEG), achieving a remarkable output voltage of 625 V and dramatically improving the detection limit of the DEG biosensor. Specifically, the research developed a THP composite as the functional intermediate layer, where the advanced material design effectively mitigates particle aggregation and leakage current, thereby enhancing sensor performance and extending the DNA detection range to the femtomolar (fM) level. Furthermore, we established a mathematical model to precisely correlate electrical signals with DNA concentration. The THP-DEG biosensor demonstrated exceptional performance in detecting DNA from Alvinocarididae and sulfate-reducing bacteria, achieving ultrahigh sensitivity with detection limits of 0.987 and 0.927 fM, respectively.
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FOOD CHEMISTRY
·
2026
·
IF 10.4
Zihan Xu,Ziyi Guo,Shengran Yu,Xinyi Shen,Yanqing Cong,Tong Wei,Wenming Pei,Shi-Wen Lv
Herein, a novel porous S-CoO/C composite with spatial confinement effect is synthesized. Notably, doped sulfur can have the reaction with Co site of CoO and trigger the d-p orbital hybridization between 3p orbital of sulfur and 3d orbital of cobalt. The d-p orbital hybridization effect can not only increase the content of oxygen vacancy, but also drive the transformation of Co sites from low to high spin states. Benefitting from these changes, more unpaired electrons are generated in S-CoO/C. As a result, the S-CoO/C exhibits moderate oxidase-like property and excellent peroxidase-like activity. In view of the superb peroxidase-like activity of S-CoO/C, a colorimetric assay is proposed for detecting H 2 O 2 and hydroquinone using TMB as the substrate, and developed detection methods have great advantage being a low LOD, a high recovery and a broad linear range. Furthermore, established colorimetric assay displays excellent analysis performance even in real samples.
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MEASUREMENT
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2026
·
IF 6.1
Yi Li,Shunye Huang,Jianyang Zhang,Rongqi Zhang,Feng Xia,Xuqiang Wu,Like Li,Yong Zhao
Cholesterol is a vital biomolecule in the human body. Abnormal blood cholesterol levels may increase the risk of cardiovascular disease and Alzheimer’s disease. Therefore, there is an urgent need to develop a highly sensitive and rapid method of detecting cholesterol concentration in clinical settings. To meet this demand, we developed a reflective fiber-optic cholesterol sensor based on multimode and single-mode fibers (MMF-SMF). The probe uses AuNPs, synthesised using the sodium citrate reduction method, as a sensitising material, and cholesterol oxidase serves as the sensing membrane. This reflective optical fiber surface plasmon resonance (SPR) biosensor enables the detection of cholesterol concentration with high sensitivity. Experimental results demonstrated that Au film- AuNPs coupling enhances the refractive index sensitivity by 41.3 % to 2243.9 nm/RIU. Cholesterol detection sensitivity increases by 16.02 % to 0.210 nm/nM, and the linear detection range expands from 0–50 nM to 0–70 nM and the detection limit decreases to 4.586 nM. The sensor also exhibits excellent selectivity and stability, and can be used for the detection of cholesterol concentration in real serum samples, offering an efficient solution for developing portable biosensors.
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DESALINATION
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2026
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IF 9.9
Yan Pan,Yuxi Zhang,Wei Lan,Ruimao Hua,Linchao Zhou,Wenhai Zhang,Yuming Yu,Hong Meng
Low-pressure reverse osmosis (RO) is a key technology for energy-efficient desalination, but traditional RO membranes suffer from the bottlenecks of permeability-selectivity trade-off and the requirement for high-pressure operation. To address this issue, this study synthesized a novel triptycene-based acyl chloride monomer (PETC) and prepared a polyamide thin-film composite membrane via interfacial polymerization with polyethyleneimine (PEI). The rigid non-planar framework of triptycene increases the free volume of the polyamide network, and its high-density benzene rings construct hydrophobic microdomains, which synergistically promote water molecule transport while inhibiting hydrated ion permeation. The optimized PETC-PEI membrane exhibits excellent low-pressure desalination performance: the NaCl rejection rate reaches 96.7% and the pure water permeability is 4.7 LMH/bar, which is significantly superior to the control TMC-PEI membrane (rejection rate: 50.9%; permeability: 2.48 LMH/bar), and it also has good long-term stability. This study provides a new molecular design strategy for high-performance low-pressure RO membranes and opens up a new path for the next generation of low-energy desalination technologies.
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JOURNAL OF NANOBIOTECHNOLOGY
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2026
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IF 15
Ma Tianyu,Li Qiang,Chen Xingwu,Dong Jixiang,Jiang Yuqing,Li Shanshan
Bioactive peptides are promising candidates for hair regeneration, but their topical application is often limited by poor skin delivery and the need for frequent dosing. To overcome these challenges, we designed a palmitoylated peptide, Pal-MPAPO, and incorporated it into a hyaluronic acid-based hydrogel microneedle (MN) system for localized transdermal delivery. The fabricated MNs showed adequate mechanical strength for skin insertion and provided a time-dependent, prolonged release of Pal-MPAPO. In human dermal papilla cells (DPCs), Pal-MPAPO activated the Wnt/β-catenin pathway and increased intracellular cyclic adenosine monophosphate (cAMP) levels in a predominantly VPAC1-dependent manner. Additional VPAC2 validation did not reveal a significant contribution to cAMP signaling under the tested conditions. Functional interactions between Pal-MPAPO and VPAC1 were supported by molecular docking, molecular dynamics simulations, receptor knockdown, and fluorescence imaging. In a C57BL/6 mouse model, Pal-MPAPO-loaded MNs significantly promoted hair regrowth, achieving efficacy comparable to minoxidil but at a reduced application frequency. These findings identify Pal-MPAPO as a potential peptide candidate for hair regeneration and suggest that hydrogel MN-assisted delivery provides a localized peptide administration strategy. Graphical The alternative text for this image may have been generated using AI.
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ACS Nano
·
2026
·Vol. 20
·期 35
·24553-24565
·
IF 17.3
Liao Chenyu,Guan Bin,Zhu Hongjiang,Cai Jingxuan,Ye Xiangyi,Zhou Jianhua
Bacterial contamination in liquid products remains a
major challenge
for food safety and public health, yet conventional detection methods
generally rely on sampling-and-testing workflows that disrupt the
original state of sealed containers. This limitation makes it difficult
to perform nondestructive, item-level surveillance during transportation,
storage, and consumer use. Here, we report a container-integrated
plasmonic metasurface interface for camera-readable bacterial surveillance
in liquid environments. The metasurface interface can be conformally
integrated onto the inner surfaces of transparent containers through
a clean nanotransfer lithography process, enabling long-term monitoring
of contamination-related changes. Instead of relying on spectral interrogation,
bacterial attachment and proliferation processes are converted into
spatial transmission image patterns that can be directly acquired
using a camera or smartphone. This image-based readout enables in
situ monitoring of bacterial proliferation and quantitative detection
of Escherichia coli in closed liquid
systems. Furthermore, deep image-feature analysis enables label-free
grouping of E. coli , Staphylococcus aureus , and their mixed samples with
an accuracy of 95%. This work establishes a container-integrated metasurface
interface for sampling-free bacterial surveillance, offering a promising
route toward nondestructive microbial screening in beverage safety
and other closed liquid systems.
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INDUSTRIAL CROPS AND PRODUCTS
·
2026
·
IF 6.4
Yukun Zhou,Yaqi Ge,Huaqiao Liu,Yigang Huang,Xiaolong Tian,Chuansheng Wang,Huiguang Bian,Yao Xiao
An enhanced ternary DES was prepared by glycerol and gallic acid as dual HBDs. • Foaming expansion and microwave irradiation synergistically promoted the network. • The total crosslink density and mono/disulfide crosslink density were all increased. • The tensile strength was improved with a higher storage modulus under dynamic stress. In this paper, a hydrogen bond network-enhanced ternary deep eutectic solvent (CGG-DES) was prepared using bio-based glycerol and gallic acid as dual hydrogen bond donors. Under the synergistic effect of porous channel construction through foaming expansion of natural rubber latex and enhanced reverse dehydration of water from the interior to the surface by microwave irradiation, a raw rubber network composed of an entanglement network, a hydrogen bonding network, and a chemical network was affected, improving the overall performance of the raw rubber and composites. Meanwhile, fresh natural rubber latex (FNRL) and concentrated natural rubber latex (CNRL) with different contents of non-rubber components were selected for comparative experiments. FTIR demonstrated that CGG-DES possessed a strong hydrogen bonding network and generated physicochemical interactions with the protein protective layer of rubber particles. With the participation of an appropriate amount of CGG-DES, the network density of the constructed raw rubber network increased, the molecular chains became more flexible, the molecular weight increased, and the molecular weight distribution became broader. Furthermore, the total crosslink density and mono/disulfide crosslink density determined by the swelling method also increased, while the aging resistance, mechanical properties, and dynamic properties were improved. Compared with acid-coagulated rubber composites, the tensile strength of 0.5 CGG/FNR and 0.5 CGG/CNR composites increased 31% and 21%, respectively, with a higher storage modulus under dynamic stress. The research provides a new method for the green modification and efficient drying of natural rubber.
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Materials Today Communications
·
2026
·
IF 4.9
Fuwen Chen,Wei Yang,Jiong Zhao,Bin Liu,Weipeng Miao,Bozhi Li,Yafei Fan
The fabrication of high-performance SiC power devices imposes stringent requirements on low-damage and high-consistency wafer thinning processes. To address challenges associated with ultrafine abrasive dispersion and pore structure regulation in vitrified-bonded diamond grinding wheels, the present study proposed an ice-templating method to fabricate diamond grinding wheels with aligned porous structures. Effects of solid loading and glycerol content on microstructure, mechanical properties, and grinding performance of the wheels were systematically investigated. Results showed that glycerol regulated ice crystal morphology, transforming pore structure from lamellar to interconnected “bead-like” form while significantly enhancing flexural strength. Increasing solid loading reduced lamellar spacing and improved both density and strength. Grinding wheel prepared with solid loading of 60 wt% and 5 wt% glycerol exhibited excellent grinding performance on SiC wafers. It achieved surface roughness ( R a = 2.23 nm) significantly lower than that of conventionally cold-pressed wheel ( R a = 3.42 nm), while maintaining uniform surface free of obvious damage. Moreover, the subsurface damage layer thickness was reduced to 105.6 nm compared to 198.5 nm for the conventional wheel. The present study demonstrated that ice-templating method enabled simultaneous uniform dispersion of abrasives and controlled pore structure, thereby providing efficient tool solution for precision grinding of hard and brittle materials such as SiC.
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