MATERIALS & DESIGN
·
2026
·
IF 8.2
Linjun Yang,Xuhui Fan,Weicheng Pan,Yao Jin,Jianle Wang,You Wang,Han Wang,Zhijun Hu
Composition-engineered Cu-doped ZIF-8 was designed for OA therapy. • Cu@ZIF-8 reduced oxidative stress and lipid peroxidation in chondrocytes. • Cu@ZIF-8 suppressed ferroptosis and preserved ECM homeostasis. • Intra-articular Cu@ZIF-8 attenuated OA progression in rats. Engineering metal–organic framework (MOF)-based materials with tunable composition and biological function offers a promising strategy for regulating pathological oxidative microenvironments. Herein, a composition-engineered copper-doped zeolitic imidazolate framework-8 nanoplatform, Cu@ZIF-8, was designed to modulate oxidative stress-associated lipid peroxidation and chondrocyte ferroptosis for osteoarthritis (OA) therapy. The incorporation of copper into the ZIF-8 framework enabled homogeneous elemental distribution while preserving the crystalline structure and high specific surface area of the MOF platform. In H 2 O 2 - and RSL3-induced chondrocyte injury models, Cu@ZIF-8 reduced intracellular ROS accumulation, alleviated lipid peroxidation, preserved mitochondrial membrane potential, restored GPX4/SLC7A11 expression, and maintained extracellular matrix homeostasis. Mechanistic studies suggested that Cu@ZIF-8-mediated ferroptosis suppression was associated, at least in part, with modulation of p38 MAPK/AKT signaling. In a surgically induced rat OA model, intra-articular administration of Cu@ZIF-8 attenuated cartilage degeneration, reduced oxidative and ferroptosis-related damage, and showed no apparent systemic toxicity under the tested conditions. This study establishes a composition-engineered MOF nanoplatform that links copper-doped ZIF-8 design with oxidative stress regulation, ferroptosis suppression, and cartilage protection, providing a materials-design strategy for OA microenvironment modulation. Download: Download high-res image (110KB) Download: Download full-size image
✓ 已验证
产品关联
DOI
高影响因子
PROCESS SAFETY AND ENVIRONMENTAL PROTECTION
·
2026
·
IF 7.9
Fangchong Han,Bin Zhang,Jie Liu,Lijun Niu,Jun Ke
In this work, a carbon and cobalt co-doped carbon nitride (Co 0.04 -CCN 0.25 ) catalyst was synthesized for superior generation of singlet oxygen ( 1 O 2 ) via peroxymonosulfate (PMS) activation. The findings indicate that carbon self-doping not only reduces the interfacial charge transfer resistance but also constructs efficient electron transfer channels between g-C 3 N 4 support and cobalt active sites. This directional electron transfer increases the electron density of cobalt species, which can accelerate the Co(II)/Co(III) redox cycle. As a result, the optimized Co 0.04 -CCN 0.25 catalyst achieves 100% of bisphenol A (BPA) degradation within 6 min under ambient conditions. Mechanistic investigations reveal that the singlet oxygen is the dominant reactive oxygen species (ROS) at the Co active site in the Co 0.04 -CCN 0.25 , which presents a desirable and recyclable redox pair of Co(II)/Co(III). Furthermore, the modified catalyst exhibits excellent pH tolerance over a broad range and strong anti-interference ability against co-existing anions and humic acid in aqueous solutions. Liquid chromatography-mass spectrometry (LC-MS) analysis and ecotoxicity assessment further demonstrate that the toxicities of BPA degradation intermediates are significantly reduced during the oxidation process. Therefore, this study provides a promising and practical strategy for designing high-efficient C 3 N 4 -based catalyst of PMS activation. Download: Download high-res image (175KB) Download: Download full-size image
✓ 已验证
产品关联
DOI
高影响因子
CHEMICAL ENGINEERING JOURNAL
·
2026
·
IF 12.5
Zening Pan,Yudie Fu,Jiayu Wu,Aihua Xu,Xiuying Liu,Shuaiqi Zhao,Xiaoxia Li
Vacancy electronic quality, not quantity, governs catalytic performance. • Co-doping and quenching construct asymmetric Co–Ov–Mo motifs, transforming inert deep traps into active shallow donors. • CMO-Q activates PMS through a dual non-radical pathway. The electronic structure characteristics of oxygen vacancies (O v ) - rather than their quantity - are the fundamental factors determining peroxymonosulfate (PMS) activation. This study proposes a strategy of cobalt doping and controllable quenching to precisely construct two types of O v configurations with distinct electronic properties in MoO 3 : the symmetrical Mo–O v –Mo coordination structure in MoO 3 -Q and the asymmetrical Co–O v –Mo coordination structure in CMO-Q. Comprehensive multimodal characterizations confirm that although MoO 3 -Q has the highest O v concentration (39.78%) and the strongest EPR signal, the significantly broadened tail feature in its valence band XPS spectrum clearly indicates that the vacancies exist in the form of deep-level trap states, making it difficult for the captured charges to participate in subsequent interfacial reactions, thus presenting electronic inertness. In contrast, cobalt doping plays a directional anchoring role in the lattice, guiding the vacancies to preferentially form in the Co-adjacent coordination environment. The constructed asymmetrical Co–O v –Mo structure induces an internal polarization electric field due to the difference in electronegativity between Co 2+ and Mo 6+ , forming a shallow donor state with electron-donating function, thereby endowing the vacancies with intrinsic electronic activity. The electrochemical tests quantitatively reveal the essential differences in interfacial charge transfer kinetics between the two: CMO-Q exhibits the largest open-circuit potential shift (0.59 V ) and the smallest peak potential difference (ΔE = 0.13 V ), while MoO 3 -Q shows the smallest shift (0.47 V ) and the largest ΔE (0.26 V ). Further normalization by the electrochemically active surface area (ECSA) highlights the intrinsic activity difference: the k obs /C dl of CMO-Q reaches 6.18 min −1 ·cm 2 ·mF −1 , which is ten times higher than that of MoO 3 -Q (0.62 min −1 ·cm 2 ·mF −1 ). This work establishes vacancy quality over quantity as the design principle for high-performance catalysts.
✓ 已验证
产品关联
DOI
高影响因子
FOOD CHEMISTRY
·
2026
·
IF 10.4
Long Bai,Xiuxiu Wu,Lei Huang,Haohao Chen,Jinsong Yu,Ziqing Ye,Min Yuan,Hui Cao,Liling Hao,Fengqin Yin,Tai Ye,Fei Xu
Hydrogel confinement modulates aptamer conformation for target recognition. • Three-site modified aptamer hydrogel shown 3.1-fold higher affinity than the free aptamer. • Aptamer confinement improved anti-interference under harsh conditions. • Label-free sensing of Pb 2+ and Cd 2+ was achieved in aptamer-confined hydrogels. Aptamer misfolding induced by complex sample matrices often compromises target recognition. Herein, we developed a hydrogel-confinement strategy to stabilize aptamer conformation and effectively suppress matrix interference. Using Pb 2+ as a model analyte, aptamers were immobilized during in situ hydrogel polymerization, which helped maintain key binding-related structural features and promoted a G-quadruplex-like pre-organized conformation favorable for target recognition. The confined aptamer acted as a Tb 3+ fluorescence sensitizer, enabling label-free Pb 2+ detection with an apparent K d of 0.25 μM and an LOD of 0.4 nM. The optimized aptamer hydrogel, featuring moderate interfacial cationicity and a three-site modified aptamer hydrogel showed 3.1-fold higher affinity than the free aptamer. It maintained stable responses under pH 3, salt concentrations up to 0.5 M, methanol content up to 30%, and nuclease exposure (0.16 U/mL). This strategy was further validated for Cd 2+ sensing, demonstrating its potential for aptamer-based detection in complex food and environmental matrices
✓ 已验证
产品关联
DOI
高影响因子
SENSORS AND ACTUATORS B-CHEMICAL
·
2026
·
IF 8.3
Xudong Liang,Yuchen Duan,Xiangyu Li,Fujia Zhao,Yunwei Li,Yiming Jian,Lei Shi,Jiayu Li,Guo-Dong Li
Detection of 3-hydroxy-2-butanone (acetoin), a characteristic volatile metabolite of Listeria monocytogenes (LM) , represents a promising non-invasive strategy for monitoring contamination levels of foodborne pathogens in food. However, current sensing materials suffer from poor selectivity and insufficient sensitivity at trace concentrations. Herein, a series of Pd-loaded Cd 2 GeO 4 (Pd/CGO) chemiresistive gas sensors that achieves highly selective and sensitive acetoin detection was reported. Among them, the 0.5 wt% Pd/CGO-based sensor exhibits a high response, with an ultrafast response time and a detection limit as low as 10 ppb. The sensor also demonstrates excellent selectivity over common interfering gases, good reproducibility, and robust long-term stability. Mechanistic investigations combining O 2 -TPD, XPS, and DFT calculations reveal that Pd loading not only increases the proportion of chemisorbed oxygen species on the CGO surface, which enhances the overall sensing response, but also serves as new active sites. This work demonstrates that rational Pd modification combined with dual-site engineering offers a promising paradigm for designing high-performance metal oxide gas sensors for pathogen biomarker detection in food.
✓ 已验证
产品关联
DOI
高影响因子
CHEMICAL ENGINEERING JOURNAL
·
2026
·
IF 12.5
Yu Liu,Changting Chen,Chengzuo Liu,Jianan Zeng,Jianqiang Luo,Xiaolan Tong,Xuejiao Peng,Shujuan Liu,Jianguo Ma
Constructed a type-II CoNC@CdS heterojunction for PEC reduction of U(VI). • PEC reaction rate was 12.8 times that of photocatalysis alone. • Built-in electric field and bias synergistically promoted charge separation. • Soluble U(VI) was efficiently converted to insoluble UO 2 precipitate. Photoelectrocatalytic (PEC) reduction of U(VI) is an effective strategy for treating uranium contamination in water. Herein, a CoNC@CdS type-II heterojunction electrode was designed for the efficient reduction of U(VI) via a PEC process. Under optimized conditions, the fabricated electrode delivers an outstanding U(VI) removal efficiency of 97.8%, accompanied by a pseudo-first-order kinetic rate constant of 0.0349 min −1 . The PEC reaction rate of CoNC@CdS is 20.1 and 12.8 times higher than that of single electrocatalysis and photocatalysis systems, respectively. Stability evaluation reveals that even after six successive cyclic tests, the U(VI) removal efficiency remains above 80%, demonstrating robust cycling durability. Mechanism characterizations elucidate that CoNC improves electrode conductivity and light absorption capability, while layered CdS shortens charge migration distance and restrains carrier recombination. The built-in electric field of type-II heterojunction combined with external bias drives spatial separation and directional transport of photogenerated charge carriers, thereby efficiently converting soluble U(VI) into insoluble UO 2 precipitates. This work provides a promising strategy for uranium recovery and remediation in complex aqueous matrices.
✓ 已验证
产品关联
DOI
高影响因子
Communications Earth & Environment
·
2026
·
IF 9.3
Yang Ning,Wang Xiaofei,Wang Junfeng,Deng Junjun,Wei Zhenwei,Fu Pingqing
The high electric field at the microdroplet interface plays a crucial role in regulating aqueous aerosol chemistry. However, the impact of charge at the air-water interface on sulfur-containing aerosols remains unclear. Here we show, using various microdroplet systems, how interfacial reactions of sulfur-containing aerosols proceed under different charge conditions. Field observations were also conducted across multiple regions to characterize the molecular composition of aqueous sulfur-containing aerosols. In small negatively charged droplets, sulfite is spontaneously oxidized to sulfate, with an estimated rate comparable to reported rates of sulfite oxidation by common atmospheric oxidants. Meanwhile, sulfur radicals like sulfate radicals are generated, leading to the rapid formation of organosulfates. In large positively charged droplets, sulfate is spontaneously reduced to sulfite radicals and sulfite, promoting the formation of organosulfonates. These results provide key insights into how charge at the air–water interface affects sulfur aerosols and contribute to our understanding of air pollution.
✓ 已验证
产品关联
DOI
高影响因子
Nature Communications
·
2026
·
IF 18.1
Zuo Shulin,Lin Muke,Xu Guizhi,Huang Jiahao,Zhang Rumeng,Mei Ji,Fang Jingyun,Xia Dehua
Conventional catalytic ozonation of electron-rich sulfur-containing pollutants shows limited efficiency due to nonselective oxidation of hydroxyl radicals ( • OH) and sulfate-induced deactivation of active metal sites. Here, we synthesized a high-entropy spinel, (CuNiMnCo)Fe 2 O 4 , featuring sublattice-resolved electronic reconstruction that enables selective ozone activation and suppresses sulfur poisoning. The catalyst achieves 99% removal of methyl mercaptan (CH 3 SH), significantly outperforming 51% of CoFe 2 O 4 . Spectroscopic analyses and density functional theory calculations reveal that high-entropy doping induces lattice distortion and local coordination disorder, which strengthen A–O–B covalency and inter-site electronic communication. This structural perturbation further drives a sublattice-resolved electronic reconstruction, enriching Co/Mn sites while depleting Fe/Cu/Ni sites. This electronic differentiation promotes cooperative dual-end activation of O 3 on Fe–Co/Mn motifs and preferential CH 3 SH adsorption on Cu/Ni sites. Orbital modulation of Co t 2g and Fe e g states near the Fermi level balances interfacial charge transfer, favoring formation of a surface-bound *O 3 species over conventional O–O bond cleavage. The resulting spatially separated activation and oxidation sites enable CH 3 SH mineralization via an electron transfer process while suppressing • OH generation and minimizing sulfate accumulation. This spatially differentiated reaction environment ensures durable performance under humid conditions. These findings establish sublattice-engineered electronic asymmetry as a strategy for selective catalytic ozonation.
✓ 已验证
产品关联
DOI
高影响因子
Nature Communications
·
2026
·
IF 18.1
Liu Xu,Cao Miao,Jia Feiyue,Jia Hongbao,Li Zonglin,Guo Xueping,Zhang Junrong,Hua Weijie,Li Lina,Wu Qian,Zhao Hongying
Antibiotic-resistant bacteria (ARB) and their genes (ARGs) pose a significant risk to public health and the ecosystem. Conventional water disinfection efficiently eliminates pathogens, however, it requires intensive chemical consumption but inefficiently removes ARGs. Herein, we propose an on-demand electrochemical platform that simultaneously eliminate both ARB and ARGs with in-situ generated hydroxyl radicals (·OH) without additional chemical inputs. Single-atom copper catalysts with CuN 4 coordination structure (SA-CuN 4 /NC) are precisely tuned to directly convert oxygen into controllable ·OH via three-electron oxygen reduction reaction (3e⁻ ORR). Operando X-ray adsorption near-edge spectroscopy reveals a potential-driven self-reconstruction of single-atom Cu sites to optimize ·OH concentration. Specially, the preferentially adsorbed H + onto the adjacent N atoms promotes the breaking of Cu-N bonds to form stable Cu 2 -CuN 2 cluster as a genuine active site. As expected, the SA-CuN 4 /NC with moderate ·OH (~11.5 μM) exhibits ultra-fast degradation of E. coli HT115 , accomplishing an ~ 8 log removal within 1 min and a complete elimination of ARGs in 30 min. Excess ·OH (~47.9 μM) triggers bacterial aggregation which compromises bacterial inactivation. These findings demonstrate that 3e⁻ ORR is a sustainable and effective strategy to obtain fast and complete water disinfection, preventing environmental spread of ARGs.
✓ 已验证
产品关联
DOI
高影响因子
ANALYTICAL AND BIOANALYTICAL CHEMISTRY
·
2026
·
IF 4.1
Xue Jun-Chang,Jiang Yue,Xia Huan,Hou Lu,Li Heng-Ye,Wang Zhong-Xia,Kong Fen-Ying,Wang Wei
An electrochemical sensor was developed for the sensitive voltammetric determination of 4-nitrophenol (4-NP) by integrating an in situ grown nanocomposite of amino-functionalized carbon nanotubes (NH 2 -CNTs) and a zinc porphyrin-tetrathiafulvalene covalent organic framework (TTCOF-Zn). This hybrid design strategically couples the electron donor–acceptor (D-A) architecture of TTCOF-Zn, featuring pre-engineered electron transport channels, with the exceptional electrical conductivity of NH 2 -CNTs via covalent bonding, synergistically enhancing charge transfer efficiency. Leveraging the high conductivity, abundant active sites, and hierarchical porosity of the TTCOF-Zn/NH 2 -CNTs nanocomposite, the modified electrode achieves an exceptional detection limit of 17 nM (linear range, 50 nM–1 mM) using differential pulse voltammetry, surpassing most reported sensors. The sensor also demonstrates excellent reproducibility, long-term stability, and strong anti-interference capability against common co-existing species. Its practical applicability was demonstrated through quantitative analysis of 4-NP in real lake water samples, with results validated by the HPLC method, underscoring the potential of D-A COF/CNT covalent hybrids for high-performance environmental monitoring. Graphic
✓ 已验证
产品关联
DOI
高影响因子
JOURNAL OF MATERIALS SCIENCE-MATERIALS IN ELECTRONICS
·
2026
·Vol. 37
·期 22
·1766
·
IF 3.2
Wang Dingqin,Fei Zihao,Zheng Deyi
Perovskite-structured Li 0.33 La 0.56 TiO 3 (LLTO) ceramic fillers are widely used for their low cost and environmental friendliness, yet their poor uniform dispersion in polymer matrices and inadequate interfacial compatibility between phases still limit performance. This study fabricated PDA@LLTO/PVDF-HFP composite electrolytes via solution casting, by modifying LLTO with a biodegradable polydopamine (PDA) coating. Dopamine undergoes oxidative self-polymerization on LLTO surfaces to form a PDA layer, whose excellent adhesion ensures firm binding to the LLTO surfaces, reducing filler surface energy and promoting uniform dispersion. Meanwhile, PDA’s phenolic hydroxyl and amino groups interact with PVDF-HFP’s fluorine and carbonyl groups via hydrogen bonding, electrostatic interactions, and physical entanglement, forming a strong interface. PDA reduces interfacial gaps and defects by acting as a “molecular bridge” to improve adhesion between the two phases. Results show the 2.4 wt%-PDA@LLTO/PVDF-HFP composite exhibits well-balanced electrochemical performance: an ionic conductivity of 2.37 × 10 −4 S cm −1 at 25 °C, an interfacial impedance reduced from 367 to 167 Ω, a lithium-ion migration number of 0.81, and an electrochemical stability window expanded to 4.88 V, The critical current density reaches 2.297 mA/cm 2 . The assembled solid-state full batteries deliver an initial discharge capacity of 168.59 mAh/g at 0.5 C, retaining 148.80 mAh/g (88.3% capacity retention) after 180 cycles, with Coulombic efficiency stabilized at 99.6% and significantly improved thermal stability. This work provides new insights for developing high-performance all-solid-state electrolytes, which hold promising applications.
✓ 已验证
产品关联
DOI
高影响因子
ANALYTICAL AND BIOANALYTICAL CHEMISTRY
·
2026
·
IF 4.1
Wei Ruxia,Sheng Wei,Chen Shengyu,Zheng Yiwei,Li Xu,Feng Na,Luo Yanni,Tan Xuecai,Huang Ke-Jing
The development of highly sensitive and selective platforms for trace Zn 2+ detection is crucial for environmental monitoring and biomedical diagnostics. Herein, a photoelectrochemical (PEC) sensor was constructed using an L-cysteine (L-Cys)-functionalized BiOBr composite, in which surface-interface engineering was adopted to enrich available recognition sites and modulate the interfacial PEC response. Compared with pristine BiOBr, the incorporation of L-Cys introduces abundant Zn 2+ binding functional groups and modifies the local surface environment of BiOBr, thereby enhancing the photocurrent response and enabling the selective recognition of Zn 2+ . The sensor operates through a signal-off mechanism, in which the coordination of Zn 2+ with surface-bound L-Cys forms an interfacial coordination layer that partially hinders mass transport and interfacial charge transfer, resulting in a decrease in photocurrent. Under optimized conditions, the platform exhibits a wide linear response ranging from 0.5 to 40 nmol/L, with a low detection limit of 2.69 nmol/L ( S / N = 3). Furthermore, the applicability of the sensor is validated in real-world scenarios, demonstrating excellent recoveries in tap water, lake water, and complex biological matrices such as HepG2 cell lysates (recoveries, 96.3–108.5%). This work provides a robust strategy for engineering bio-semiconductor interfaces for the detection of essential metal ions in complicated samples.
✓ 已验证
产品关联
DOI
高影响因子
危险品化学品经营许可证（带存储）