MICROCHIMICA ACTA
·
2015
·Vol. 182
·期 7
·1337-1344
·
IF 3.741
Cui Yang,Liu Sheng,Wei Kaiju,Liu Yangzhong,Hu Zhangjun
We describe a method for magnetic solid phase extraction of trace-levels of Hg(II) ions by using Fe 3 O 4 nanoparticles (NPs) covered with a shell of silica and modified with the chelator N-(2-acetylaminoethyl)-N′-(3-triethoxysilylpropyl)thiourea. The new magnetic NPs enable rapid magnetic separation, thus leading to higher efficiency and accuracy. The extracted Hg(II) ions on the NPs were directly quantified using a mercury analyzer. Possible interferents are widely eliminated in this highly selective extraction process, and the NPs are not exerting an interfering effect either. The method has an enrichment factor of 100, and extraction recoveries are between 95 and 107 % when using 10 mg of the extracting NPs. The method works over a wide range of pH values and can be applied to even complex natural samples. The effects of pH value, extraction time, sample volume and adsorbent amount on the extraction efficiency were optimized. Under the optimal conditions, the detection limit is as low as 17 ng L −1 . The method was applied to the preconcentration and detection of Hg(II) in three natural water samples using the standard addition method.
A facile magnetic solid phase extraction using surface decorated nano-scale magnetic core-shell nanoparticles coupled with a direct mercury analyzer is proposed for trace-level mercury ions detection.
研究领域:
环境化学
·
分析化学
·
纳米材料科学
·
生物医学分析
·
重金属检测
✓ 已验证
DOI
高影响因子
NEW JOURNAL OF CHEMISTRY
·
2019
·Vol. 43
·期 26
·10297-10304
·
IF 3.069
Xi Xia,Wei Wei Ge,Haiyong Chen,Zhu Tao,Yunqian Zhang,Gang Wei,Kai Chen
In the present work, perhydroxylated cucurbit[6]uril {(HO)12Q[6]} and Keggin-type polyoxometallates (POMs) such as H3[PMo12O40] and H3[PW12O40] were used as basic building blocks, and interaction of (HO)12Q[6] of POMs in the acidic aqueous solutions yielded two types of supramolecular assemblies. Hybrids of (HO)12Q[6] with POM anions were obtained from (HO)12Q[6]-POMs-HCl (1M) systems, whereas (HO)12Q[6]-based supramolecular assemblies without POMs were obtained from (HO)12Q[6]-POMs-HCl (6M) systems. The structures of these two assemblies were analyzed by using single X-ray single crystal and powder X-ray diffraction methods, and the chemical and physical properties of these two assemblies were investigated by using the multi-point Brunauer–Emmett–Teller (BET) method, the Barrett–Joyner–Halenda (BJH) method, UV/vis measurements and so on. The results revealed that the (HO)12Q[6]-POMs system may offer a feasible route for the uptake and release of POMs, exhibit esterification and aqueous dyes degradation catalytic activities, and adsorb volatile organic compounds, yielding adsorbing materials with interesting photochemical properties.
研究领域:
化学
·
材料科学
✓ 已验证
DOI
高影响因子
JOURNAL OF CHROMATOGRAPHY B-ANALYTICAL TECHNOLOGIES IN THE BIOMEDICAL AND LIFE SCIENCES
·
2021
·
IF 3.205
Weili Xu,Jilong Li,Ji Feng,Zhibing Wang,Hanqi Zhang
A novel in-syringe temperature-controlled liquid–liquid microextraction based on solidified floating ionic liquid (in-syringe TC-LLME-SFIL) combined with high performance liquid chromatography was developed for the simultaneous determination of monuron, chlorotoluron, atrazine, monolinuron, propazine and prometryn in commercial vegetable protein drinks. The samples were deproteinized by trichloroacetic acid and further cleaned up by solid phase extraction column. The ionic liquid tributyldodecylphosphonium tetrafluoroborate ([P 4 4 4 12 ]BF 4 ) was used as extraction solvent and dispersed into the depurated sample solution to form fine droplets with the assistance of heating and vortex. With the help of an ice bath, the ionic liquid phase solidified and floated on the surface of aqueous phase. After separation from the aqueous phase, the solidified ionic liquids were dissolved with acetonitrile and the resulting solution was analyzed by high performance liquid chromatography. Some extraction parameters, including type and amount of adsorbent, type and amount of ionic liquids, amount of NaCl, melting temperature and time of ionic liquid, vortex time, pH of sample solution, ice bath temperature and time, were investigated and optimized by single-factor experiment, Plackett-Burman design and Box-Behnken design. The results showed that good linearities ( r ≥ 0.9994) were obtained in the concentration range of 7.8–1000.0 μg/L. The limits of detection and quantification were in the range of 0.25–2.59 μg/L and 0.82–8.63 μg/L, respectively. The spiked recoveries were 81.26–118.42% with the relative standard deviation (RSD, n = 3) lower than 8.17%. The present method was successfully applied to the simultaneous determination of triazine and phenylurea herbicides in vegetable protein drinks.
研究领域:
分析化学
·
食品科学
✓ 已验证
DOI
PubMed
高影响因子
ACS Applied Optical Materials
·
2023
·
IF 0
Long-Jing Wu,Rui Fu,Guozheng Huang,Rui-Lian Lin,Jing-Xin Liu
The design and construction of near-infrared (NIR) photochromic materials that show absorption and responsiveness in the NIR region remain a challenge. In this work, we prepared two triazine-bridged viologens, one being 2,4,6-tri(4-pyridinium)-1,3,5-triazine trichloride (TPA·Cl3) and the other one being its tribenzyl-substituted derivative (TPB·Br3). 1H NMR spectroscopy reveals that the cucurbit[7]uril (Q[7]) can bind with the two viologens to form quaternary inclusion complexes TPA3+@Q[7]3 and TPB3+@Q[7]3. Both inclusion complexes demonstrate NIR photochromic behavior, and the color changed from white to bluish green. Electron-spin resonance (ESR) spectra indicate that their photochromism is due to the formation of free radicals TPA•2+/TPB•2+. In addition, the inclusion complexes show photomodulable fluorescence emission. The excellent photochromic behavior and photomodulable fluorescence endow the inclusion complexes with practical utility in erasable inkless printing and anticounterfeiting.
研究领域:
化学
·
材料科学
·
物理化学
✓ 已验证
DOI
FOOD CHEMISTRY
·
2017
·
IF 4.529
Yuting Li,Tao Bao,Wei Chen
Increasing evidence indicates that crude extracts derived from mulberry confer protection against oxidative stress. However, the antioxidant capacity of mulberry extract among different cultivars remains elusive. The main objective of the present study was therefore to investigate the effect of black mulberry extract (BMB) and white mulberry extract (WMB) on ethyl carbamate (EC)-induced cytotoxicity and oxidative stress. This study showed that the contents of total phenolics, total flavonoids, total procyanidins, cyanidin- 3 - O -glucoside, cyanidin- 3 - O -rutinoside and pelargonidin- 3 - O -glucoside of BMB were higher than that of WMB. Moreover, our results showed that phenolics-abundant BMB was stronger than WMB in scavenging ABTS and DPPH free radicals. BMB was more effective in ameliorating EC-induced cytotoxicity by inhibiting excessive ROS generation, suppressing mitochondrial dysfunction and increasing GSH concentration in HepG2 cells than WMB. Taken together, our study revealed that BMB afforded better protection against EC-caused cytotoxicity than WMB.
研究领域:
植物学
·
毒理学
·
细胞生物学
✓ 已验证
DOI
高影响因子
MACROMOLECULAR CHEMISTRY AND PHYSICS
·
2020
·Vol. 221
·期 11
·2000075
·
IF 2.335
Rui Feng,Suyun Jie,Pierre Braunstein,Bo-Geng Li
(Thio)urea/base systems have been widely used in the ring-opening polymerization (ROP) of lactones based on their superior performance in activity and selectivity. Herein, a pyridyl-urea ( 6C-PU )/7-methyl-1,5,7-triazabicyclo[4.4.0]dec-5-ene catalytic system is used to prepare the polyesters with cyclic topology via the ROP of lactones in the absence of initiator under solvent-free conditions. The catalytic system shows high activity in the ROP of δ-valerolactone (δ-VL) and cyclic polyvalerolactones (PVLs) with high molecular weights and narrow molecular weight distribution are obtained despite the existence of some linear products generated during the precipitation process. The structure of the resulting polymers is determined by proton and carbon nuclear magnetic resonance spectra, matrix assisted laser desorption/ionization time of flight mass spectrometry, and intrinsic viscosity studies. A possible mechanism is proposed on the basis of NMR analysis and characteristics of polymerization. Thermal and mechanical properties of cyclic PVLs are investigated through differential scanning calorimetry, thermogravimetric analysis, and tensile test.
研究领域:
材料科学
·
有机化学
✓ 已验证
DOI
高影响因子
CRYSTENGCOMM
·
2018
·Vol. 20
·期 8
·1151-1157
·
IF 3.304
Qiangwen Fan,Xiaowei Duan,Hong Yan
The solid state [2 + 2] photocycloaddition of N,N′-diacyl-1,4-dihydropyrazines has been investigated using thiourea as a template to preorient the reactants in the crystalline state in a manner that is beneficial for the [2 + 2] photocycloaddition. The structures of the photoadducts, syn-dimers and cage-dimers, were determined using NMR and single-crystal X-ray diffraction. According to the topochemical principles used to assess the feasibility of solid state photochemical [2 + 2] cycloaddition, topological analysis of cocrystals consisting of the N,N′-diacyl-1,4-dihydropyrazines and thiourea, as well as the syn-dimers, was performed to investigate the influence of packing modes and non-covalent interactions on their solid state photoreactivity. The results showed that the solid state [2 + 2] reactivities of both the N,N′-diacyl-1,4-dihydropyrazines assembled using thiourea and the syn-dimers were controlled by the topochemical orientation of the potentially reactive double bonds and the H-bonding interactions within the adjacent reactive molecules.
研究领域:
有机化学
·
光化学
·
晶体工程
·
超分子化学
·
药物合成
✓ 已验证
DOI
高影响因子
JOURNAL OF CHEMICAL RESEARCH
·
2019
·
IF 0.67
Chunchun Chen,Weiwei Ge,Kai Chen,Zhu Tao,Yunqian Zhang,Qian Jiang Zhu
Cucurbit[8]uril (Q[8]) was used as the building block for the facile preparation of Q[8]-based supramolecular assemblies in aqueous HCl solutions (A). The Q[8]-based supramolecular assembly was constructed of Q[8] molecules held together through outer surface interactions of cucurbit[n]urils, and hydrogen bonding between latticed water molecules and portal carbonyl oxygens of Q[8]. The porous structure resulted in different adsorption properties for different fluorophore guests (FGs), including dyes and fused-ring compounds, and fluorescence enhancement or colour changes resulted in luminescent materials (FG@As). Moreover, some of the FG@A systems could selectively respond to certain volatile organic compounds, for which they can be used as solid sensors.
研究领域:
化学
·
材料科学
·
分析化学
✓ 已验证
DOI
高影响因子
MOLECULES
·
2018
·Vol. 23
·期 9
·2203
·
IF 3.098
Peiqi Chen,Xiangmin Song,Yongmei Fan,Weihao Kong,Hao Zhang,Ranfeng Sun
In order to find pesticides with insecticidal and antifungal activities, a series of novel benzoyl pyrimidinylurea derivatives were designed and synthesized. All target compounds were identified by1H-NMR spectroscopy and HRMS. Insecticidal and antifungal activity of these compounds were evaluated and the structure-activity relationships (SAR) were clearly and comprehensively illustrated. Compound7, with low toxicity to zebrafish (LC50= 378.387 µg mL−1) showed 100% inhibition against mosquito (Culex pipiens pallens) at 0.25 µg mL−1. Both compounds19and25exhibited broad-spectrum fungicidal activity (>50% inhibitory activities against 13 phytopathogenic fungi), which were better than those of the commercial pesticide pyrimethanil (>50% inhibitory activities against eight phytopathogenic fungi). Furthermore, compounds19and25exhibited protective activity againstSclerotinia sclerotiorumon leaves ofBrassica oleraceaL. during in vivo experiments.Keywords:benzoylpyrimidinylurea derivatives;antifungal activity;insecticidal activity;embryo toxicity;zebrafish
研究领域:
农药化学
·
植物保护
·
药物化学
✓ 已验证
DOI
PubMed
高影响因子
POLYMER ENGINEERING AND SCIENCE
·
2023
·Vol. 64
·期 2
·779-787
·
IF 3.2
Xiang Zhang,Zhenggang Xiao
Organic anticorrosion coatings (OACs) are the most effective, economical, and environmentally friendly protection strategy for metals. However, the traditional OACs usually inevitably suffer mechanical cracks during their service life. If not repaired in time, the resultant cracks in OACs will result in irreparable corrosion of the metal substrate. More detrimentally, these microcracks are not easily detectable at the initial stage. If OACs can autonomously heal their damage at the initial stage, the microcracks will be repaired in time and the metal substrate will be protected well. Thus, giving OACs the self-healing capability is a promising strategy for metal protection. Herein, an autonomously self-healing TiO 2 -reinforced silicone polyurea (SPU- g -TiO 2 ) elastomer was successfully designed as anticorrosion coating for Q235 carbon steel (QCS) protection. The SPU- g -TiO 2 elastomer matrix exhibited excellent stretchability with a maximum strain of 3826.72% and fast self-healing ability with an outstanding self-healing efficiency of 98.69% for 6 h without any external stimulus at room temperature. The QCS coated with SPU- g -TiO 2 showed excellent damage resistance and good anticorrosive ability, and it can self-heal the microcracks generated in its coating in time to prevent corrosive media corroding the internal mental substrate. This work has a positive guiding significance for the development of functional OACs to improve their protection for metallic materials. Highlights A bionic smart self-healing SPU- g -TiO 2 coating was successfully synthesized. The mechanical and self-healing properties are balanced using nanoparticles. The coating features excellent self-healing capability and stretchability. Q235 steel coated with SPU- g -TiO 2 shows good anticorrosive ability.
研究领域:
材料科学
·
腐蚀工程
·
聚合物化学
✓ 已验证
DOI
高影响因子
Evidence-based Complementary and Alternative Medicine
·
2015
·Vol. 2015
·期 1
·239749
·
IF 1.88
Zhiping Wang,Junbiao Wu,Qun Zhou,Yifei Wang,Tongsheng Chen
Berberine (Ber), an isoquinoline derivative alkaloid and active ingredient of Coptis, has been demonstrated to possess antidiabetic activities. However its low oral bioavailability restricts its clinical application. In this report, Ber nanosuspension (Ber-NS) composed of Ber and D- α -tocopheryl polyethylene glycol 1000 succinate (TPGS) was prepared by high pressure homogenization technique. Antidiabetic effects of Ber-NS relative to efficacy of bulk Ber were evaluated in streptozotocin (STZ) induced diabetic C57BL/6 mice. The particle size and zeta potential of Ber-NS were 73.1 ± 3.7 nm and 6.99 ± 0.17 mV, respectively. Ber-NS (50 mg/kg) treatment via oral gavage for 8 weeks resulted in a superior hypoglycemic and total cholesterol (TC) and body weight reduction effects compared to an equivalent dose of bulk Ber and metformin (Met, 300 mg/kg). These data indicate that a low dosage Ber-NS decreases blood glucose and improves lipid metabolism in type 2 diabetic C57BL/6 mice. These results suggest that the delivery of Ber as a nanosuspension is a promising approach for treating type 2 diabetes.
研究领域:
药剂学
·
药理学
·
分子药理学
·
药物递送系统
·
糖尿病研究
·
药物代谢
·
纳米医学
✓ 已验证
DOI
高影响因子
Materials
·
2024
·Vol. 17
·期 11
·2570
·
IF 3.1
Yu Kong,Rong Zhang,Boyang Li,Wei Zhao,Ji Wang,Xiao-Wen Sun,Huihui Lv,Rui Liu,Juan Tang,Biao Wu
Phosphates play a crucial role in drug design, but their negative charge and high polarity make the transmembrane transport of phosphate species challenging. This leads to poor bioavailability of phosphate drugs. Combretastatin-A4 phosphate (CA4P) is such an anticancer monoester phosphate compound, but its absorption and clinical applicability are greatly limited. Therefore, developing carrier systems to effectively deliver phosphate drugs like CA4P is essential. Anion receptors have been found to facilitate the transmembrane transport of anions through hydrogen bonding. In this study, we developed a tripodal hexaurea anion receptor (L1) capable of binding anionic CA4P through hydrogen bonding, with a binding constant larger than 104M−1in a DMSO/water mixed solvent.L1demonstrated superior binding ability compared to other common anions, and exhibited negligible cell cytotoxicity, making it a promising candidate for future use as a carrier for drug delivery.
研究领域:
药学
·
药物递送系统
·
药物化学
·
癌症研究
✓ 已验证
DOI
PubMed
高影响因子
危险品化学品经营许可证（带存储）