FOOD CHEMISTRY
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2021
·
IF 7.514
Wenwen Deng,Anqi Huang,Qutong Zheng,Long Yu,Xiao Li,Hankun Hu,Yuxiu Xiao
A novel density-tunable liquid-phase microextraction (DT-LPME) system was developed with high-density deep eutectic solvents (DESs) as extractant and low-density organic solvents as emulsifier and density regulator. DES-rich phase was induced to form in the bottom or in the top by adjusting the emulsifier amount. This system was used to directly extract polycyclic aromatic hydrocarbons (PAHs) from liquid and solid foods, and the obtained DES-rich phase was easy to be collected for quantification. The method (LPME with HPLC-fluorescence detector) has linearity (R 2 > 0.9974), detection limits of 0.6–4.2 ng L -1 for liquid foods and 0.05–0.35 ng g −1 for solid foods, recoveries of 86.2–114.9%, and intra-day/inter-day RSDs below 6.6%. The method was applied to detect PAHs in real samples, and the PAHs residue was found in honey and five solid foods. The DT-LPME method is simple, fast, green and suitable for direct extraction of analytes from both liquid and solid samples.
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COLLOIDS AND SURFACES B-BIOINTERFACES
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2020
·
IF 4.389
Qiang Hu,Kesi Wang,Liyan Qiu
Clinical extensive application of indocyanine green (ICG) is limited by several drawbacks such as poor bioenvironmental stability, aggregate propensity, and rapid elimination from the body, etc. In this study, we construct a novel amphiphilic mPEG-ACA-ICG conjugate by modifying synthetic heptamethine cyanine derivative ICG-COOH with a hydrophobic linker 6-aminocaproic acid (ACA) and amino-terminal poly(ethylene glycol) (mPEG-NH 2 ). The as-prepared mPEG-ACA-ICG conjugate has the ability to self-assemble into micellar aggregates in an aqueous solution with a lower CMC value than mPEG-ICG conjugate without ACA linker. More importantly, compared with free ICG and mPEG-ICG conjugate, mPEG-ACA-ICG nanomicelles exhibited better stability and higher photothermal conversion efficiency upon near-infrared light irradiation due to the intramolecular introduction of a hydrophobic ACA segment. In our in vivo experiment, mPEG-ACA-ICG nanomicelles ensured the formidable effect on tumor photothermal therapy (PTT) and the maximum tumor inhibition rate reached 72.6 %. In addition, real-time determination ability for fluorescence image-guided surgery (FIGS) of mPEG-ACA-ICG nanomicelles was also confirmed on tumor xenograft mice model. Taken together, mPEG-ACA-ICG conjugate may hold great promise for non-invasive cancer theranostics.
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COLLOIDS AND SURFACES B-BIOINTERFACES
·
2020
·
IF 4.389
Hualu Lai,Xin Ding,Junxian Ye,Jie Deng,Shengmiao Cui
Curcumin (CUR) display promising antitumor effects, however, the poor water solubility severely limited its clinical application. To overcome this problem, polymeric nanocarriers have been adopted for targeted CUR delivery and enhanced cancer therapy. In this paper, utilizing an acid-labile hydrazone linkage, hydrophobic CUR was conjugated with hydrophilic hyaluronic acid (HA) to form amphiphilic HA-ADH-CUR conjugates, which could subsequently self-assemble to form nanoparticles (HA@CUR NPs) in aqueous. The in vitro drug release experiments showed that HA@CUR NPs exhibited a pH-responsive CUR release behavior, and the release rate of CUR was 73.5 % in pH 5.0. Further, in vitro cell experiments showed HA@CUR NPs could be efficiently internalized by 4T1 and MCF-7 cancer cells through CD44 receptor mediated endocytosis and successfully release CUR in acidic lysosome environment for chemotherapy. In vivo antitumor experiments showed that, compared to free CUR, HA@CUR NPs could efficiently cumulate in tumor site via EPR effect and CD44 mediated endocytosis, achieve superior therapeutic effect for tumor growth suppression. Therefore, HA@CUR NPs were a highly promising nanocarrier for hydrophobic CUR to realize enhanced cancer therapy with good biosafety.
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TALANTA
·
2020
·
IF 5.339
Yayan Tong,Qingxiang Zhou,Yi Sun,Xueying Sheng,Boyao Zhou,Jingyi Zhao,Jinghan Guo
Polyamidoamine dendrimer decorated Fe 3 O 4 magnetic nanoparticles was synthesized and grafted with 4-mercaptobenzoic acid (4-MBA). The resulting material was utilized to develop an effective magnetic solid phase extraction method in combination with high performance liquid chromatography for trace determination of polycyclic aromatic hydrocarbons including phenanthrene (PHE), anthracene (ANT), fluoranthene (FLT), pyrene (PYR) and benzo(a)pyrene (BaP). The MNPs@G3.0@4-MBA exhibited to be an efficient extracting medium due to the existence of terminal benzene ring groups, the internal pores, and strong hydrophobic interactions and π-π interactions. The experiments demonstrated that the proposed method possessed excellent linearity in the concentration range of 0.1–300 μg L −1 with correlation coefficients (R) larger than 0.997, and the limits of detection (LODs, S/N = 3) according to the ratio of signal to noise equal to three of PHE, ANT, FLT, PYR and BaP were 0.014 μg L −1 , 0.032 μg L −1 , 0.055 μg L −1 , 0.027 μg L −1 and 0.039 μg L −1 , respectively. The proposed method was applied to real water samples and the spiked recoveries were over the range of 92–99%. The results showed that the method earned good repeatability and high sensitivity, and the as-prepared materials were stable and reusable, which displayed that the proposed method would have a wonderful application prospect.
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JOURNAL OF MOLECULAR LIQUIDS
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2020
·
IF 5.065
Xiaoxing Lu,Shaoxia Xie,Jian Kuang,Hujun Xie
A comprehensive experimental investigation on the microstructures of microemulsion constructed with Gemini surfactant has been carried out. The structural transition of the microemulsion system, 14-4-14/1-propanol/ n -heptane/water, from water-in-oil (W/O) to bi-continuous (B.C.) has been characterized by electrical conductivity and cyclic voltammetry . Being a typically percolative system, spherical nanodroplets are observed in the W/O system, while interlinks of water and oil continuous phases are observed in the middle phase, as confirmed by cryo-TEM. Most importantly, the role of water is clearly revealed. Increasing the water content results in size enhancement as well as improvement of micropolarity and diffusion behavior. Results of DSC measurements suggest that free water dominates only at high total water content. The unfrozen water which is not detected by DSC takes a considerable amount in the W/O system at low total water content, while the interphasal water reaches over 50% of total water in the middle phase system.
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ENVIRONMENTAL POLLUTION
·
2021
·
IF 8.071
Zaiming Chen,Jianfei Wang,Yuefeng Wang,Bing Li,Meizhen Wang
Pyrogenic char (biochar) with a high sorption capacity (B-HSC) can sequester hazardous chemicals (e.g., phenanthrene). However, when sorption inhibits bioavailability of some functional chemicals (e.g., the herbicidal efficacy of diuron in soil), biochar with a low sorption capacity (B-LSC) is required to prevent sorption effects. The pyrolytic B-HSC generation has been reported, but information on B-LSC formation is scarce. How fast B-HSC and B-LSC could be generated is unknown until now. Here, biochars were rapidly prepared (the shortest heating time reached 5 min and the cooling time reached < 30 min) by a direct-pyrolysis method by directly exposing packaged rice straw and pine wood to 350 °C, 500 °C and 700 °C and out-of-furnace cooling at room temperature. The sorption of diuron, phenanthrene , and twelve other chemicals was investigated. B–HSCs were obtained within 30 min of rice straw pyrolysis , and the biochar K d values quickly increased to 7-730-fold that of the raw biomass as –OH and C–O–C in (hemi)cellulose of rice straw rapidly degraded, increasing hydrophobic interactions between the char and chemicals (solubility ≤ 82.8 g/L). In contrast, B-LSCs were generated within 30 min of PW pyrolysis, and the K d values of the biochars were 0.2–3.0-fold that of the raw biomass, as the surface area development and hydrophobicity-driven sorption were probably delayed by the late degradation of lignin aromatic C–O and phenolic –OH. Biochar amendment revealed an enhancement effect of B-HSC but not of B-LSC on soil sorption. The fast formation of B-LSC and B-HSC provides a guide to develop time- and cost-effective technique in pyrolytically producing weakly or strongly sorbing biochars for organic chemical management.
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Soft Matter
·
2021
·Vol. 17
·期 9
·2490-2499
·
IF 3.679
Meihua Gao,Na Du,Zhiyin Yao,Ying Li,Nan Chen,Wanguo Hou
Simple single-chain amphiphiles (SCAs) can form vesicular structures in their single-component aqueous solutions, which has attracted great attention, but the understanding of their aggregation behavior is still limited. In this work, the aggregation behavior of 4-dodecylbenzene sulfonic acid (DBSA), a typical simple SCA, in water was investigated. The structure and properties of the aggregates formed were determined. In particular, the effect of wet–dry cycles on the structures of aggregates was examined. The mechanisms of aggregate formation and structural transition were discussed. It was found that the increase of DBSA concentration can drive the occurrence of a micelle-to-vesicle transition, showing a critical micelle concentration and critical vesicle concentration of ∼0.53 and 2.14 mM, respectively. The vesicles formed coexist with micelles in solution, with a unilamellar structure and ∼80 nm size, and exhibit size-selective permeability. In addition, the vesicles show remarkable stability upon long-term storage, exposure to high temperature, and freeze–thaw cycles. The H-bonding interaction between DBSA species and the interdigitated structure of alkyl chains in bilayers play a key role in the formation and stability of DBSA vesicles. Interestingly, it was found that the wet–dry cycle can induce a micelle-to-vesicle transition and an obvious increase in the size of the original vesicles, accompanied by the formation of some multilamellar vesicles. This work provides a better understanding of the aggregation behavior of simple SCAs in their single-component aqueous solutions.
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MICROCHEMICAL JOURNAL
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2020
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IF 3.594
Zhengdong Shen,Haiying Wang,Qian Yu,Qiang Li,Xiaomin Lu,Xianming Kong
The accumulated polycyclic aromatic hydrocarbons (PAHs) in edible oil can bring serious health concerns because of their carcinogenic features. PAHs could accumulate in edible oil from contaminated environment or food stuff. In this study, the combination uses of on-site thin layer chromatography and surface enhanced Raman scattering (SERS) spectroscopy has been successfully displayed to identify PAHs from edible oil samples. Diatomite which is a kind of porous biosilica was used to construct stationary phase on TLC plate, the photonic crystal feature of diatomite is beneficial for SERS enhancement. The highly-porous stationary phase composed of porous diatomite with void shell structure could promote mobile phase interaction with the stationary phase, which leading to improved mass transfer, uniformity and analyte resolution compare with the conventional silica gel plate. The edible oil (1 µL) was directly applied to the diatomite plate without pretreatment, and subjected to TLC separation. The polarity of target analytes was calculated for eluent optimization, on which four compounds of PAHs(benzo[a]pyrene, pyrene, anthracene and indeno[1,2,3-cd] pyrene) were successfully separated by using hexane/chloroform (15/1, v/v) as eluent, including compounds with similar polarity(benzo[a]pyrene 0.0477, indeno[1,2,3-cd] pyrene 0.6545, pyrene and anthracene are 0). 2 µL of Au colloid at 2.4 × 10 −7 M were transferred onto the diatomite plate for the SERS measurement. The limit of detection was found to be nearly at 1 ppm. The obtained results can easily identify the four compounds of PAHs in edible oil by their own characteristic Raman peaks. This proposed method provides a simple, instant and effective strategy for on-site identification PAHs from food samples.
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ANALYTICAL AND BIOANALYTICAL CHEMISTRY
·
2021
·Vol. 413
·期 7
·1983-1997
·
IF 4.157
Jing Qi,Chen Liyuan,Zhao Qiaowei,Zhou Peipei,Li Yanyan,Wang Huili,Wang Xuedong
Herein, we developed a novel effervescence-assisted dual microextraction method, abbreviated as EM-LPSH, using lighter-than-water phosphonium-based ionic liquids (LPILs) and switchable hydrophilic/hydrophobic fatty acids (SHFAs). The EM-LPSH method was utilized for quick enrichment/extraction of polycyclic aromatic hydrocarbons (PAHs) in edible oils. Owing to lower density than water, LPILs used as the first extractant were floated on the upper layer of the aqueous phase, leading to a convenient separation/collection compared with traditional heavier-than-water imidazolium-based ionic liquids. Interestingly, SHFAs play triple functions: a dispersive solvent in the microextraction process, an acidic source in effervescent reaction, and the second extractant in dual microextraction, due to switchability from hydrophilicity to hydrophobicity. Consequently, the integration of LPILs with SHFAs greatly enhanced the extraction efficiency for PAHs owing to the quick dual microextraction process. Some important variables were rigorously optimized using a one-factor-at-a-time approach. Under optimized conditions, the EM-LPSH/HPLC-FLD method provided a wide linear range (0.07~0.63–200 μg kg −1 ), satisfactory recovery (80.12–103.27%), and low limit of detection (0.02–0.19 μg kg −1 ), as well as high intra-day and inter-day precision (0.03–6.55) for six PAHs in edible oils. By using certified reference material in olive oil samples (GBW10162), the recoveries ranged from 97.40 to 98.39%, demonstrating high accuracy and precision. According to the detected levels of PAHs in six unheated and heated oils, their edible safety was evaluated in detail. In short, the newly developed method is simple, convenient, and highly efficient, thereby showing great prospects for application in conventional monitoring of trace-level PAHs in edible oils.
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ACS Applied Materials & Interfaces
·
2020
·
IF 8.758
Yinying Sheng,Junjie Yang,Xueyang Zhao,Hui Liu,Shaogang Cui,Lianxi Chen,Rong Zeng,Xiaojian Wang,Chi-Hsien Huang,Wei Li
Zinc (Zn) alloys are promising alternatives to magnesium (Mg)- and iron (Fe)-based alloys because of their moderate corrosion rate and superior biocompatibility. To reduce the mass release of Zn2+ and improve the biocompatibility of Zn implants, the biomimetic zwitterionic polymer layer (phosphorylcholine chitosan—PCCs) was immobilized on the plasma-treated Zn1Mg surface. It is the chemical bonds between the −NH2 groups of the PCCs chain and O–C═O (C═O) groups on the plasma-treated Zn1Mg (Zn1Mg-PP) that contributes to the strong bonding strength between the film and the substrate, by which the PCCs (approx. 200 nm thick) layer can bear a 5.93 N normal load. The electrochemical impedance spectroscopy (EIS) results showed that the PCCs layer remarkably increased the resistance against corrosion attack, protecting substrates from over-quick degradation, and the protective effect of the layer with a thickness of 200 nm lasts for about 24 h. The corrosion products of Zn1Mg-PP-PCC in NaCl solution were determined as Zn5(OH)8Cl2·H2O and Zn3(PO4)2. Besides, the bulk Zn1Mg can trigger more aggressive macrophage activity, while the surface of Zn1Mg-PP and Zn1Mg-PP-PCC and their corrosion products (Zn3(PO4)2) tend to promote the differentiation of macrophages into the M2 phenotype, which is beneficial for implant applications.
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CHEMICAL ENGINEERING JOURNAL
·
2021
·
IF 13.273
Sushuang Li,Yinhua Wan,Shiwei Guo,Jianquan Luo
Removal of organic micropollutants (OMPs) in the wastewater treatment is greatly important due to their adverse effects on human health and ecosystem. In this work, we provide a new perspective to prepare graphene oxide (GO) nanofiltration (NF) membrane with narrow pore size distribution for robust removal of OMPs. Ferric ions (Fe 3+ ) mediated GO nanosheets are firstly used to prepare GO membrane, then the membrane surface is modified by a targeted coating layer consisting of tannic acid-aminopropyltriethoxysilane (TA-APTES) via their strong affinity to Fe 3+ , where the larger membrane defects with more Fe 3+ would be patched by thicker TA-APTES. Such “speckled” TA-APTES coating can simultaneously enhance antifouling ability and regulate nanochannels of the GO membrane. The resulted GO membrane shows high and steady rejections on various OMPs, even in the long-term operation, cross-flow filtration or under high-pressure. This work proposes an innovative idea for constructing hydrophilic surface and narrow pore size distribution of NF membrane.
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MICROCHIMICA ACTA
·
2020
·Vol. 187
·期 4
·1-8
·
IF 6.232
Li Lin,Han Dandan,Wang Mingwei,Han Yehong,Yan Hongyuan
A composite was synthesized from two-dimensional molybdenum disulfide (MoS 2 ) nanosheets and hypercrosslinked polymers (HCP), and the composite was characterized by infrared spectroscopy, scanning electron microscopy, and specific surface area. The fluffy and porous structure and multiple adsorption sites (π-interaction, static electricity, hydrogen bonding) make it ideal for use as an adsorbent. A pipette tip solid-phase extraction with the composite as the adsorbent combined with HPLC–FLD was developed to determine trace amounts of polycyclic aromatic hydrocarbons (phenanthrene, anthracene, fluoranthene, pyrene, benzo(α)anthracene) in environmental water. Under optimal extraction conditions, the method has a wide linear range (0.5–100 ng mL −1 ) and low limit of detection (0.024–0.099 ng mL −1 ), and the recoveries of PAHs from spiked environmental water were 73.8% to 123.6% (relative standard deviation ≤ 6.7%, n = 3).
Schematic representation of a three-dimensional molybdenum disulfide–ethylenediamine–hypercrosslinked polymer composite (MoS 2 –EDA–HCP) using pipette tip solid-phase extraction adsorbent for extracting trace levels of polycyclic aromatic hydrocarbons (PAHs) prior to HPLC–FLD. HCP, hypercrosslinked polymer; MoS 2 , molybdenum disulfide; EDA, ethylenediamine
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危险品化学品经营许可证（带存储）