JOURNAL OF NANOSCIENCE AND NANOTECHNOLOGY
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2016
·Vol. 16
·期 1
·242-245
·
IF 1.338
Sun Ke Ke,Li Ling,He Yu Qi,Fan Lu,Wu Ya Qi,Liu Li
A hybrid HKUST-1/GO composite was synthesized and its drug loading and drug release abilities were investigated. The adsorption of IBU (ibuprofen) onto the surface of HKUST-1/GO and HKUST-1 composites was compared, and it was found that the addition of GO enhanced both IBU loading and
stability. The addition of GO also enhanced the specific surface area. Drug release experiments on IBU loaded HKUST-1 and HKUST-1/GO were conducted, and it was found that drug release of HKUST-1/GO was slower, which can be explained by the hydrogen bonding between GO and IBU. It can be concluded
that the addition of GO not only enhances drug loading, but can also achieve a more desirable slow-release of the drug.
研究领域:
材料科学
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药剂学
·
纳米技术
✓ 已验证
DOI
PubMed
高影响因子
Journal of Saudi Chemical Society
·
2024
·
IF 5.8
Zhengjie Li,Miao Liu,Chunxia Fang,Huanshu Zhang,Tianyi Liu,Yixian Liu,Heli Tian,Jilong Han,Zhikun Zhang
The widespread use and subsequent accumulation of florfenicol (FFC), a common antibiotic, through the food chain poses significant risks to aquatic ecosystems and human health, necessitating effective strategies for its removal from water bodies. To solve the challenge, herein, we developed a novel aluminum-based metal–organic framework CAU-1, engineered for the efficient adsorption of FFC. CAU-1 contains the plentiful –NH 2 and μ-OH groups with the positively charged on the surface. In the adsorption process, CAU-1 perform hydrogen bonding interactions with FFC’s functional groups (−F, –OH, −Cl, –NH–, and −SO 2 –). Furthermore, the positively charged surface of CAU-1 enhances FFC adsorption via electrostatic attraction together. FFC adsorption equilibrium on CAU-1 is attained within 180 min with a monolayer adsorption capacity of 386 mg/g at 303 K, surpassing most of the reported adsorbents. The exothermic FFC adsorption process on CAU-1 remains largely unaffected by coexisting ions. Additionally, CAU-1 can be efficiently regenerated using a mixed solution of 0.1 M HCl and ethanol–water as an eluent. This work highlights CAU-1’s potential as an effective adsorbent for FFC removal, emphasizing the importance of tuning or designing surface functional groups on adsorbents to boost their adsorption capabilities.
研究领域:
环境科学
·
材料科学
✓ 已验证
产品关联
DOI
高影响因子
INDUSTRIAL & ENGINEERING CHEMISTRY RESEARCH
·
2025
·
IF 3.9
Rui Feng,Zhou Fang,Runxi Zhang,Xiaoyan Hu,Tianbo Li,Wei Zhou,Feifei Yang,Xinlong Yan,Shijian Lu
Direct hydroxylation of benzene to phenol is a more environmentally friendly way to generate phenol compared with the traditional method. This study developed vanadium-modified hollow-structured titanium silicate-1 (TS-1) as a catalyst for the effective hydroxylation of benzene to phenol under moderate conditions using hydrogen peroxide as an oxidant. The synthesis of TS-1 zeolites has been improved using traditional hydrothermal, crystal seed, and dissolution–recrystallization techniques. Compared with conventional TS-1, hollow-structured TS-1 exhibited a higher mesopore volume and surface area. Later, vanadium doping increased the charge density associated with the framework Ti centers and acid site content. In the radical reaction process, the adsorption and activation of benzene on highly reactive Ti–OOH intermediates, as well as the improvement of performances toward benzene hydroxylation to phenol, were facilitated by the increase in the concentration of open active centers and acid and electron characteristics.
研究领域:
催化化学
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环境科学
·
材料科学
✓ 已验证
产品关联
DOI
高影响因子
SEPARATION AND PURIFICATION TECHNOLOGY
·
2024
·
IF 8.1
Zhu Liu,Shoulu Yang,Zhongwei Wang,Ning Ji,Xingong Li,Yingfeng Zuo
The effect of moisture on the volatile organic compound (VOC) adsorption on biomass-derived metal–organic framework composites is significant in practical applications. In this study, wood-based metal organic frameworks (MOF199-W) and hydrophobic MOF199-W (HMOF199-W) were developed using HKUST-1 (MOF199) and long alkyl chains to investigate the adsorption performance of toluene and enhance the selectivity of adsorption under high humidity conditions. The results demonstrated that HKUST-1 could be anchored onto the surface of wood vessels and fibers through coordination with Cu 2+ , resulting in an improved surface area in comparison to natural wood. The toluene adsorption capacity of MOF199-W with a 20 % loading was comparable to that of an equivalent amount of MOF199, with adsorption capacities of 323.5 mg/g and 369.9 mg/g, respectively. Further, the Yoon-Nelson model was found to adequately describe the dynamic adsorption process. Following the introduction of long alkyl chains, MOF199 and MOF199-W were endowed with strong hydrophobic character (water contact angle of 107.0 ◦ , 104.0 ◦ , and water uptake of 30.5 mL/g, 55.3 mL/g). With the increase in humidity, the adsorption performance of MOF199 and MOF199-W for toluene sharply decreased, but HMOF199 and HMOF199-W still maintained the adsorption capacities at 304.7 mg/g and 226.7 mg/g, even under 80 % RH conditions. Therefore, HMOF199-W has shown great potential in wooden building materials with the ability for toluene capture under humid conditions.
研究领域:
材料科学
·
环境科学
✓ 已验证
产品关联
DOI
高影响因子
CHEMICAL ENGINEERING JOURNAL
·
2024
·
IF 13.3
Qiang Ma,Fan Li,Xianglong Zhang,Bowen Yang,Yingjie Zhang,Qingyuan Wang,Qihong Wu,Jin Huang,Jiming Hao
With the rapid development of ore refining, coal power plants, and mining, aqueous thallium pollution in natural waters has been reported over the past few decades. However, few thallium control technologies have been put into practice. In this study, a modified MOF adsorbent, MnO 2 @HKUST-1(MOH), was fabricated. Its chemical component shift, thermal stability, and microstructure changes during thallium adsorption were analyzed using TGA, XRD, XPS, and TEM-EDS techniques. The results showed a promising Tl + removal rate of over 90 %, and an adsorption capacity of 178.8 mg/g was obtained at a pH of 5 and a temperature of 293 K. The dynamic behavior of Tl + adsorption on MOH was simulated using power rate law expression (PRL), pseudo-first-order model (PFO), and pseudo-second-order model (PSO), which revealed a superior selection of Tl + among other competing heavy metal ions (Cr 3+ , Fe 3+ , Ca 2+ , Zn 2+ , and Cu 2+ ). The Tl + removal mechanism was further studied, which was mainly forced by surface adsorption/desorption. Based on its efficient Tl + removal rate, high adsorption capacity, promising regeneration property, and economical price, the MOH adsorbent has the potential to be a feasible option for smelting, ore refining, packaging, and testing wastewater treatment.
研究领域:
环境科学
·
材料科学
✓ 已验证
产品关联
DOI
高影响因子
Frontiers in Pharmacology
·
2025
·
IF 4.8
Ji Yang,Peng Guo,Hongtao Luo,Xin Tang,Wei Liu,Xiaolin Ren
Background: Current therapeutic options for inflammatory bowel disease (IBD) remain suboptimal due to limited efficacy, significant side effects, and high relapse rates, necessitating novel treatment strategies. Lumefantrine, a clinically established antimalarial drug, emerges as a compelling repurposing candidate based on its putative anti-inflammatory activity, though its efficacy and mechanism in IBD remain unexplored.Methods: A murine IBD model was induced by 3% dextran sulfate sodium (DSS). Mice received oral Lumefantrine (20 mg/kg/day) for 7 days. Disease progression was monitored via disease activity index (DAI) scoring and histological analysis. Serum cytokines (IL-1β, IL-6, TNF-α) and colonic inflammatory mediators (Cox-2, iNos) were quantified by ELISA and qPCR. Tight junction proteins (Claudin-1, ZO-1) were assessed by immunohistochemistry and Western blot. Molecular targets were identified through computational docking and pull-down assays. Additionally, NF-κB signaling modulation was assessed in lipopolysaccharide (LPS)-stimulated intestinal epithelial cells (IEC-6 and NCM460) via Western blot analysis.Results: Oral administration of Lumefantrine significantly attenuated disease activity index (DAI) scores and restored intestinal barrier integrity through upregulation of epithelial tight junction proteins Claudin-1 and ZO-1. Treated mice exhibited reduced serum levels of IL-1β, IL-6 and TNF-α, along with decreased colonic expression of inflammatory mediators cyclooxygenase-2 (Cox-2) and inducible nitric oxide synthase (iNos). Computational and experimental approaches identified FLI-1 a transcription factor upregulated in IBD colon tissues as Lumefantrine’s direct binding target. This interaction mediated suppression of NF-κB signaling, specifically downregulating phosphorylation of IκBα and p65 in LPS-stimulated intestinal epithelial cells.Conclusion: Lumefantrine ameliorates experimental colitis through FLI-1-dependent inhibition of the NF-κB pathway, demonstrating high repurposing potential as an IBD therapeutic.
研究领域:
免疫学
·
分子生物学
·
药理学
·
转化医学
✓ 已验证
产品关联
DOI
PubMed
高影响因子
Non-coding RNA Research
·
2025
·
IF 4.7
Ying Wen,Yitong Li,Danhua Zhang,Ziru Liu,Hong Liu,Xiejia Li,Wei Wu,Liyun Zeng,Qiongyan Zou,Wenjun Yi
The prevalence of secondary hyperparathyroidism (SHPT) in advanced chronic kidney disease (CKD) exceeds 80%. Our previous study indicated that photodynamic therapy (PDT) has potential for treating SHPT. Long noncoding RNA (lncRNA) is involved in various oxidative stress and apoptotic processes, but the molecular mechanism remains unreported. In this study, we found that PDT induced apoptosis in SHPT through reactive oxygen species (ROS) accumulation. The expression of metastasis-associated lung adenocarcinoma transcript 1 (MALAT1) and heme oxygenase 1 (HO-1) within SHPT was upregulated after PDT. Inhibition of MALAT1 increased PDT-induced ROS, which promoted the apoptosis. Pearson correlation analysis confirmed that there was a positive correlation between MALAT1 and HO-1, and MALAT1 inhibition down-regulated HO-1, whereas concomitant overexpression of HO-1 was able to eliminate the PDT-induced ROS and inhibit apoptosis. The direct binding of MALAT1 to Kelch-like ECH-associated protein 1 (Keap1) protein was confirmed by high-throughput sequencing, RNA pulldown, silver staining and western blotting assays. Si-Keap1 was able to rescue the down-regulation of HO-1 caused by MALAT1 inhibition, restoring the elimination of ROS by HO-1 and attenuating the effect of PDT. In addition, PDT effectively reduced parathyroid hormone (PTH) secretion in SHPT rats, and this effect was further enhanced in combination with MALAT1 inhibitors. Overall, MALAT1 activates downstream HO-1 expression by binding to Keap1, thereby reducing ROS and inhibiting apoptosis, which in turn mediates PDT resistance in SHPT. Inhibition of MALAT1 significantly enhanced the efficacy of PDT, suggesting a potential therapeutic target for improving PDT for SHPT outcomes.
研究领域:
医学
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分子生物学
✓ 已验证
产品关联
DOI
PubMed
高影响因子
SOLID STATE SCIENCES
·
2025
·
IF 3.3
Tingting Yan,Han Li,Dongyang Xi,Linan Liu,Dinghan Jin,Lei Sun
We synthesized the energetic molecular perovskite DAI-1 (C 48 H 112 I 24 N 16 Na 8 O 96 ) and investigated its behavior under high pressure using high-pressure Raman spectroscopy. DAI-1 exhibits an ABX 3 cubic perovskite structure, with significant changes in its Raman spectrum occurring between 4.3 and 7.1 GPa, signaling a phase transition. Releasing the pressure after applying it up to 12.3 GPa showed that the Raman spectrum did not return to its original state, indicating an irreversible phase transition. Furthermore, we conducted simulations to analyze the trend of changes in the crystal structure under pressure. This study serves as a reference for in-depth research on the high-pressure behavior of DAI-1 and other related substances.
研究领域:
材料科学
·
物理学
✓ 已验证
产品关联
DOI
高影响因子
Gas Science and Engineering
·
2024
·
IF 0
Xuebi Du,Dawei Shao,Yinhua Wan
Metal-organic frameworks (MOFs) have shown potential as nanofillers for the selective capture of specific gases in mixed matrix membranes (MMMs). This study introduces an efficient method, utilizing a mild (100 °C) reaction condition and a short reaction time (20 min), for the synthesis of MOF-808(Ce) nanocrystals. The MOF-808(Ce) that is obtained exhibits porous characteristics, a notable affinity for CO 2 , and robust intermolecular interactions with PIM-1. Furthermore, this study pioneers the incorporation of MOF-808(Ce) as a filler into PIM-1, with varying loadings, to create PIM/MOF-808 MMMs for the purpose of CO 2 separation. Consequently, the MMMs containing 2 wt% MOF-808(Ce) demonstrate high CO 2 permeability of 6854 Barrer and CO 2 /N 2 selectivity of 23.2, which is far surpasses 2008 upper bound from Robeson and approaches the refined 2019 upper bound from MeKenow. A comparative analysis demonstrates the efficacy of MOF-808(Ce) as a filler in PIM-1 for the purpose of CO 2 separation.
研究领域:
材料科学
·
环境科学
·
化学工程
✓ 已验证
产品关联
DOI
INDUSTRIAL & ENGINEERING CHEMISTRY RESEARCH
·
2024
·
IF 3.8
Tingting Lu,Yufei Sun,Zhiwei Wang,Shuo Zhang,Yongsheng Yang,Hongdan Zhang,Peng Cheng,Zhen Zhao
A facile and effective post-treatment route has been systematically applied for the preparation of hierarchical zeolites SAPO-18 using oxalic acid or sodium citrate etching solution. The influence of acidic or alkaline post-treatment on the relative crystallinity, morphology, chemical composition, pore characteristics, and acidity of a series of zeolites SAPO-18 was investigated by X-ray diffraction, scanning and transmission electron microscopy, X-ray fluorescence spectroscopy, nitrogen adsorption–desorption, temperature-programmed desorption of ammonia, and solid-state magic angle spinning nuclear magnetic resonance spectroscopy experiments. Post-treatment led to an increase in mesoporosity by widening the micropores, but a decrease in the acid strength of zeolite SAPO-18 samples. The effects of mesoporosity and acidity on the catalytic cracking performance of zeolite SAPO-18 samples were studied. The hierarchical zeolite SAPO-18 sample post-treated by alkaline sodium citrate solution with suitable concentration exhibited better catalytic conversion and improved light olefin selectivity in cracking of 1-butene.
研究领域:
材料科学
·
催化化学
✓ 已验证
产品关联
DOI
高影响因子
PHYSICS LETTERS A
·
2024
·
IF 2.3
Ting-ting Yan,Ran Jiang,Dong-yang Xi,Long Ma,Dan-dan Zhang,Yi-fei Xu
This study investigated the structural stability of 1-methylhydantoin (1-MH, C 4 H 6 N 2 O 2 ) Form-I at room temperature using Raman spectroscopy and a diamond anvil cell (DAC) for high-pressure experiments. Two phase transitions were identified at pressures of 0.6–1.7 GPa and 3.4–6.7 GPa. After complete release of pressure, the spectrum aligned with the Raman spectrum at ambient pressure, indicating reversibility of the phase transition. Analysis of Hirshfeld surface energy and fingerprints was conducted to assess changes in intermolecular interactions, revealing that the phase transitions are associated with rearrangements in the hydrogen-bonded network.
研究领域:
物理化学
·
材料科学
✓ 已验证
DOI
高影响因子
Cell Metabolism
·
2025
·
IF 30.9
Ming-Ming Wu,Yan-Chao Yang,Zhi-Qiang Hu,Jie-Yu Chang,Han Xiao,Chang Miao,Bo-Wen Zhang,Zhi-Xi He,Di Zhu,Yu-Ran Duan,Shuo Wang,Jian-Yu Liu,Zhan-Peng Guo,Yu Sun,Dan-Yang Liu,Miao Yu,Yue Zhang,Jian-Jun Mao,Shuai Jiang,Bing-Kun Zhang,Zhu Mei,Jun Gao,Chen Liang,Qiu-Shi Wang,Chang-Jiang Yu,Dan Zhao,Cheng-Hui Yan,Yue Li,Zhen-Wei Pan,Zheng Chen,Da-Qian Xu,Tong Liu,Yong Ji,Zhi-Ren Zhang
Immune checkpoint inhibitor (ICI) therapies increase the risk of metabolic syndrome; the underlying mechanisms remain elusive. We show that an anti-PD-1 antibody targets macrophage PD-1 to reduce energy expenditure without affecting food intake, augmenting the susceptibility of mice to high-fat diet (HFD)-induced obesity and systemic metabolic disorders. Mechanistically, lipopolysaccharide (LPS) activates Unc-51-like autophagy activating kinase 1 (ULK1) in a mammalian target of rapamycin (mTOR)-dependent manner. Activated ULK1 phosphorylates PD-1 at Thr250 to inhibit FBXO38-mediated PD-1 ubiquitination and degradation by disrupting FBXO38-PD-1 binding. Phosphorylated PD-1 interacts with inositol-requiring enzyme 1α (IRE1α) and attenuates IRE1α autophosphorylation to suppress endoplasmic reticulum (ER) stress-mediated inflammatory responses. Suppressing IRE1α alleviates HFD-induced metabolic disorders in macrophage-specific PD-1 knockout mice by rescuing the reduced energy expenditure. Our findings highlight the critical role of macrophage PD-1 at the intersection of immune checkpoint blockade, energy expenditure, and metabolic dysfunction. The underscored moonlighting function of macrophage PD-1 may provide a new rationale for combating ICI therapy- and HFD-induced metabolic diseases.
研究领域:
免疫学
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代谢学
·
细胞生物学
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分子生物学
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肥胖研究
✓ 已验证
产品关联
DOI
PubMed
高影响因子
危险品化学品经营许可证（带存储）