JOURNAL OF AOAC INTERNATIONAL
·
2019
·Vol. 96
·期 3
·625-629
·
IF 1.201
Wang Mei L,Zhang Jing,Ding Ni N,Zhu Xiao L,Chen Zhi D
A sensitive and simple electrochemical method was developed for successful determination of amaranth in food samples by square-wave adsorptive stripping voltammetry based on an expanded graphite paste electrode (EGPE). The EGPE has strong and sensitive voltammetric responses to amaranth, owing to the multiporous structure and large surface area of EG. The electroanalytical determination of this azo dye was found to be optimal in Britton-Robinson buffer solutions (pH 7.0) under the following experimental conditions: accumulation time, 400 s; accumulation potential, 0.4 V; pulse amplitude, 25 mV; and frequency, 10 Hz. Under the optimum experimental conditions, the oxidation peak current was proportional to the concentration of amaranth over two ranges from 0.01 to 0.1 and 0.1 to 4.0 μM. These linear ranges of the EGPE toward amaranth were wider than other electrodes reported before. The LOD was estimated to be 0.005 μM (S/N = 3:1). The developed method was applied to the determination of amaranth in retsina samples, and the results were confirmed by HPLC. Statistical analysis of these data showed that the results of the two methods compared favorably. This work provides a simple and easy approach to the determination of amaranth in foods with high sensitivity and excellent selectivity.
研究领域:
分析化学
·
食品科学
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DOI
高影响因子
JOURNAL OF AOAC INTERNATIONAL
·
2019
·Vol. 97
·期 1
·121-127
·
IF 1.201
Wang Lili,Deng Jian,Ji Xuezhen,Liu Wanbin,Liang Jun,Yan Xiaona,Chen Dan,Xie Jie
A novel derivative β-cyclodextrin (β-CD) bonded silica gel (β-CD/SiO2) was prepared via carbodiimide activation and used as a chiral stationary phase (CSP). The β-CD/SiO2 CSP was characterizedby X-ray photoelectron spectroscopy and FTIR spectroscopy to prove the successful immobilization of β-CD onto the surface of the silica gel.The thermal behavior of the CSP was studied by differential scanning calorimetry and then used forthe chiral separation of racemic naproxen using HPLC. Several factors affecting the separation efficiency of naproxen enantiomers were investigatedsystematically. The following parameters were selected: methanol–0.01 M phosphate buffer solution (85 + 15, v/v, pH 3.5) was the mobile phase, the flow rate was 1.0 mL/min, and the column temperature was 35°C. Under optimal conditions, the racemic naproxen was efficiently separated with a resolution factor (RS) of 1.70 and a separation factor (α) of 1.25. This method was successfully used for the enantiomeric separation and purity assessment of naproxen in commercial naproxen sustained release tablets.
研究领域:
分析化学
·
药学
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DOI
PubMed
高影响因子
PETROLEUM CHEMISTRY
·
2021
·Vol. 61
·期 11
·1305-1318
·
IF 1.029
Zhu Wenxi,Zheng Xiuhua
Abstract Colloidal Gas Aphron (CGA) drilling fluid is one of the most promising
techniques in underbalanced drilling with excellent plugging and reservoir
protection functions. Due to the limitation of poor thermal stability of
commercial foaming agents used in oilfields, the research on high-temperature
resistant CGA drilling fluid is still a challenge. In this study, a
biodegradable glycine foaming agent AGS-12 was synthesized via a one-step
method. The surface activity, foaming performance (25–150°C) of AGS-12 and the
high temperature performance of AGS-12 based CGA drilling fluid (120–150°C) were
studied. All the results provide a basis for the potential application of AGS-12
as an eco-friendly foaming agent in high-temperature CGA drilling fluids: 1) The
product AGS-12 with 87% conversion rate was synthesized successfully by one-step
method, which can be verified by FT-IR. TGA analysis suggested that AGS-12 had
good thermal stability within 315°C. Moreover, AGS-12 is easily biodegradable
and fully meets the first level discharge standard of petrochemical industry
pollutants. 2) AGS-12 can reduce the surface tension of solvent water from 72.38
to 28.44 mN/m. Analysis of fundamental surface activity parameters illustrates
the higher surface activity of AGS-12, compared with a variety of amino acid
surfactants. 3) Waring-Blender test showed that foams generated by 3% AGS-12
always have higher half-life, foam quality and lower drainage speed than the
foaming agents available on market within 150°C. 4) At 120/140/150°C, aphrons
with diameter of 10–150 µm have been successfully generated in CGA drilling
fluid by using AGS-12 as foaming agent. Rheological and filtration tests
suggested that AGS-12 based CGA drilling fluid is a high-performance drilling
fluid with strong shear thinning behavior, high viscosity, and low filtration
invasion.
研究领域:
石油工程
·
环境科学
·
材料化学
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DOI
高影响因子
JOURNAL OF POLYMERS AND THE ENVIRONMENT
·
2023
·Vol. 31
·期 11
·4770-4783
·
IF 5.3
Wang Guoqiang,Wang Jianyu
In this work, the melt polycondensation method was used to synthesize aliphatic polyesters from 1,12-dodecanediol and aliphatic diacids with even carbon atoms. Gel permeation chromatography, hydrogen-1 nuclear magnetic resonance ( 1 H NMR), infrared spectroscopy, differential scanning calorimetry, wide-angle X-ray diffraction, thermogravimetric analysis, tensile test, dynamic mechanical analysis, and rotational rheometer were used for characterization. All polyesters had high weight average molecular weight (> 60,000 g/mol). Poly(1,12-dodecylene adipate) had the lowest weight average molecular weight (66,360 g/mol) and poor thermal stability. Four polyesters had very flexible molecular chains and shared a crystalline structure with polyethylene. Poly(1,12-dodecylene octanedioate) and poly(1,12-dodecylene sebacate) had tensile strength of 20.8 MPa and 25.3 MPa, respectively, and elongation at break of 255% and 254%, respectively, meaning that their tensile properties were similar to those of polyethylene.
研究领域:
材料科学
·
高分子化学
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DOI
高影响因子
INTERNATIONAL JOURNAL OF HYDROGEN ENERGY
·
2022
·
IF 7.139
Shaojie Shi,Yifei Wang,Biaolong Wang,Fan Wu,Yange Suo,Zhiguo Zhang,Yousheng Xu
Rational design of efficient, cost-effective electrocatalyst towards oxygen reduction reaction (ORR) is of vital importance to the wide application of polymer electrolyte membrane fuel cells. In this work, a novel and simple Na 2 SO 4 -assisted pyrolysis strategy with ZIF-12 as the precursor is reported for the synthesis of cobalt, sulfur, nitrogen, co-doped carbon (termed as CoSNC- x Na 2 SO 4 -T) materials towards ORR. Different from CoNC-800 derived from pure ZIF-12, with the presence of Na 2 SO 4 , the derived CoSNC-0.5Na 2 SO 4 -800 material exhibits layered flake morphology with hierarchical meso-microporous structure. Besides, CoSNC-0.5Na 2 SO 4 -800 material shows higher content of pyridinic-N and graphitic-N, higher relative intensity of Co-N x , higher content of carbon defect, as well as larger specific surface area in comparison with CoNC-800, which results in higher activity of CoSNC-0.5Na 2 SO 4 -800. The CoSNC-0.5Na 2 SO 4 -800 material displays a half-wave potential of 0.88 V, which is superior to that of commercial Pt/C (half-wave potential being 0.86 V). Moreover, CoSNC-0.5Na 2 SO 4 -800 demonstrates a better durability compared with Pt/C. The pyrolysis temperature and the amount of Na 2 SO 4 are found to affect the physiochemical properties and electrochemical performance of the CoSNC- x Na 2 SO 4 -T materials. This work not only provides a facile and novel synthesis approach for the preparation of highly active Co, S, N co-doped carbon materials for ORR, but also disclosing the key structure properties for enhancing the performance of these catalysts.
研究领域:
材料科学
·
能源化学
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DOI
高影响因子
MATERIALS & DESIGN
·
2022
·
IF 9.417
Lingling Pan,Dawei Jiang,Luqi Pan,Zhizhen Meng,Yangyang Zhuang,Yueyue Huang,Fanrong Ye,Changcan Shi,Jie Chen,Jingye Pan
Sepsis is defined as life-threatening organ dysfunction caused by a dysregulated host response to infection and causes high ratios of morbidity and mortality worldwide. Although many potential therapeutic targets have been reported, the therapeutic effect needs to be further improved. Herein, we report a strategy to specifically target inflammation site via anti-ICAM-1 antibody bonded antibacterial peptides polymeric nanoparticle. Antibacterial peptide (KR-12) grafted amphipathic PCL- b -P(OEGMA- co -AMA)- g -Cys-KR-12 block copolymer and PCL- b -P(OEGMA- co -AMA)- g -biotin block copolymer were synthesized by ring-opening polymerization and click chemistry. Then, antibacterial peptides polymeric nanoparticles (AMPNP) were prepared by co-assembly of amphipathic PCL- b -P(OEGMA- co -AMA)- g -Cys-KR-12 and PCL- b -P(OEGMA- co -AMA)- g -biotin in aqueous solution. Intercellular adhesion molecule-1 (ICAM-1) is highly expressed on the surface of inflammatory endothelial cells, and the anti-ICAM-1 antibody can specifically bind to it. To obtain the anti-ICAM-1-AMPNP nanoparticles, biotinylated anti-ICAM-1 antibodies were bonded on the surface of AMPNP nanoparticles through the biotin-avidin system. The anti-ICAM-1-AMPNP nanoparticles had low systemic toxicity and exhibited ideal antibacterial property against drug-resistant bacteria, Gram-negative bacteria and Gram-positive bacteria. The anti-ICAM-1-AMPNP nanoparticles exhibited favorable targeting capabilities to inflammation endothelial cells in vitro and significantly reduced the inflammatory response of CLP mice in vivo . The present investigation might provide a specific strategy for targeting combating sepsis with anti-ICAM-1-AMPNP nanoparticles.
研究领域:
药学
·
纳米技术
·
感染病学
·
免疫学
·
高分子化学
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DOI
高影响因子
MOLECULES
·
2017
·Vol. 22
·期 7
·1122
·
IF 2.861
Dengke Bao,Jingkai Wang,Xiaobin Pang,Hongliang Liu
Oxidative stress has been implicated in the pathogenesis of many kinds of neurodegenerative disorders, particularly Parkinson’s disease. Quercetin is a bioflavonoid found ubiquitously in fruits and vegetables, and has antioxidative activity. However, the underlying mechanism of the antioxidative effect of quercetin in neurodegenerative diseases has not been well explored. Here, we investigated the antioxidative effect and underlying molecular mechanisms of quercetin on PC-12 cells. We found that PC-12 cells pretreated with quercetin exhibited an increased cell viability and reduced lactate dehydrogenase (LDH) release when exposed to hydrogen peroxide (H2O2). The significantly-alleviated intracellular reactive oxygen species (ROS), malondialdehyde (MDA), and lipoperoxidation of the cell membrane of PC-12 cells induced by H2O2were observed in the quercetin pretreated group. Furthermore, quercetin pretreatment markedly reduced the apoptosis of PC-12 cells and hippocampal neurons. The inductions of antioxidant enzyme catalase (CAT), superoxide dismutase (SOD), and glutathione peroxidase (GSH-Px) in PC-12 cells exposed to H2O2were significantly reduced by preatment with quercetin. In addition, quercetin pretreatment significantly increased Bcl-2 expression, and reduced Bax, cleaved caspase-3 and p53 expressions. In conclusion, this study demonstrated that quercetin exhibited a protective effect against oxidative stress-induced apoptosis in PC-12 cells. Our findings suggested that quercetin may be developed as a novel therapeutic agent for neurodegenerative diseases induced by oxidative stress.Keywords:quercetin;antioxidant;oxidative stress;Parkinson’s disease
研究领域:
神经科学
·
药理学
·
分子生物学
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DOI
PubMed
高影响因子
INDUSTRIAL & ENGINEERING CHEMISTRY RESEARCH
·
2026
·
IF 3.9
Zhangxinyu Fan,Yiheng Cui,Weixiang Wang,Yi Sun,Liqian Lin,Xinxin Geng,Guo Tian,Qin Zhong,Boyang Liu
Abstract Global warming has spurred interest in CO2 utilization. Coupling reverse water–gas shift (RWGS) with hydroformylation allows olefins to react with H2/CO2 to produce valuable aldehydes, which is a profitable reaction and helps with carbon fixation. However, temperature mismatch between the two reactions and limited mechanistic understanding hinder the rational design of catalysts. Using density functional theory (DFT) calculations and experimental evaluations, we investigated the effects of different phosphine ligands and acid additives on the performance of silane-free CO2 hydroformylation. Formic acid alters the CO2 activation pathway and reduces the energy barrier, thereby improving catalytic activity and chemoselectivity. The effects of reaction conditions reveal a competitive relationship between CO2 reduction and olefin carbonylation, suggesting that balancing RWGS and hydroformylation rates enhances catalytic performance. Our work not only deepens the mechanism understanding of silane-free CO2 hydroformylation but also paves the way for the rational design of subsequent high-performance catalysts.
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高影响因子
Russian Journal of Physical Chemistry A
·
2026
·Vol. 100
·期 7
·1348-1359
·
IF 0.7
Ren Chaobin,Yaofei Huang,He Zhu,Zhuo Chen,Junlei Shi,Chengxin Shen,Shun Yan,Jingya Peng,Huanxin Li
The solubility properties of coumarin-3-carboxylic acid (CCA) was studied in 12 kinds of alcohol and ester solvents at p = 100 kPa with the temperature range from 278.15 to 318.15 K. It was found that the solubility of CCA increases with the temperature raises. Among the selected solvents, methyl acetate showed the best dissolving ability for CCA, while 2-propanol showed the worst dissolving ability. The obtained data are neatly correlated with four models, including van’t Hoff, λ h , Wilson, and NRTL models, with λ h equation yielding the most accurate predicted results. The dissolving mechanism of CCA was investigated with intermolecular interaction between CCA and solvents by using the COSMO-RS model, and the results indicating that the dissolving process is affected by the intermolecular interaction, molecular polarity, and size of both solvents and CCA. The dissolution thermodynamics analysis shows that the dissolving process of CCA in the twelve solvents is spontaneous, endothermic, and enthalpy driven.
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高影响因子
ACS Nano
·
2019
·
IF 13.903
Yue-Xing Zhang,Jin Fang,Wei Li,Yang Shen,Jing-De Chen,Yanqing Li,Hongwei Gu,Sara Pelivani,Maojie Zhang,Yongfang Li,Jian-Xin Tang
Flexible organic solar cells (OSCs) are considered one key component in wearable, intelligent electronics due to the unique capacity for highly flexible renewable energy sources. However, it is urgently required to enhance their efficiency, as it is far inferior to that of their conventional, glass-based counterparts. To boost the performance of flexible OSCs on plastic substrates, we here present a synergetic transparent electrode structure, which combines electrically conductive silver nanowires, a sol–gel-derived ZnO planarization layer, and imprinted light-trapping nanostructures. This synergetic composite electrode exhibits good properties in terms of optical transparency, electrical conductivity, mechanical flexibility, and low-temperature processability. As a result, the single-junction non-fullerene-based flexible OSCs achieve a power conversion efficiency exceeding 12% due to the synergetic interplay between broadband light trapping and suppressed charge recombination loss. Moreover, these flexible OSCs are repeatedly bendable in both inward and outward bending directions, retaining over 60% of the initial efficiency after 1000 cycles of the bending test at a 3.0 mm radius. These results convey a clear depiction of the practicality of flexible OSCs in a variety of high-performance flexible applications.
研究领域:
光伏技术
·
材料科学
·
柔性电子学
·
纳米技术
·
有机半导体
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DOI
高影响因子
Emerging Contaminants
·
2026
·
IF 6.9
Yao Li,Yao Li,Limei Chen,Xinliang Ding,Pengfei Zhu,Yukang Wu,Weijie Zhou
Perfluoroalkyl and polyfluoroalkyl substances (PFAS) are persistent, bioaccumulative, and toxic environmental contaminants of global concern. Thus, accurate and sensitive detection methods are urgently required to assess human exposure to emerging PFAS. In this study, we developed and validated a highly sensitive LC–MS/MS method for the simultaneous quantification of 19 PFAS in serum, including nine legacy compounds, six short-chain alternatives, and four emerging substitutes, using solid-phase extraction (SPE) for matrix clean-up. The method showed satisfactory recoveries (62.9–131%) and precision (relative standard deviation: 0.347–17.0%) rates, with lower detection limits than previously reported assays. Application to serum samples from 258 children (6–12 years old) from Wuxi revealed widespread PFAS exposure, characterized by high detection frequencies and increased concentrations. Fifteen PFAS were detected in over 80% of samples, including seven legacy compounds, six short-chain alternatives, and two emerging substitutes, with 6:2 chlorinated polyfluorinated ether sulfonate (6:2 Cl-PFESA)—a China-specific perfluorooctanoic acid (PFOS) alternative—reaching 5.16 ng·mL -1 . The multiple linear regression model revealed inverse associations between serum PFAS concentrations and age, BMI, and maternal educational level. Higher fish and vegetable intakes may be associated with increased serum concentrations of several PFAS, including perfluorononanoic acid, perfluorodecanoic acid, perfluoroundecanoic acid, perfluorododecanoic acid, perfluorotridecanoic acid, PFOS, and 6:2 Cl-PFESA, indicating that diet could contribute to children’s internal PFAS burden. These findings demonstrate the utility of the optimized analytical method for comprehensive exposure assessment and provide insights into the potential sources of PFAS exposure in school-aged children, particularly from dietary sources.
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高影响因子
MOLECULAR NEUROBIOLOGY
·
2025
·Vol. 63
·期 1
·215
·
IF 4.3
Wanyi Fang,Shanshan Liu,Yifei Wu,Ting Chen,Xiaohe Lu,Hui Chen
Diabetic retinopathy (DR) is a common neurovascular complication of diabetes and a leading cause of vision loss in the advanced stages. Identifying therapeutic targets to prevent early progression of DR is critical for preserving visual function. Interleukin-12 (IL-12) has emerged as a potential therapeutic agent for early-stage diabetic retinal neurodegeneration. In this study, diabetic mouse models were established, followed by intravitreal injection of IL-12 to evaluate its effects using hematoxylin and eosin staining and RNA sequencing. IL-12 treatment partially prevented the thinning of the nerve fiber layer, ganglion cell layer, and total retina. Bioinformatics analysis of RNA sequencing data revealed enrichment of microglial signatures and enhanced phagocytic function. Western blotting analysis showed that IL-12 promoted the phosphorylation of signal transducer and activator of transcription 4 (STAT4) in microglia. Bioinformatics and quantitative reverse transcription polymerase chain reaction analyses demonstrated that STAT4 activation upregulated the transcription of phagocytosis-related genes, including triggering receptor expressed on myeloid cells 2 (TREM2) and DNAX-activating protein of 12 kDa (DAP12). In vitro and in vivo experiments confirmed that IL-12 upregulates the TREM2/DAP12 signaling pathway on the microglial membrane, enhancing microglial proliferation and phagocytic activity under high-glucose conditions. These findings indicated that IL-12 mitigates early neural injury in DR by promoting microglial phagocytosis through the upregulation of TREM2/DAP12.
研究领域:
眼科学
·
神经科学
·
免疫学
·
分子生物学
·
糖尿病研究
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产品关联
DOI
PubMed
高影响因子
危险品化学品经营许可证（带存储）