JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY
·
2020
·
IF 4.192
Zhi-Ming Cui,Bo-Hang Zhou,Chao Fu,Liu Chen,Juan Fu,Fang-Jun Cao,Xin-Juan Yang,Le Zhou
Inspired by sanguinarine and chelerythrine, a novel antifungal 2-phenylphthalazin-2-ium scaffold as a simple analogue was designed. Most of the 30 compounds showed excellent inhibition activity against almost all eight phytopathogenic fungi, far superior to sanguinarine and chelerythrine. A third of the compounds were more active than azoxystrobin in most cases. Compounds 26 and 27 showed the highest total activity against all the fungi with EC50 means of ca. 4.6 μg/mL. Fusarium solani showed the highest susceptibility with an EC50 mean of 3.62 μg/mL to 19 compounds. A concentration of 25.0 μg/mL 27 can fully control the Colletotrichum gloeosporioides infection in apples over 9 days. Electron microscopic observations showed that 27 was able to damage the structures of the hypha and cell membrane. The structure–activity relationship showed that the presence of electron-withdrawing groups on the C-ring increases the activity against most of the fungi. Thus, 2-phenylphthalazin-2-ium compounds represent promising leads for the development of novel fungicides.
研究领域:
药理学
·
植物保护学
·
有机化学
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产品关联
DOI
PubMed
高影响因子
PHYSICAL CHEMISTRY CHEMICAL PHYSICS
·
2022
·Vol. 24
·期 20
·12550-12562
·
IF 3.945
Xue Fu,Xiaochen Tang,Tingting Chen,Yingjie Xu,Xiang Luo,Yueqing Lu,Xuming Wang,Dandan Qin,Lin Zhang
The interactions between azole-anion-based ionic liquids (AILs) and 2-methyl-3-butyn-2-ol (MBY) play an important role in AIL-promoted carboxylative cyclization of MBY with CO2. To better understand the interactions between AILs ([P66614][Im], [P66614][4-MeIm], and [P66614][4-BrIm]) and MBY, a detailed investigation from the experimental perspective has been carried out in this study. The results show that the derivative of viscosity (η) with the mole fraction of AIL (xAIL) of AIL + MBY mixtures appears to have the maximum value when xAIL ≈ 0.3, while 1H NMR chemical shifts of P-CH2 of [P66614]+ reach the minimum value at xAIL ≈ 0.3, indicating that [P66614]+ of AILs tend to self-aggregate. The interaction parameters (gji–gii) of the systems obtained from η by the Eyring-UNIQUAC equation are positive, and the difference between the bulk and local composition (xi–xii) is always negative, indicating that AILs can interact with MBY. Moreover, excess molar volumes and isentropic compressibility deviations are all negative deviations and become more negative as the temperature increases, reaching a minimum value at xAIL ≈ 0.30, indicating that azole-based anions can form H-bonds with MBY, and MBY molecules tend to enter the aggregates formed by AILs. Consequently, the cage effect is proposed to describe the interactions between AILs and MBY: MBY first enters the cage formed by the aggregation of [P66614]+, and then forms H-bonds with azole-based anions. Finally, the sizes of the particles of the [P66614][Im] + MBY mixture from dynamic light scattering increase first and then decrease with xAIL, with the maximum of 122 nm at xAIL ≈ 0.25, which confirms the rationality of the cage effect.
研究领域:
化学
·
材料科学
✓ 已验证
产品关联
DOI
PubMed
高影响因子
ANALYTICAL CHEMISTRY
·
2018
·
IF 6.042
Mengzhe Guo,Liyan Zhang,Yan Du,Wencheng Du,Dantong Liu,Cheng Guo,Yuanjiang Pan,Daoquan Tang
5-(Hydroxymethyl)-2′-deoxycytidine (5-hmdC), 5-(formyl)-2′-deoxycytidine (5-fodC), and 5-(carboxyl)-2′-deoxycytidine (5-cadC) are crucial intermediate products of the DNA demethylation pathway, which can also act as potential biomarkers reflecting the diagnosis and prognosis in multiple tumors. Detecting 5-hmdC, 5-fodC, and 5-cadC in human urine has various advantages including readily available samples and being noninvasive to patients. However, few works have reported the detection of 5-fodC and 5-cadC due to their trace amounts. Here we developed a novel magnetic hyper-cross-linked microporous polymer (HMP) material based on polyionic liquid (PIL) for the enrichment of 5-hmdC, 5-fodC, and 5-cadC. These magnetic PIL-HMP materials provided specific enrichment superiority for three modified cytidines. After enrichment, the signal intensity of 5-hmdC, 5-fodC, and 5-cadC increased 10–75-fold with lower limits of quantitation (LLOQ) of 0.049, 0.781, and 0.781 ng/mL, respectively. The recoveries were approximately 86.5–95.2% for 5-hmdC, 95.2–107.8% for 5-fodC, and 99.4–102.4% for 5-cadC under the relative standard deviation (RSD) of 0.2–10.3%. Finally, we successfully applied magnetic PIL-HMP materials coupled with high-performance liquid chromatography–electrospray ionization tandem mass spectrometry (HPLC-ESI-MS/MS) in enrichment and quantitative determination of 5-hmdC, 5-fodC, and 5-cadC in human urine of 10 breast cancer patients and 10 healthy people. We found that the level of 5-hmdC decreased in breast cancer patients (p < 0.05), while the levels of 5-fodC and 5-cadC increased (p < 0.05, p < 0.01). Our results demonstrated that the levels of metabolic 5-hmdC, 5-fodC, and 5-cadC in human urine are closely related to breast cancer, which could contribute to the clinical diagnosis and investigation of breast cancer and its occurrence and development mechanisms.
研究领域:
医学
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分析化学
·
肿瘤学
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产品关联
DOI
PubMed
高影响因子
Environmental Chemistry Letters
·
2011
·Vol. 9
·期 4
·535-537
·
IF 2.051
Wang Junhua,Zhang Xiqin,Zhou Yun
This is the first case applying 2-haloethylamine to CO 2 capture. The prospect of global warming and the urgent need to reduce atmospheric concentration of carbon dioxide has prompted actions at many levels. The conventional capture of carbon dioxide is predominantly based on chemical absorption using ethanolamine. Recent developments of carbon dioxide capture focus on new materials, such as ionic liquids, zeolites, membranes, carbonaceous absorbents, and metal–organic frameworks. However, no unique solution exists currently to solve the problem of carbon dioxide capture. In order to examine the efficiency of 2-chloroethylamine as an absorbent of CO 2 , we treated an aqueous solution of 2-chloroethylamine hydrochloride with CO 2 in the presence of an alkali, e.g., NaOH, under ambient conditions. The absorption was complete within 30 min, seemingly following first-order reaction kinetics. Furthermore, we succeeded in capturing CO 2 from ambient air using 2-chloroethanolamine. The efficiency of 2-chloroethylamine as an absorbent of CO 2 could be attributed to the production of stable 2-oxazolidinone, therefore, this reaction is favored thermodynamically. Compared with previously reported absorbents, this novel system is capable of capturing CO 2 with an extremely high efficiency of 1 mol per mol absorbent under ambient conditions, even from the atmosphere. This potential method could be used to capture CO 2 particularly from small, mobile, or low-concentration emission sources.
研究领域:
化学工程
·
环境科学
✓ 已验证
DOI
高影响因子
JOURNAL OF CHEMICAL AND ENGINEERING DATA
·
2016
·
IF 1.835
Ying Zhang,Xiong Zheng,Maogang He,Yutian Chen
Ethers are usually used as gasoline additives, and now 2-methoxy-2-methylpropane (MTBE) is the most widely used fuel additive. The speed of sound in MTBE with a specified mass purity higher than 0.990 (GC) was measured by the Brillouin light scattering method in the temperature range of 293.15–673.15 K and for pressures up to 10 MPa, including saturated liquid/vapor, liquid, and supercritical fluid. The correlations for the speed of sound in saturated liquid/vapor and liquid were proposed by employing the experimental results. Comparing the calculated results with the experimental data, the average absolute deviations are 0.50% for saturated liquid, 0.20% for saturated vapor, and 0.24% for liquid. The tendency of speed of sound to temperature and pressure was also analyzed.
研究领域:
物理化学
·
燃料科学
✓ 已验证
产品关联
DOI
高影响因子
CORROSION
·
2013
·Vol. 69
·期 7
·672-680
·
IF 1.772
Jiang Y.Y.,Chen Y.,Ye Z.Y.,Chen H.,Zhang Z.,Zhang J.Q.,Cao C.N.
N-[2-[(2-aminoethyl) amino] ethyl]-9-octadecenamide (AAOA) has been synthesized in the lab, then tested as an effective and economic acid inhibitor for A3 steel in an acid medium with electrochemical techniques (electrochemical impedance and polarization curve). The results show that AAOA acts as a good mixed-type inhibitor for A3 steel in 1 M hydrochloric acid (HCl) solution, and the inhibition efficiency reaches 94% at the concentration of 200 mg/L. The corrosion current density of A3 steel increases with the increasing temperature from 20°C to 60°C. Meanwhile, Langmuir isotherm is found to provide the description of the adsorption behavior of AAOA, and the value of adsorption free energy (ΔG 0 ) is as low as low as −37.3 kJ/mol. One can assume the adsorption of inhibitor molecules on the metal surface is by chemisorption, which has been understood taking into account some other adsorption parameters (ΔH 0 , ΔS 0 ) and the activation parameters (E a , ΔH * , ΔG * ).
研究领域:
材料科学
·
腐蚀与防护
·
电化学
✓ 已验证
DOI
高影响因子
NANOTECHNOLOGY
·
2020
·Vol. 31
·期 32
·325502
·
IF 3.551
Nianfeng Shi,Shupei Sun,Bo Zhang,Qian Du,Yanxin Liao,Xiaoming Liao,Guangfu Yin,Zhongbing Huang,Ximing Pu,Xianchun Chen
Co(OH)2 nanosheets/Cu(OH)2 nanorods composite electrodes for non-enzymatic glucose detection were fabricated by electrodepositing Co(OH)2 nanosheets on Cu(OH)2 nanorods substrate grown directly on the copper sheet via a simple one-step reaction. The Co(OH)2 nanosheets/Cu(OH)2 nanorods composite electrode was characterized by scanning electron microscopy, energy dispersive x-ray spectroscopy, x-ray diffraction and x-ray photoelectron spectroscopy. The glucose sensing performance of the composite electrode was investigated by cyclic voltammetry and chronoamperometry. The composite electrode shows high sensitivity of 2366 µA mM−1 cm−2 up to 2 mM with a lower detection limit of 0.17 mM (S/N = 3). The composite electrode is highly selective to glucose in the presence of various substances that always co-exist with glucose in real blood samples. The response of the composite towards human blood serum was in good agreement with that of commercially available glucose sensors, suggesting that a promising electrode material for highly sensitive and selective non enzymatic detection of glucose can be envisioned.
研究领域:
电化学
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纳米材料
·
生物传感器
·
分析化学
✓ 已验证
产品关联
DOI
PubMed
高影响因子
BRAZILIAN JOURNAL OF CHEMICAL ENGINEERING
·
2020
·Vol. 37
·期 1
·297-305
·
IF 1.027
Yu Shuai,Hao Cui,Liu Yuzhi,Chen Hui,Cheng Yan,Xue Fumin
The solubility of 2-acrylamido-2-methyl-1-propane sulfonic acid (AMPS) in seven pure solvents, methanol, ethanol, 2-propanol, 1-butanol, isopentanol, acetone, and ethyl acetate, in the temperature range between 283.15 and 328.15 K at atmospheric pressure (101.3 kPa) is reported in this paper. The solubility of 2-acrylamido-2-methyl-1-propane-sulfonic acid increases with temperature in all selected solvents. The van’t Hoff equation, modified Apelblat equation, Wilson model, and λh model were applied to correct the solubility data. The results show that the modified Apelblat equation fits the best, with an average relative deviation of less than 3.70%. The mixing properties, such as Gibbs free energy, enthalpy and entropy of AMPS, were calculated based on the van’t Hoff equation. The dissolution process of AMPS in all solvents selected is endothermic, non-spontaneous and enthalpy-driven.
研究领域:
化学
·
物理化学
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产品关联
DOI
高影响因子
COLLOIDS AND SURFACES A-PHYSICOCHEMICAL AND ENGINEERING ASPECTS
·
2020
·
IF 3.99
Yu Zhang,Xiaohua Li,Xinyu Ma,Shaoling Bai,Jianhua Zhang,Ruiwei Guo
Copolymers of acrylamide (AM) and sodium 2-acrylamido-2-methylpropanesulfonate (AMPSNa) with different compositions and molecular weights were prepared by aqueous RAFT polymerization using S , S '-bis(α,α'-dimethyl-α"-acetic acid) trithiocarbonate (BDMAT) as a RAFT agent. The critical phase separation concentrations (C p *) of these copolymers, termed P(AM-AMPSNa)s, in ammonium sulfate ((NH 4 ) 2 SO 4 ) solution were determined by a turbidimetric method. The effects of molecular weight and monomer composition of P(AM-AMPSNa)s, (NH 4 ) 2 SO 4 concentration, and temperature on C p * were studied in detail. Based on these phase separation characters of P(AM-AMPSNa)s, the mechanism of aqueous RAFT dispersion polymerization of AM/AMPSNa in (NH 4 ) 2 SO 4 aqueous solution was discussed.
研究领域:
高分子化学
·
材料科学
✓ 已验证
产品关联
DOI
高影响因子
RSC Advances
·
2018
·Vol. 8
·期 72
·41270-41279
·
IF 2.936
Ruizhang Xu,Jiantao Wang,DanDan Chen,Feng Yang,Jian Kang,Ming Xiang,Lu Li,Xingyue Sheng
Inspired by the special pH value-responsive and strong hydrophilic ability of poly(2-ethyl-2-oxazoline) (PEOX), in this study, asymmetric polysulfone (PSf) and PSf/PEOX ultrafiltration membranes were prepared by a phase separation method, wherein different dosages of PEOX (0–3 wt%) were incorporated into the PSf casting solution as polymeric additives. The effects of PEOX dosages on the phase separation kinetics, chemical properties, morphology, hydrophilicity, porosity and performances such as pure water flux (PWF), Bull Serum Albumin (BSA) rejection, pH value responsiveness and anti-fouling property were investigated in detail. The hydrophilicity, pure water flux, BSA rejection and anti-fouling property were improved significantly after the incorporation of PEOX. The PWF increased from 213.5 L m−2 h−1 to 419.8 L m−2 h−1 as the PEOX dosage increased from 0 to 1 wt%, meanwhile, the BSA rejection increased to more than 98.4%. Viscosity and effective diffusion coefficient of PSf/PEOX solution were studied to elucidate the role of PEOX in phase separation and morphology of the membrane. Results showed that the incorporation of PEOX leads to the phase separation of casting solution by making it more prone to instantaneous demixing, further determining the morphology and performances of the membrane. Interestingly, the resulting membranes showed pH value-responsive properties, whereby the water flux increased along with an increase in the pH value. This interesting feature of the membranes broadens their application potential in many specific cases. The related filtration mechanism has also been proposed.
研究领域:
材料科学
·
环境工程
·
生物医学工程
✓ 已验证
产品关联
DOI
PubMed
高影响因子
APPLIED SURFACE SCIENCE
·
2024
·
IF 6.3
Pan Xiao,Jingjing Xiao,Zhihong Xiao,Rukuan Liu,Zhiyong Zhang,Chuansheng Chen,Changzhu Li
Herein, a novel surfactant dihexyl (2-amino-2-(hydroxyimino)ethyl) phosphonate (DHAHEP) was synthesized by combining phosphonate and amidoxime groups in the same molecule, and used as a flotation collector for quartz vein-type wolframite. The Micro-flotation results showed that DHAHEP has excellent collection performance for wolframite, at pH 2 ∼ 4.5, the flotation recovery of DHAHEP for wolframite was over 90 %, while that for quartz was less than 60 %. The wolframite-quartz artificial mixed ores experiments demonstrated that at pH ∼ 4 and DHAHEP concentration of 8 × 10 -5 mol·L -1 , the flotation recovery of wolframite was 64.5 % and the grade was 48.9 %. Zeta potential and contact angle experiments elucidated that DHAHEP anchored on the wolframite surface mainly in the form of cations, increasing the hydrophobicity of the surface and thus separating the wolframite from quartz by flotation. FTIR, XPS, and DFT calculation further revealed that DHAHEP had an obvious flotation separation effect on quartz vein-type wolframite, it was mainly electrostatically adsorbed on the WO 4 2- sites of the wolframite surface in the form of cations, and also captured wolframite by forming chemical bonds with the Fe active sites through the phosphoryl and amidoxime groups in its molecular structure.
研究领域:
矿物加工工程
·
表面化学
✓ 已验证
产品关联
DOI
高影响因子
CHEMICAL ENGINEERING RESEARCH & DESIGN
·
2018
·
IF 2.795
Mengjie Sun,Meng Li,Pin Wang,Xu Zhang,Cuiming Wu,Yonghui Wu
Anion exchange membranes are prepared by phase inversion of P84 co -polyimide to obtain porous structure, and then chemically modified by branched polyethylenimine. The porous membranes are compared with a dense P84 membrane. The dense membrane is hydrophobic with large area resistance (>85 Ω cm 2 ), while the porous membranes are hydrophilic with low area resistance (2.4–3.5 Ω cm 2 ), lower than that of commercial membrane CJMA-3 (6.0 Ω cm 2 ). The ion exchange capacities are in the range of 0.83–0.86 mmol/g and the water uptake values are 90–130%, both of which are higher than those of dense P84 membrane and CJMA-3 membrane (0.5–0.6 mmol/g; 15–20%). The P84 co -polyimide membranes are utilized in bipolar membrane electrodialysis (BMED) process to produce N -2-hydroxyethylpiperazine- N ′-2-ethanesulfonic acid (HEPES). The porous membranes can decrease the transport resistance of HEPES − ions and yield high recovery ratio and current efficiency, while the dense membrane is unsuitable for BMED . The output of HEPES is increased significantly if the membranes have finger- or tear-like pores, as well as higher ion exchange capacity. The HEPES − recovery ratios are 52.3–61.6% after running 6 h under 40 V, which are higher than that of membrane CJMA-3 (46.5%). The current efficiency can reach up to 86.1% and the energy consumption is only 3.92 kWh/kg by using the optimal porous membrane M-1, which are better than membrane CJMA-3 (65.5%, 5.15 kWh/kg). Hence, the porous membranes have high potential for producing organic acid with high molecular weight.
研究领域:
化学工程
·
材料科学
✓ 已验证
DOI
高影响因子
危险品化学品经营许可证（带存储）