JOURNAL OF MATERIALS SCIENCE
·
2016
·Vol. 51
·期 24
·10849-10862
·
IF 2.302
Zhang Man,Li Chuan,Gao Huiqi,Fu Wei,Li Yingying,Tang Liwei,Zhou Zhiming
Twelve salts of 3-nitro-1,2,4-triazol-5-one (NTO) (ammonium, hydrazinium, guanidinium, aminoguanidinium, diaminoguanidinium, triaminoguanidinium, N -carbamoylguanidinium, semicarbazidium, 1,5-diamino-1,2,4-tetrazolium, 3,4,5- triamino-1,2,4-triazolium, 3,6,7-triamino-7H-[1, 2, 4]triazolo[5,1-c][1,2,4]triazol-2- ium, and 4,4′,5,5′-tetraamino-3,3′-bi-1,2,4-triazolium) were synthesized. The new salts were fully characterized by 1 H and 13 C NMR spectroscopy, infrared spectroscopy, and elemental analysis. The crystal structures of salts 10 and 11 were determined by single-crystal X-ray diffraction. All energetic salts except salt 6 exhibit excellent thermal stabilities with decomposition temperatures ranging from 203 to 270 °C. The densities of salts ranged from 1.65 to 1.88 g cm −1 as measured by a gas pycnometer. Theoretical performance calculations (Gaussian 03 and EXPLO5 v6.01) yielded detonation pressures and detonation velocities for the energetic salts, ranging from 24.4 to 38.1 GPa and 8136 to 9575 m s −1 , respectively. In particular, salt 2 has an outstanding detonation performance ( P
cj = 38.1 GPa, v
D = 9575 m s −1 ) with a satisfactory acidity compared to that of NTO ( pK
a = 5.63 versus pK
a = 2.37). Furthermore, the particles of salt 2 form two-dimensional blades of submicron size, as determined by scanning electron microscopy analysis. Meanwhile, salt 2 was compatible with TNAZ, TATB, TKX-50, Al, NH 4 ClO 4 , CL-20, TNT, and F2603 fluororubber, as determined by differential scanning calorimetry or vacuum stability tests.
研究领域:
化学
·
材料科学
·
爆炸物研究
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产品关联
DOI
高影响因子
Journal of Environmental Chemical Engineering
·
2025
·
IF 7.2
Yu Fu,Fangbo Zhao,Yingzheng Liu,Ruiqi Li,Hongxu Chen,Liu Yang,Zhiguo Li,Mingcong Wu,Dan Wang
In this research, we introduce a novel and efficient approach for enhancing both the antibacterial efficacy and resistance to protein fouling of nanofiltration (NF) membranes, marking the first report of a method capable of concurrently addressing these critical membrane performance parameters. After traditional interface polymerization (IP), NF membranes were post-treated by the antibacterial N-(3-Aminopropyl)-imidazole (ANPI) which can be grafted on the membrane by its amino group reacting with rest acyl chloride in IP on the surface. After parameter optimization of the ANPI concentration, the modified membrane NF-12 demonstrated up to 99% antibacterial activity against two representative pathogens, Escherichia coli and Staphylococcus aureus . Except for this, due to the zwitterionic effect, the modified membrane achieved a remarkable 68.7% enhancement in water flux and the recovery rate of BSA cyclic pollution reached 97.5%. From mechanism analysis, it can be proposed that the post-grafted ANPI brought antibacterial properties to the NF membrane, which was able to kill bacteria attached to the membrane surfaces. Also, the imidazole protonation introduced positive charges to the NF membrane surface, mixing with negative charges produced by acyl chloride hydration, which produced the zwitterionic effect and facilitated the formation of a robust hydrophilic hydration layer, thereby significantly diminishing the adhesion of contaminants.
研究领域:
材料科学
·
环境工程
·
生物医学
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产品关联
DOI
高影响因子
iScience
·
2024
·
IF 4.6
Ruobing Wang,Dan Su,Yueze Liu,Hua Huang,Jiangdong Qiu,Zhe Cao,Gang Yang,Hao Chen,Wenhao Luo,Jinxin Tao,Guihu Weng,Taiping Zhang
Summary Nuclear factor kappa B (NF-κB) plays a pivotal role in the development of pancreatic cancer, and its phosphorylation has previously been linked to the regulation of NUAK2. However, the regulatory connection between NF-κB and NUAK2, as well as NUAK2’s role in pancreatic cancer, remains unclear. In this study, we observed that inhibiting NUAK2 impeded the proliferation, migration, and invasion of pancreatic cancer cells while triggering apoptosis. NUAK2 overexpression partially resisted apoptosis and reversed the inhibitory effects of the NF-κB inhibitor. NF-κB transcriptionally regulated NUAK2 transcription by binding to the promoter region of NUAK2. Mechanistically, NUAK2 knockdown remarkably reduced the expression levels of p -SMAD2/3 and SMAD2/3, resulting in decreased nuclear translocation of SMAD4. In SMAD4-negative cells, NUAK2 knockdown impacted FAK signaling by downregulating SMAD2/3. Moreover, NUAK2 knockdown heightened the sensitivity of pancreatic cancer cells to gemcitabine, suggesting that NUAK2 inhibitors could be a promising strategy for pancreatic cancer treatment.
研究领域:
肿瘤学
·
分子生物学
·
细胞生物学
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产品关联
DOI
PubMed
高影响因子
RSC Advances
·
2021
·Vol. 11
·期 50
·31601-31607
·
IF 3.361
Bi-Xian Zhang,Pei-Shan Li,Ying-Ying Wang,Jia-Jun Wang,Xiu-Lin Liu,Xue-Yang Wang,Xiao-Mei Hu
Indole-3-acetic acid (IAA) plays an important role in the growth and development of plants. In this study, a series of predominant strains were isolated and identified as Enterobacter sp. with remarkable IAA-producing capabilities. The IAA-producing strains are mainly tryptophan-dependent and have significantly high yields of IAA (3477 μg mL−1 and 3378 μg mL−1). The ipdC gene encoding indole-3-pyruvate decarboxylase was identified by genomic analysis and RT-qPCR analysis, indicating the involvement of the indole-3-pyruvic acid (IPyA) pathway of IAA biosynthesis. The IPyA pathway was also confirmed by the intermediate assay. The IAA product of microbial metabolites was isolated, purified and characterized. These microbes exhibiting IAA production significantly promoted the growth of maize, increasing root length, plant height, fresh weight and dry weight. Thus, Enterobacter sp. with high IAA production has great prospects in agricultural and industrial applications.
研究领域:
微生物学
·
植物学
·
农业科学
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DOI
PubMed
高影响因子
ACS Omega
·
2025
·
IF 4.3
Zhenghu Min,Xingdan Wang,Xiaoqiu Yang,Qiwei Zhang,Qi Zheng
Glycosylation profiling is an effective methodology for achieving a comprehensive understanding of glycoproteins and their alterations in a multitude of pathological conditions. However, in comparison to N-glycosylation, O-glycosylation presents significant challenges in terms of both qualitative and quantitative mass spectrometric analyses. A recently developed oxidative release protocol enables the selective formation of O-glycans containing a carboxyl group derived from the amino acid residue. In this study, 3-nitrophenylhydrazine was used to derivatize the common carboxyl group in a mild hydrophilic solution. Derivatization resulted in the generation of a series of report ions for serine, threonine, sialic acid, and O-acetylated sialic acid residues, thereby facilitating the identification of O-glycans and their attached amino acid residues, as well as the determination of the number of O-acetyl groups. A total of 65 O-glycans can be identified from bovine mucin. Furthermore, the analytical strategy revealed that O-acetylated N-acetylneuraminic acid (Neu5Ac)-containing O-glycans from horse serum exhibited distinctive fragmentation patterns in comparison to those from bovine mucin. Additionally, the presence of deaminoneuraminic acid (KDN)-containing O-glycans was successfully confirmed in fish intestinal tissue. These findings suggest that this method provides an economical and potentially valuable tool for large-scale O-glycosylation studies in complex biological samples.
研究领域:
生物化学
·
蛋白质组学
·
分析化学
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产品关联
DOI
PubMed
高影响因子
MICROCHIMICA ACTA
·
2024
·Vol. 191
·期 7
·1-11
·
IF 5.3
Zhao Zhihua,Yao Longqi,Zhang Shuaiwen,Shi Qingsheng,Rahmatullah Abu Bakker Md,Wu Lan
Industrialization and agricultural demand have both improved human life and led to environmental contamination. Especially the discharge of a lot of poisonous and harmful gases, including ammonia, ammonia pollution has become a pressing problem. High concentrations of ammonia can pose significant threats to both the environment and human health. Therefore, accurate monitoring and detection of ammonia gas are crucial. To address this challenge, we have developed an ammonia gas sensor using In(OH) 3 /Ti 3 C 2 T x nanocomposites through an in-situ electrostatic self-assembly process. This sensor was thoroughly characterized using advanced techniques like XRD, XPS, BET, and TEM. In our tests, the I/M-2 sensor exhibited remarkable performance, achieving a 16.8% response to 100 ppm NH 3 at room temperature, which is a 3.5-fold improvement over the pure Ti 3 C 2 T x MXene sensor. Moreover, it provides swift response time (20 s), high response to low NH 3 concentrations (≤ 10 ppm), and excellent long-term stability (30 days). These exceptional characteristics indicate the immense potential of our In(OH) 3 /Ti 3 C 2 T x gas sensor in ammonia detection. Graphical Abstract
研究领域:
材料科学
·
环境科学
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产品关联
DOI
PubMed
高影响因子
CERAMICS INTERNATIONAL
·
2024
·
IF 5.1
Shumin Duan,Zhenjun Qing,An Liu,Haiyan Li,Yan Xue
The single-phase, cubic-structured Ba 3 La(PO 4 ) 3 ceramics were synthesized using the traditional solid-state reaction method. The ceramic sintered at 1375 °C exhibited a relative density of 95.4 %, indicative of a dense microstructure and excellent sintering characteristics. Furthermore, they displayed remarkable microwave dielectric properties : ε r = 9.54, Q × f = 32820 GHz, and τ f = −43.1 ppm/°C. In addition, the relative density is positively correlated with ε r and Q × f of ceramics. According to the complex chemical bond theory, the ionicity of the Ba/La–O bond has a more significant impact on the ε r , while the lattice energy and bond energy of the P–O bond respectively dominate the Q × f and τ f values. Moreover, the results from Raman spectroscopy indicate that several prominent Raman bands are associated with the vibration of the P–O bond. These findings suggest that Ba 3 La(PO 4 ) 3 ceramics hold promise for applications in high-frequency microwave communication.
研究领域:
材料科学
·
物理学
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产品关联
DOI
高影响因子
FOOD AND CHEMICAL TOXICOLOGY
·
2014
·
IF 2.61
Chang Li,Shao-Ping Nie,Yong-qiang Zhou,Ming-Yong Xie
3-monochoropropane-1, 2-diol (3-MCPD) esters from edible oils are considered to be a possible risk factor for adverse effects in human. In the present study, the exposure assessment of 3-MCPD esters to Chinese population was performed. A total of 143 edible oil and fat samples collected from Chinese markets were determined for the concentrations of 3-MCPD esters. The concentration data together with the data of fats consumed were analyzed by the point evaluation and probabilistic assessment for the exposure assessment. The point evaluation showed that the mean daily intake (DI) of 3-MCPD esters were lower than the value of provisional maximum tolerable daily intake (PMTDI) of 3-MCPD (2 µg/kg BW/d). The mean DI values in different age groups obtained from probabilistic assessment were similar to the results of the point evaluation. However, in high percentiles (95th, 97.5th, 99th), the DI values in all age groups were undesirably higher than the value of PMTDI. Overall, the children and adolescents exposed more to 3-MCPD esters than the adults. Uncertainty was also analyzed for the exposure assessment. Decreasing the level of 3-MCPD esters in edible oils and consuming less oil were top priority to minimize the risk of 3-MCPD esters.
研究领域:
食品安全
·
毒理学
·
营养学
✓ 已验证
DOI
高影响因子
LWT-FOOD SCIENCE AND TECHNOLOGY
·
2016
·
IF 2.711
Chang Li,Yongqiang Zhou,Jianpeng Zhu,Sunan Wang,Shaoping Nie,Mingyong Xie
3-chloropropane-1, 2-diol (3-MCPD) esters are a kind of food processing contaminants that especially occur in edible oil . This study investigated the impact of various factors on the formation of 3-MCPD esters in edible oil models with sodium chloride as chlorine donator during heat processing . The amount of 3-MCPD esters generated in the models were positively correlated with the concentration of sodium chloride. Fe 3+ could significantly promote the formation of 3-MCPD esters. The formation of 3-MCPD esters also depended on pH value of oil, heating temperature and time. The highest level of 3-MCPD esters were obtained at pH 4.0 (2925.3 μg/kg), at 220 °C (9509.8 μg/kg) and for 8 h (4852.4 μg/kg), respectively. 3-MCPD esters were generated much more in the continuous heating model than in the intermittent one. The results are valuable to better understand the formation of 3-MCPD esters and also can provide references for reduction of 3-MCPD esters during edible oil processing and household cooking.
研究领域:
食品科学
·
毒理学
✓ 已验证
产品关联
DOI
高影响因子
MOLECULES
·
2024
·Vol. 29
·期 22
·5384
·
IF 4.2
He Huang,Yating Zhang,Qiu Du,Changji Zheng,Chenghua Jin,Siqi Li
The escalating threat of antibiotic-resistant bacteria and fungi underscores an urgent need for new antimicrobial agents. This study aimed to synthesize and evaluate the antimicrobial activities of two series of 3-alkylidene-2-indolone derivatives. We synthesized 32 target compounds, among which 25 exhibited moderate to high antibacterial or antifungal activities. Notably, compounds10f,10g, and10hdemonstrated the highest antibacterial activity with a minimum inhibitory concentration (MIC) of 0.5 μg/mL, matching the activity of the positive control gatifloxacin against three Gram-positive bacterial strains:Staphylococcus aureusATCC 6538, 4220, and Methicillin-resistantStaphylococcus aureusATCC 43300. Moreover, the three most active compounds10f,10g, and10hwere evaluated for their in vitro cytotoxicity in the HepG2 cancer cell line and L-02; only compound10hwas found to exert some level of cytotoxicity. These findings suggest that the synthesized 3-alkylidene-2-indolone derivatives hold potential for further development as antibacterial agents.
研究领域:
药物化学
·
微生物学
·
抗感染研究
✓ 已验证
DOI
PubMed
高影响因子
SENSORS AND ACTUATORS B-CHEMICAL
·
2022
·
IF 9.221
Yiqun Zhang,Chong Wang,Fengmin Liu,Xiaoying Sun,Xinhao Guo,Lianjing Zhao,Geyu Lu
In recent years, researchers have discovered that self-assembled monolayer functionalized surfaces could improve the gas-sensing performance of semiconductor oxide-based sensors. In the present work, metal-organic framework material ZIF-8 was selected as the self-sacrificial template, and then ZIF-8 materials were calcined at a high temperature to obtain ZnO nanoparticles . Subsequently, the surface of ZnO was modified to install a single layer of 3-aminopropyltriethoxysilane (APTES). In comparison with the pure ZnO-based sensor, the sensor based on 0.5 vol% APTES/ZnO had higher response to 2-butanone. The response has remarkably improved mainly due to APTES molecules capture electrons from the surface of ZnO to widen the electron depletion layer . In addition, the amine (–NH 2 ) group of the APTES monolayer enhanced the specific interaction between the sensing material and 2-butanone, thereby the performance of the sensor was improved. After functionalization with 0.5 vol% APTES, the lower detection limit of the sensor reached as low as 200 ppb, while that of the pure ZnO-based sensor was 500 ppb.
研究领域:
材料科学
·
化学工程
✓ 已验证
DOI
高影响因子
Crystals
·
2024
·Vol. 14
·期 5
·431
·
IF 2.4
Zhenggang Zou,Jiaolin Weng,Chun Liu,Yiyang Lin,Jiawei Zhu,Yijian Sun,Jianhui Huang,Guoliang Gong,Herui Wen
Inorganic scintillation crystals have been widely used in applications of high-energy physics, nuclear medical imaging, industrial nondestructive inspection, etc. In this work, a single crystal Ba3Y(PO4)3(BYP) with 1.0 at% Ce3+-doping concentration was first grown by the Czochralski method, and the electronic structure was calculated using first principles based on density functional theory. In addition, a series of Ce3+-doped BYP phosphors were synthesized, and the fluorescence emission under UV excitation was measured through low-temperature spectroscopy, containing double-peaked emission from 5d–4f transition and self-trapped exciton recombination. A comparison of the UV and X-ray-excited fluorescence spectra reveals the existence of oxygen vacancies as well as F+ centers in the crystal. The air annealing of the crystal effectively reduces the thermoluminescence defects but reduces the emission intensity under UV or X-ray excitation. The BYP:Ce crystal shows a fast decay lifetime of 15.5 ns, and the fast component is as short as 8 ns. The results show that the Ce3+-doped BYP crystal has potential as a kind of scintillator with fast decay properties.
研究领域:
材料科学
·
光学
✓ 已验证
产品关联
DOI
高影响因子
危险品化学品经营许可证（带存储）